P-gp

下级目录

GNE-317

Cabazitaxel

Laniquidar

ONT-093

Milataxel

Genz-123346 free base

Avanbulin

TAK-285

Annamycin

IXABEPILONE

目录项下的产品

1394076-92-6

1394076-92-6 / MFCD494076926
GNE-317
GNE-317游离态

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

183133-96-2

183133-96-2 / MFCD83133962
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
β-[[（1,1-二甲基乙氧基）羰基]氨基]-α-羟基-苯丙酸,(乙酰氧基)-12-(苯甲酰氧基)- 十二氢-11-羟基-4,6-二甲氧基-4,8,8,13,13-四甲基-5-氧代-7,11-亚甲基-1H-环癸烷[3,4]苯并[1,2-b]氧杂-9-基酯

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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中华人民共和国
√

197509-46-9

197509-46-9 / MFCD97509469
Laniquidar

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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216227-54-2

216227-54-2 / MFCD16227542
ONT-093, also known as OC-144-093, is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. OC144-093 is the least non-specifically toxic Pgp inhibitor described to date, with an average cytostatic IC50 of >60 microM in 15 cell types. OC144-093 may represent an ideal candidate for use in enhancement of AED blood-brain barrier penetration.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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393101-41-2

393101-41-2 / MFCD93101412
Milataxel

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

491833-30-8

491833-30-8 / MFCD91833308
Genz-123346 free base

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

798577-91-0

798577-91-0 / MFCD98577910
Avanbulin, also known as BAL27862, is a novel synthetic potent inhibitor of tubulin polymerization that induces cancer cell death. BAL27862 is a novel microtubule-destabilizing drug that is currently undergoing phase I clinical evaluation as the prodrug BAL101553. BAL27862 elicits a unique microtubule (MT) phenotype, distinct from paclitaxel, vinblastine and colchicine, has broad in vitro anti-proliferative activity against a diverse range of human tumor lines (low nM IC50s) and induces significant antitumor responses in a range.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

871026-44-7

871026-44-7 / MFCD71026447
TAK-285
N-(2-(4-((3-氯-4-[3-(三氟甲基)苯氧基)苯基)氨基)-5H-吡咯并[3,2-d]嘧啶-5-基)乙基)-3-羟基-3-甲基丁酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

92689-49-1

92689-49-1 / MFCD00914599
Annamycin is a semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. This agent circumvents multidrug-resistance (MDR) transporters, including P-glycoprotein (P-gp).

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

219989-84-1

219989-84-1 / MFCD04307791
Ixabepilone
(1S,3S,7S,10R,11S,12S,16R)-7,11-二羟基-8,8,10,12,16-五甲基-3-((E)-1-(2-甲基噻唑-4-基)丙烷-1-烯-2-基)-17-氧杂-4-氮杂双环并[14.1.0]十七烷-5,9-二酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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