Potassium Bis(Trimethylsilyl)Amide 双(三甲基硅烷基)氨基钾

CAS 40949-94-8 MFCD00010330


SMILES: C[Si](C)(C)N([K])[Si](C)(C)C


Refractive index1.4920
Flash Point-14°(6°F)
Boiling Point66°
Vapor Density3.2 (vs air)
Vapor Pressure54 mmHg ( 25 °C)
Mol. FormulaC6H18KNSi2
Mol. Weight199.48


Chemical NamePotassium Bis(Trimethylsilyl)Amide
Synonym 六甲基二硅氮烷 钾盐 溶液 双(三甲基硅基)氨基钾, 20% W/W, 0.91M IN THF 双(三甲基硅烷基)氨基钾 溶液 Potassium hexamethyldisilazide 六甲基二硅基胺基钾 溶液 六甲基二硅基胺基钾 溶液 六甲基二硅氮烷 钾盐 溶液
MDL NumberMFCD00010330
PubChem Substance ID3251421
Beilstein Registry Number4006754
EC Number424-100-2
CAS Number40949-94-8
Chemical Name Translation双(三甲基硅烷基)氨基钾
LabNetwork Molecule IDLN00163929
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  • {SNA} 12 Principles Aligned Products, 25mL Sure/Seal Reagents, Acids & Bases, Bases, Chemical Synthesis, Greener Alternative Products, Orga
  • {SNA} Acids & Bases,
  • {SNA} Chemical Synthesis, Organometallic Reagents, Organosilicon, Others
  • {SNA} 12 Principles Aligned Products, 25mL Sure/Seal Reagents, Acids &


  • ⑴.常温常压条件下为液体。
  • ⑵.非亲核性强碱。
  • ⑶.医药中间体,主要用于合成头孢抗生素的生产。
  • 非亲核性强碱。


  • Also used in the Wittig reaction, to give Li salt-free product distribution for selective (Z)-alkene formation: J. Org. Chem., 45, 4260 (1980). Has also been used with 18-crown-6 for selective formation of (Z)-ɑß-unsaturated esters from phosphonates: Tetrahedron Lett., 24, 4405 (1983).
  • Sterically hindered strong base, compare Sodium bis(trimethyl­silyl)­amide, L13352 and Lithium bis(trimethyl­silyl)­amide, L15012. Used in the generation of K enolates, preferred to their Li or Na counterparts in some reactions, see e.g.: Tetrahedron Lett., 32, 1779 (1991); J. Am. Chem. Soc., 109, 6881 (1987); 111, 1063 (1989).


WGK Germany3
GHS Symbol
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P403+P233
  • P305+P351+P338+P310
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P330+P331+P310
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P370+P378
  • P304+P340
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P301+P310
  • P301+P310+P331
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P308+P311
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Signal word
Packing GroupII
UN Number UN2924
Risk Statements
  • R14 Reacts violently with water 遇水会猛烈反应
  • R11 Highly flammable 非常易燃
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R48/20
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
  • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
  • R34 Causes burns 会导致灼伤
  • R19 May form explosive peroxides 可能生成易爆的过氧化物质
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
  • S30 Never add water to this product 切勿将水加入该产品中;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
  • S8 Keep container dry 保持容器干燥;
Storage condition Refrigerator Air & Moisture Sensitive 充氩保存
Hazard Codes F,C
Hazard Class3/8
Restrict -


  • ⑴.储存于阴凉、干燥、通风良好的专用库房内,远离火种、热源。 ⑵.出现意外或者感到不适,立刻到医生那里寻求帮助(最好带去产品容器标签)。 ⑶.操作时穿戴合适的防护服、手套并使用防护眼镜或者面罩。 ⑷.未经政府许可禁止排入地下水,水道或者污水系统。