2-Imidazolidinone, 1-((5-nitrofurfurylidene)amino)-

CAS 555-84-0 MFCD00057258

化学结构图

555-84-0
SMILES: O=C1NCCN1N=Cc1ccc([N+](=O)[O-])o1

化学属性

Mol. FormulaC8H8N4O4
Mol. Weight224.20

别名和识别编码

Chemical Name2-Imidazolidinone, 1-((5-nitrofurfurylidene)amino)-
Wiswesser Line NotationT5OJ BNW E1UN- CT5MVNTJ
Synonym Renafur Oxifuradene NF 246 2-Imidazolidinone, 1-(((5-nitro-2-furanyl)methylene)amino)- Nifuradine Nifuradene N-(5-Nitro-2-furfurylidene)-1-amino-2-imidazolidone Oxyfuradene 1-((5-Nitrofurfurylidene)amino)-2-imidazolidinone Oxafuradene N-(5-Nitro-2-furfurylideneamino)-2-imidazoaidinone NSC-6470
CAS Number555-84-0
Beilstein Registry Number0384793
PubChem Substance ID9568055
InChIInChI=1S/C8H8N4O4/c13-8-9-3-4-11(8)10-5-6-1-2-7(16-6)12(14)15/h1-2,5H,3-4H2,(H,9,13)/b10-5+
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 34 gm/kg/46W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Skin and Appendages - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   51,403,1973

RTECSNJ0875000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 538 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - respiratory depression
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16,663,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1681 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

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