Dimefline Hydrochloride 8-((二甲氨基)甲基)-7-甲氧基-3-甲基-2-苯基-4H-色满-4-酮盐酸盐

CAS 2740-04-7 MFCD00242918

化学结构图

2740-04-7
SMILES: COc1ccc2c(=O)c(C)c(-c3ccccc3)oc2c1CN(C)C.Cl

化学属性

Mol. FormulaC₂₀H₂₁NO₃ • HCl
Mol. Weight
Melting Point>204°C (dec.)
Boiling Point

别名和识别编码

Chemical NameDimefline Hydrochloride
CAS Number2740-04-7
Synonym ######## 4H-1-Benzopyran-4-one, Dimefline Hydrochloride
Chemical Name Translation8-((二甲氨基)甲基)-7-甲氧基-3-甲基-2-苯基-4H-色满-4-酮盐酸盐
Wiswesser Line NotationT66 BO EVJ CR& D1 IO1 J1N1&1 &GH
PubChem Substance ID443942
InChIInChI=1S/C20H21NO3.ClH/c1-13-18(22)15-10-11-17(23-4)16(12-21(2)3)20(15)24-19(13)14-8-6-5-7-9-14;/h5-11H,12H2,1-4H3;1H
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分类

  • Amines
  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Dimefline is a new respiratory stimulant drug.

相关文献及参考

  • Edwards, J.M., et al.: J. Nat. Prod., 42, 85 (1979),
  • Setnikar, I., et al.: Arzneim.-Forsch., 11 1109 (1961),

安全信息

RTECSLK8575000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 24,1239,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 128,176,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,345,1982

TYPE OF TEST            : LD50 -

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 128,176,1960

Storage condition 4

系列性分类

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