Histamine dihydrochloride 组胺二盐酸盐

CAS 56-92-8 MFCD00012703

化学结构图

56-92-8
SMILES: Cl.Cl.NCCc1cnc[nH]1

化学属性

Mol. FormulaC5H11Cl2N3
Mol. Weight184.07
Density1.14
Melting Point249-252°C
TSCAYes
Solubility可溶
Appearance 类白色结晶或白色结晶性粉末。熔点 249-252℃,可溶于水。 powder

别名和识别编码

Chemical NameHistamine Dihydrochloride
CAS Number56-92-8
Alfabeta NameIMIDAZOLEETHANAMINEDIHYDROCHLORIDE H14---
MDL NumberMFCD00012703
Synonym Histamine (dihydrochloride) {LY} Histamine (dihydrochloride) {} {LY} Histamine (dihydrochloride) {} {} {LY} Histamine (dihydrochloride) {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {}
EC Number200-298-4
Beilstein Registry Number25,315
Reaxys-RN3624116
PubChem Substance ID5818
Merck Number4719
Chemical Name Translation组胺二盐酸盐
Wiswesser Line NotationT5M CNJ D2Z &GH 2
LabNetwork Molecule IDLN00001627
InChIInChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
Canonical SMILESNCCC1=CN=CN1.Cl.Cl
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分类

  • {SNA} Agonists, Amino Acid, Amino Acid Library, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, Histaminergics, Membrane Protein Biology Tools, Metabolic Libraries, Mistaminergics - Agonists, Neuroscience, Neurotransmission, Neurotransmitters, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
  • {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Substrates, H, Histamine-N-Methyltransferase,

产品应用

  • 多巴胺(dopamine)直接前体的天然异构体,酪氨酸羟化酶的产物

相关文献及参考

  • Fu, L.W., et al., Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors. Am. J. Physiol. 273(6 Pt 2) , 2726, (1997) 摘要
  • Merck:14,4719 Beilstein:25,315
  • Merck:14,4719
  • Merck 14 ,4719
  • Dale, H.H., et al.: J. Physiol., 41, 318 (1910); Oosting, E., et al.: Clin. Exp. Allergy, 20, 349 (1990); Hill, S.J., et al.: Pharmacol. Rev., 49, 253 (1997);

安全信息

Warnings IRRITANT
Signal word
GHS Symbol
WGK Germany2
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S37 Wear suitable gloves 戴适当手套;
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R42 May cause sensitisation by inhalation 吸入会产生过敏反应
  • R42/43
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
  • P302+
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P304+P341
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P307+P311
  • P308+P311
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P332+P317
  • P333+P313
  • P337+P313
  • P337+P317
  • P342+P311
  • P342+P316
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes Xn Xn,Xi Xi
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSMS1575000
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from mo
UN Number 3335
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1550 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   ACPMAP Actualites Pharmacologiques.  (Paris, France)  No.1-33, 1949-81. For
   publisher information, see JNPHAG.  Volume(issue)/page/year: 24,51,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 184 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >28 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JIDIAQ Journal of Infectious Diseases.  (Univ. of Chicago Press, Journals
   Div., POB 37005, Chicago, IL 60637)  V.1-    1904- Volume(issue)/page/year:
   42,473,1928

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2400 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 6,179,1963

其他信息

  • Alfa Aesar:二盐酸组胺,98+% Histamine dihydrochloride, 98+%(56-92-8)
  • Acros Organics:组胺二盐酸盐 Histamine dihydrochloride, 99%(56-92-8)
  • MSDS 信息:2-(4-Imidazolyl)ethylamine dihydrochloride(56-92-8).msds
  • MOL 文件:56-92-8.mol
  • TCI Shanghai:组胺二盐酸盐 Histamine Dihydrochloride,>;99.0%(T)(56-92-8)
  • 检测方法:T,NMR
  • F:1-8-9
  • 图谱信息:组胺二盐酸盐(56-92-8)核磁图( 1 HNMR) 组胺二盐酸盐(56-92-8)红外图谱(IR2) 组胺二盐酸盐(56-92-8)核磁图( 13 CNMR) 组胺二盐酸盐(56-92-8)质谱(MS) 组胺二盐酸盐(56-92-8)红外图谱(IR1)
  • 组胺二盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62013932 二盐酸组胺 5g 138元 2011/04/16 H0146 组胺二盐酸盐 Histamine Dihydrochloride 1G 130元 2011/04/16 H0146 组胺二盐酸盐 Histamine Dihydrochloride 25G 1220元
  • Hazard Note:Irritant
  • color:white to off-white
  • 用途一:生化试剂,用作测定组胺酶的底物。作为医药中间体用于药物制造等用途。
  • Sigma Aldrich:56-92-8(sigmaaldrich)

系列性分类


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