Propoxyphene Hydrochloride Salt 盐酸右丙氧芬

CAS 1639-60-7 MFCD00168119

化学结构图

1639-60-7
SMILES: CCC(=O)O[C@](Cc1ccccc1)(c1ccccc1)[C@H](C)CN(C)C.Cl

化学属性

Mol. FormulaC22H29NO2.ClH
Mol. Weight375.98
Melting Point165-1670C

别名和识别编码

Chemical Name2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-,propionate (ester), hydrochloride, (+)-
CAS Number1639-60-7
Synonym alpha-(+)-propoxyphenehydrochloride (+)-hlorid DEXTROPROPOXYPHENE HYDROCHLORIDE darvonhydrochloride Deprancol Dextropropoxyphene hydrochloride Darvon depronal 盐酸丙氧芬 d-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanolpropionatehydrochloride Develin d-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate develin 盐酸右丙氧芬 d-propoxyphenemonohydrochloride doraphen deprancol algaphan alpha-[2-(dimethylamino)-1-methylethyl]-alpha-phenyl-benzeneethanopropano doloxene (+)-1,2-diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutanehydrochloride DARVON doloxen Algafan Darvon hydrochloride (?S)-?-[(1R)-2-(Dimethylamino)-1-methylethyl]-?-phenylbenzeneethanol Propanoate Hydrochloride Depronal DEA限制 ?-(+)-Propoxyphene Hydrochloride d-propoxyphenehydrochloride ?-d-Propoxyphene Hydrochloride Algaphan PROPOXYPHENE HYDROCHLORIDE alpha-d-propoxyphenehydrochloride alpha-propoxyphenehydrochloride
MDL NumberMFCD00168119
Chemical Name Translation盐酸右丙氧芬
EC Number216-683-5
Wiswesser Line Notation2VOXR&1R&Y1&1N1&1 &GH -D
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Dextropropoxyphene is a controlled substance (opiate). Analgesic (narcotic). The ?-dl-and d-diastereoisomers possess marked analgesic activity in contrast to the ?-diastereoisomers which are substanti

相关文献及参考

  • Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),

安全信息

Packing GroupIII
Hazard Class6.1(b)
UN Number 3249
Restrict 精麻类化学品 {} 麻醉药品
RTECSEL3000000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - change in rate
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.1

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   JFSCAS Journal of Forensic Sciences.  (American Soc. for Testing and
   Materials, 1916 Race St., Philadelphia, PA 19103)  V.1-    1956-
   Volume(issue)/page/year: 19,72,1974

{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,332,1961

{

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SP

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1050 mg/kg
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   205,1220,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 225 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 123,705,1975

其他信息

  • MOL 文件:1639-60-7.mol

系列性分类

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