2-Chloro-N,N-dimethylethanamine hydrochloride (第二类监控化学品,不能销售)二甲氨基氯乙烷盐酸

CAS 4584-46-7 MFCD00012516

化学结构图

4584-46-7
SMILES: CN(C)CCCl.Cl

化学属性

Mol. FormulaC₄H₁₁Cl₂N
Mol. Weight144.04
Melting Point203-206°C (dec.)
TSCAYes
SolubilitySoluble in water (2000 mg/ml at 20 °C), and alcohol.
Stability易吸潮

别名和识别编码

Chemical Name2-Chloro-N,N-dimethylethanamine hydrochloride
CAS Number4584-46-7
Alfabeta NameCHLOROETHYLDIMETHYLAMINEHYDROCHLORIDE 2-
MDL NumberMFCD00012516
Synonym (2-Chloroethyl)dimethylamine, h (Β-氯乙基)二甲胺盐酸盐 (β-Chloroethyl)dimethylamine hydrochloride (β-氯乙基)二甲胺,盐酸盐 1-(di 1-CHLORO-2-DIMETHYLAMINOETHANE HYDROCHLORID 1-Chloro-2-(dimethylamino)ethane hydrochloride 1-Chloro-2-N, 1-N,N-dimethylamino-2-chloroethane hydrochloride 1-氯-2-二甲基氨基乙烷 盐酸盐 2-(二甲基氨基)乙基氯 盐酸盐 N-(2-氯乙基)二甲胺 盐酸盐 2- 2-(DIMETHYLAMINO)ETHYL CHLORIDE HCL 2-(Dimethylamino)ethyl chloride hydrochloride 2-(二甲基氨)乙基氯 盐酸盐, 98+% 2-(二甲氨基)乙基氯盐酸盐 2-CHLORO-N,N-DIMETHYLETHYLAMINE HYDROCHLORID 2-Chlor-N,N-dimethyl-1-ethanamin Hydrochlordid 2-Chloro-N,N-dimethylethanamine hydrochlo 2-Chloro-N,N-dimethylethylamine Hydrochloride {} {} {} {} {} {} { {} {} {} {} {} {} {uni_hamburg} 2
PubChem Substance ID11636816
EC Number224-970-1
Beilstein Registry Number3591234
Chemical Name Translation(第二类监控化学品,不能销售)二甲氨基氯乙烷盐酸
Wiswesser Line NotationG2N1&1 &GH
InChIInChI=1S/C4H10ClN.ClH/c1-6(2)4-3-5;/h3-4H2,1-2H3;1H
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分类

  • Alkylation Reagents, Amine Salts, Analytical Reagents, Analytical/Chromatography, Building Blocks, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents GC, General Alkylation Reagents, Nitrogen Compounds, Organic Building Blocks, Reagents for Alkylation & Esterification
  • {uni_hamburg} no charge; 2fragments; ionic
  • {SA} Alkylation Reagents, Amine Salts, Analytical Reagents, Analytical/Chromatography, Building Blocks, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents GC, General Alkylation Reagents, Nitrogen Compounds, Organic Building Blocks,

产品应用

  • 医药中间体。用于生产抗组胺药盐酸派力本沙明。

相关文献及参考

  • Short: III/20a
  • Short: EINECS
  • Beilstein: 4,III,237

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T+;N T T,N,T+
RTECSKQ9020000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P312
  • P301+P316
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P316
  • P318
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P361+P364
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
UN Number UN 2811 6.1/PG 3 2811 UN2811
Risk Statements
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R51/53
  • R26 Very toxic by inhalation 吸入极毒
Storage condition 4°C, Hygroscopic Hygroscopic 易吸潮,密封保存
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 720 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,391,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Gastrointestinal - other changes
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 2,1055,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Blood - hemorrhage
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0539178

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 97,25,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 238 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Sci

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1700 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 95,237,1982

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,81,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 umol/L
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 31,67P,1979

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 5 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,33,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,33,1981

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southf

其他信息

  • 外观性质:有吸湿性。溶于水(20℃,2000g/L)和乙醇。有毒。有刺激性熔点:205-208℃
  • Alfa Aesar:2-二甲基氨乙基氯盐酸盐,98+% 2-Dimethylaminoethyl chloride hydrochloride, 98+%(4584-46-7)
  • MOL 文件:4584-46-7.mol
  • 二甲氨基氯乙烷盐酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 115825000 二甲氨基氯乙烷盐酸 2-Dimethylaminoethyl chloride hydrochloride 99% 500 GR 506元 2010/06/21 115820025 二甲氨基氯乙烷盐酸 2-Dimethylaminoethyl chloride hydrochloride 99% 2.5 KG 1999元 2010/06/21 115821000 二甲氨基氯乙烷盐酸 2-Dimethylaminoethyl chloride hydrochloride 99% 100 GR 173元
  • MSDS 信息:2-chloroethyldimethylammonium chloride(4584-46-7).msds
  • 用途一:用于生产硅油、硅橡胶等
  • Acros Organics:2-(二甲氨基)乙基氯盐酸盐 2-Dimethylaminoethyl chloride hydrochloride, 99%(4584-46-7)
  • 用途三:医药中间体。用于生产抗组胺药盐酸派力本沙明。
  • 方法一:由二甲胺经与氯乙酐缩合、氯化亚砜氯化而得。
  • 上游原料:氧氯化硫 --> N,N-二甲基乙醇胺 --> 氯乙酸酐
  • 海关编码:29211980
  • 用途二:用作有机合成、医药中间体
  • 敏感性:Hygroscopic
  • Sigma Aldrich:4584-46-7(sigmaaldrich)
  • 图谱信息:二甲氨基氯乙烷盐酸(4584-46-7)质谱(MS) 二甲氨基氯乙烷盐酸(4584-46-7)红外图谱(IR1) 二甲氨基氯乙烷盐酸(4584-46-7)Raman光谱 二甲氨基氯乙烷盐酸(4584-46-7)核磁图( 1 HNMR) 二甲氨基氯乙烷盐酸(4584-46-7)红外图谱(IR2) 二甲氨基氯乙烷盐酸(4584-46-7)核磁图( 13 CNMR)
  • 有吸湿性。溶于水(20℃,2000g/L)和乙醇。有毒。有刺激性
  • 下游产品:2-氯-6-甲基苯甲醛,98% --> 1-(2-二甲基氨基乙基)哌嗪 --> 4-[2-(二甲胺基)乙氧基]苯甲醛 --> N'-苯甲基-N,N-二甲基乙二胺

系列性分类


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