Neferine 4-(((S)-6,7-二甲氧基-2-甲基-1,2,3,4-四氢异喹啉-1-基)甲基)-2-(((R)-6-甲氧基-1-(4-甲氧基苄基)-2-甲基-1,2,3,4-四氢异喹啉-7-基)氧基)苯酚

CAS 2292-16-2 MFCD01707128

化学结构图

2292-16-2
SMILES: COc1ccc(C[C@@H]2c3cc(Oc4cc(C[C@H]5c6cc(OC)c(OC)cc6CCN5C)ccc4O)c(OC)cc3CCN2C)cc1

化学属性

Mol. FormulaC38H44N2O6
Mol. Weight625
Density1.185
Boiling Point
Melting Point

别名和识别编码

Chemical NameNeferine
Synonym (-)-Neferine 4′′-O-Methylliensinine 4-[[(1R)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol Methylliensinine Neferin Neferine neferine 甲基莲心碱
CAS Number2292-16-2
Chemical Name Translation4-(((S)-6,7-二甲氧基-2-甲基-1,2,3,4-四氢异喹啉-1-基)甲基)-2-(((R)-6-甲氧基-1-(4-甲氧基苄基)-2-甲基-1,2,3,4-四氢异喹啉-7-基)氧基)苯酚
Beilstein Registry Number1523459
InChIKeyMIBATSHDJRIUJK-ROJLCIKYSA-N
PubChem Substance ID159654
InChIInChI=1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1
MDL Number
EC Number
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Chaperonins and Heat Shock Proteins, Heat Shock and Related Proteins, Kinase/Phosphatase Biology, MAPK-Activated Protein Kinase (MAPKAP Kinase), New Products, Nitric Oxide and Cell Stress, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors

相关文献及参考

  • Zhang, X., et al., Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. Eur. J. Pharmacol. 677 , 47-54, (2012)
  • Peng, Z.Y., et al., Protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the DDAH-ADMA pathway. Can. J. Physiol. Pharmacol. 89 , 289-294, (2011)
  • Li, X.C., et al., Neferine inhibits angiotensin II-stimulated proliferation in vascular smooth muscle cells through heme oxygenase-1. Acta Pharmacol. Sin. 31 , 679-686, (2010)

安全信息

RTECSSM9495000
WGK Germany3
Storage condition 储存温度2-8℃ 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 19,217,1988

GHS Symbol
UN Number
Hazard Codes
Signal word
Safety Statements
Risk Statements
Precautionary statements
Packing Group

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Nitric Oxide and Cell Stress - Cell Signaling and Neuroscience
  5. Cell Stress - Nitric Oxide and Cell Stress
  6. Chaperonins and Heat Shock Proteins - Cell Stress
  7. Heat Shock and Related Proteins - Chaperonins and Heat Shock Proteins
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. MAPK-Activated Protein Kinase (MAPKAP Kinase) - Serine/Threonine Kinase Inhibitors

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