Tolperisone hydrochloride 甲苯哌丙酮盐酸盐

CAS 3644-61-9 MFCD00058211

化学结构图

3644-61-9
SMILES: Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1.Cl

化学属性

Mol. FormulaC16H24ClNO
Mol. Weight282
Melting Point171.0 to 174.0 deg-C

别名和识别编码

Chemical NameTolperisone hydrochloride
CAS Number3644-61-9
Synonym ######## 1-Piperidino-2-methyl-3-(4-methylphenyl)propan-3-one hydrochloride 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone hydrochloride 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI) 1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride 2,4'-DIMETHYL-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE 2,4'-Dimethyl-3-piperidinopropiophenone hydrochloride 2,4'-dimethyl-3-piperidinopropiophenone 2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride 2,4’-dimethyl-3-piperidino-propiophenonhydrochloride 2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one 盐酸盐 2-Methyl-3-piperidino-1-p-tolylpropan-1-one hydrochloride 2-methyl-1-(4-m 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone
MDL NumberMFCD00058211
EC Number222-876-5
Chemical Name Translation甲苯哌丙酮盐酸盐
Reaxys-RN7054592
PubChem Substance ID92965
Merck Number9522
Wiswesser Line NotationT6NTJ A2VR B1 D1 &GH
LabNetwork Molecule IDLN00195955
InChIInChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Ion Channels, Monovalent Ion Channels, Other Sodium Channel Modulators, Sodium Channel Modulators, T, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Merck, Monovalent Ion Channels, Other Sodium Channel Modulators, Sodium Channel Modulators, T, Voltage-gated Ion Channels
  • {SNA} Approved Therapeutics/Drug Candidates, Ion Channels, Merck, Monovalent Ion Channels,

产品应用

  • Used as a muscle relaxant.

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P352
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
RTECSUH1575500
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Hazard Codes Xn
Risk Statements
  • R52/53
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition Room temp
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 358 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 107,705,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,531,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle weakness
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,809,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 655 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 24,1637,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent -

其他信息

  • TCI Shanghai:甲苯哌丙酮 盐酸盐 Tolperisone Hydrochloride,>;99.0%(T)(3644-61-9)
  • 甲苯哌丙酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1319 盐酸甲苯哌丙酮 Tolperisone Hydrochloride 25G 580元
  • MOL 文件:3644-61-9.mol
  • 用途一:为中枢性肌松剂和血管扩张药
  • 上游原料:六氢吡啶 --> 对甲基苯丙酮
  • 图谱信息:甲苯哌丙酮(3644-61-9)核磁图( 1 HNMR) 甲苯哌丙酮(3644-61-9)红外图谱(IR1) 甲苯哌丙酮(3644-61-9)核磁图( 13 CNMR) 甲苯哌丙酮(3644-61-9)质谱(MS) 甲苯哌丙酮(3644-61-9)红外图谱(IR2)
  • Sigma Aldrich:3644-61-9(sigmaaldrich)

系列性分类


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