(3-Chlorophenyl)Carbonohydrazonoyl Dicyanide N-(3-氯苯基)羰基亚肼基二氰化物

CAS 555-60-2 MFCD00001848

化学结构图

555-60-2
SMILES: N#CC(C#N)=NNc1cccc(Cl)c1

化学属性

Mol. FormulaC9H5ClN4
Mol. Weight204.62 g/mol
Melting Pointca 175° dec.
TSCAYes
Solubilitymethanol: 10 mg/mL, clear, very deep yellow
Appearance powder

别名和识别编码

Chemical Name(3-Chlorophenyl)Carbonohydrazonoyl Dicyanide
MDL NumberMFCD00001848
CAS Number555-60-2
Synonym BUTTPARK 91\04-41 CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE CARBONYL CYANIDE M-CHLOROPHENYL & CARBONYL CYANIDE M-CHLOROPHENYL-HYDRAZONE CCCP {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID2603
EC Number209-103-7
Beilstein Registry Number1842102
Chemical Name TranslationN-(3-氯苯基)羰基亚肼基二氰化物
LabNetwork Molecule IDLN01820648
InChIKeyUGTJLJZQQFGTJD-UHFFFAOYSA-N
InChIInChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
Canonical SMILESN#C/C(C#N)=N/NC1=CC=CC(Cl)=C1
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, 一氧化氮和细胞应激, 生物活性小分子, 线粒体抑制剂, 细胞信号转导和神经科学, 细胞应激, 细胞生物学
  • {SNA} Bioactive Small Molecules, C-CH, Cell Signaling and Neuroscience, Cell Stress, Mitochondrial Inhibitors, Nitric Oxide and Cell Stress, 细胞生物学
  • {SNA} Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Mitochondrial Inhibitors, Nitric Oxide and Cell Stress
  • {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Cell Stress,

相关文献及参考

  • [2]. Sinha D, et al. Synergistic efficacy of Bisbenzimidazole and Carbonyl Cyanide 3-Chlorophenylhydrazonecombination against MDR bacterial strains. Sci Rep. 2017 Mar 17;7:44419.
  • [3]. Kawamoto A, et al. Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure. PLoS One. 2015 Jan 16;10(1):e0117091.
  • [4]. Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080.
  • Uncoupler of oxidative phosphorylation: Biochem. Biophys. Acta, 394 145 (1975); Biochemistry, 17, 2245 (1978).
  • [1]. Kwon D, et al. Carbonyl cyanide 3-chl
  • [1]. Kwon D, et al. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. Biochem Biophys Res Commun. 2017 Aug 30. pii: S0006-291X(17)31704-7.

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301+H311+H331
  • H330 Fatal if inhaled 吸入致命
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSFG5600000
Precautionary statements
  • P301+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Packing GroupIII
UN Number UN 2811 6.1/PG 3 UN3439
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R25 Toxic if swallowed 吞咽有毒
Hazard Codes T
Hazard Class6.1
Storage condition 2-8°C {Chemicalbook} 2-8°C

其他信息

  • Acros Organics:羰基氰基3-氯苯腙/羰基氰化氯苯腙/CCCP Carbonyl cyanide 3-chlorophenylhydrazone, 99+%(555-60-2)
  • 羰基氰化氯苯腙价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 228130010 羰基氰化氯苯腙 Carbonyl cyanide 3-chlorophenylhydrazone 99+% 1 GR 1422元 2010/06/21 228131000 羰基氰化氯苯腙 Carbonyl cyanide 3-chlorophenylhydrazone 99+% 100 MG 285元 2010/05/25 L06932 羰基氰酯-3-氯苯基腙, 98% Carbonyl cyanide 3-chlorophenylhydrazone, 98% 500mg 563元
  • MOL 文件:555-60-2.mol
  • Sigma Aldrich:555-60-2(sigmaaldrich)
  • color:yellow to orange
  • Alfa Aesar:羰基氰酯-3-氯苯基腙,98% Carbonyl cyanide 3-chlorophenylhydrazone, 98%(555-60-2)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. C-CH - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Nitric Oxide and Cell Stress - Cell Signaling and Neuroscience
  5. Cell Stress - Nitric Oxide and Cell Stress
  6. Mitochondrial Inhibitors - Cell Stress
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Organic Covalent Modifiers - Enzyme Inhibitors by Type
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Hydrazones - Nitrogen Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Nitric Oxide and Cell Stress
  5. Cell Stress
  6. Antioxidants and Cytoprotectants
  1. Medical Research Areas
  2. Metabolism
  3. Mitochondrial Metabolism  (线粒体代谢)

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