6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid 伊索克酸

CAS 55453-87-7 MFCD00242952

化学结构图

55453-87-7
SMILES: OC(=O)CC1=CC2=C(C=C1)OCC1C=CC=CC=1C2=O

化学属性

Mol. FormulaC16H12O4
Mol. Weight268.27
Melting Point140.0 to 142.0 deg-C

别名和识别编码

Chemical Name6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid
CAS Number55453-87-7
Alfabeta NameOXODIHYDRODIBENZOOXEPINYLACETICACID BE2116112[]()-------,,
MDL NumberMFCD00242952
Synonym NSC 300907 Isoxepac Artil 11-Oxo-6,11-dihydrodibenz[b,e]oxepin-2-acetic Acid HP 549 6,11-Dihydro-11-oxo-dibenz(b,e)oxepin-2-acetic acid 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic Acid P 720549
Wiswesser Line NotationT C676 BV IO JHJ E1VQ
Beilstein Registry Number1320243
LabNetwork Molecule IDLN00174124
Chemical Name Translation伊索克酸
Reaxys-RN1320243
Merck Number5237
PubChem Substance ID172088950
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Nonsteroidal anti-inflammatory.

相关文献及参考

  • Huston, G., et al.: Brit. J. Clin. Pharmacol., 11, 528 (1981),

安全信息

Warnings IRRITANT
RTECSHQ4110000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 227,142,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 227,142,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 227,142,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Gastrointestinal - ulceration or bleeding from small intestine
R

Hazard Class6.1
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
GHS Symbol
UN Number 2811
Signal word
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310+P330
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Oxepin 奥昔平

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