2-Chloroethyl-N-nitrosourethane

CAS 6296-45-3 MFCD01737933

化学结构图

6296-45-3
SMILES: CCOC(=O)N(CCCl)N=O

化学属性

Mol. FormulaC5H9ClN2O3
Mol. Weight180.61

别名和识别编码

Chemical NameCarbamic acid, (2-chloroethyl)nitroso-, ethyl ester
Wiswesser Line NotationON2OVM2G
Synonym N-(2-Chloroethyl)-N-nitrosocarbamate ethyl ester 2-Chloroethyl-N-nitrosourethane TL 154 N-(beta-Chloroethyl)-N-nitrosourethan Ethyl N-(beta-chloroethyl)-N-nitrosocarbamate Ethylester kyseliny N-(2-chlorethyl)-N-nitrosokarbaminove
CAS Number6296-45-3
Beilstein Registry Number1781530
InChIKeyNFCXERZWGPTYNW-UHFFFAOYSA-N
PubChem Substance ID22732
InChIInChI=1S/C5H9ClN2O3/c1-2-11-5(9)8(7-10)4-3-6/h2-4H2,1H3
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   31,573,1971

RTECSEZ2100000 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 330 mg/m3/10M
TOXIC EFFECTS :
   Behavioral - irritability
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NDRC** National Defense Research Committee, Office of Scientific Research
   and Development, Progress Report.  Volume(issue)/page/year:
   NDCrc-132,APR1942

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - changes in structure or function of esophagus
   Gastrointestinal - alteration in gastric secretion
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   31,573,1971

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6500 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Lungs, Thorax, or Respiration - pleural effusion
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   31,573,1971

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 330 mg/m3/10M
TOXIC EFFECTS :
   Behavioral - irritability
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NDRC** National Defense Research Committee, Office of Scientific Resear

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,175,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 nmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,175,1983

系列性分类

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