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分类

• Building Blocks, C1 to C5, Chemical Synthesis, Cyanides/Nitriles, Nitrogen Compounds, Organic Building Blocks
• {uni_hamburg} no charge; 1fragment
• {SA} Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Environmental Standards, Nitriles, P, P-S, PON - PT, Volatiles/ Semivolatiles
• {SNA} Alphabetical Index of Analytical Standards, Chemical Class, Alpha Sort, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards,

相关文献及参考

• Merck 14 ,7827
• Beil. 2 ,IV,728
• Aldrich MSDS 1 , 1546:B / Corp MSDS 1 (2), 2959:A / FT-IR 1 (1), 837:B / FT-IR 2 (1), 1422:B / FT-NMR 1 (1), 1351:B / IR-Spectra (2), 444:B / IR-Spectra (3), 500:B / NMR-Reference 2 (1), 695:C / RegBook 1 (1), 987:C / Sax 6 , 2300 / Structure Index 1 , 154:C:1 / Vapor Phase 3 , 795:B
• Short: II/14a Title: Molecular Constants: Diamagnetic Molecules Author: Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14a Page: 1-788 Year: 1982 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-11365-7 ISBN: 978-3-540-11365-2 Internet Resource: DOI:10.1007/b19966 RefComment: 196 figs., XI
• Short: II/24B Title: Molecular Constants mostly from Microwave, Molecular Beam, and Sub-Doppler Laser Spectroscopy: Rotational, Centrifugal Distortion and Related Constants of Diamagnetic Asymmetric Top Molecules Author: Demaison, J.; Vogt, J.; Wlodarczak, G. Editor: Hüttner, W. Source: Landolt-Börnstein, New Series Volume: II/24B Year: 2000 Keyword: Diamagnetics Diatomics; Linear Symmetric Rotors; Molecular Constants; Molecules ISBN: 3-540-65345-7 ISBN: 978-3-540-65345-5 Internet Resource: DOI:10.1007/b58835 RefComment: VIII, 525 pages. Hardcover Abstract: Volume II/24 presents the spectroscopic data on diamagnetic and paramagnetic molecules as well as on molecular ions and radicals up to date considering the publications up to and partly including 1997. The spectroscopic information collected in this volume has been obtained principally from gas phase microwave measurements. Volume II/24 is a supplement to volumes II/4, II/6, II/14, and II/19 and is planned to appear in five subvolumes, the last of which will contain the substance index taking into account all molecules worked at since 1967 in the volumes

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 163 ppm/1H
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 18,991,1981

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 1,251,1889

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   59,589,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 51 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 259,165,1991

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 15100 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 224,31,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 238 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 23,325,1981

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 ppm/6H
SEX/DURATION            : female 6-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   20,365,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1120 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FAATDF Fundamental and Ap

其他信息

• 凝固点:-93℃
• 可燃性危险特性:遇明火、高温、氧化剂易燃, 燃烧产生有毒氮氧化物烟雾
• 职业标准:TWA 6 PPM
• 外观性质:无色液体，有醚样气味。
• MSDS 信息:丙腈(107-12-0).msds
• 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
• 爆炸物危险特性:与空气混合可爆
• MOL 文件:107-12-0.mol
• 毒性分级:剧毒
• 急性毒性:口服- 大鼠 LD50: 39 毫克/ 公斤; 口服- 小鼠 LD50: 35.8 毫克/ 公斤
• 下游产品:异丙威 --> 2-乙基-5-嘧啶甲醛 --> 丙脒盐酸盐 --> 2-乙基-4-甲基咪唑
• 类别:易燃液体
• 上游原料:高锰酸钾 --> 镍 --> 丙烯腈 --> 4-氯苯甲醛 --> 硅凝胶 --> 丙酰胺 --> 1,4-二氰基丁烷 --> 磷酸铜 --> 1,4-二氨基-2,3-二氰基蒽醌
• 丙腈价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80108724 丙腈(剧毒) 25ml 28.1元 2011/08/23 80108726 丙腈(剧毒) 100ml 40元 2011/08/23 K7667102 丙腈（剧毒）　标准品 5ml 980元
• 用途二:本品用作有机合成原料、溶剂和树脂添加剂。少量用作医药原料，主要合成解痉药2,4,6-三羟基苯丙酮、磺胺异噁唑等药物。也用作色谱分析标准物质。经催化加氢可得丙胺。还用作农药除草剂的中间体。
• 图谱信息:丙腈(107-12-0)质谱(MS) 丙腈(107-12-0)红外图谱(IR1) 丙腈(107-12-0)核磁图( 13 CNMR) 丙腈(107-12-0)核磁图( 1 HNMR)
• 方法一:1.由丙烯腈直接催化加氢制得。将丙烯腈在催化剂磷酸铜、铑、雷尼镍存在下于气相或液相中进行加氢反应，制得丙腈。2.丙烯腈经电解加氢二聚合制备己二腈时，在制得双氰乙基醚的同时，丙腈作为副产品制得。3.由丙酸氨化而得，将氨气通入装有硅胶的铁管内，以电热丝加热，维持400℃通氨活化8h，调好氨气流量并慢慢滴入丙酸，通过320-380℃的预热器进入反应管道，温度控制在380-400℃。生成的粗丙腈的冷凝瓶内分为两层，上层为溶有12%的丙腈水溶液。分出水层，丙腈中加入少许固体高锰酸钾，摇匀，放置约4h，待颜色不褪便可将上层液倾入另一容器中，加入碳酸钾进行干燥，在搅动下放置8h，进行分馏（分馏柱内充磁环），收集95.8-97.5℃的馏分即得成品，产率59.8%。此外，丙酰胺与五氧化二磷作用也可制得丙腈。
• 刺激数据:眼睛- 兔子 100 毫克/ 24小时 中度; 皮肤- 兔子5000 毫克/ 24小时 轻度
• 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
• Acros Organics:丙腈 Propionitrile, extra pure, 99%(107-12-0)
• Alfa Aesar:丙腈,99% Propionitrile, 99%(107-12-0)
• Sigma Aldrich:107-12-0(sigmaaldrich)
• 用途一:用于医药中间体、有机合成、溶剂和树脂添加剂等