2-Chlorophenol 2-氯苯酚

CAS 95-57-8 MFCD00002159

化学结构图

95-57-8
SMILES: OC1CCCCC1Cl

化学属性

Mol. FormulaC6H5ClO
Mol. Weight128.56
Refractive index1.5570 to 1.5610
Boiling Point175-176
Density1.241
Melting Point8
Flash Point63.89°C
TSCAYes
Solubility28.5 G/L (20 ºC)
Stability对光敏感
pH:A

别名和识别编码

Chemical Name2-Chlorophenol
CAS Number95-57-8
PubChem Substance ID7245
EC Number202-433-2
Beilstein Registry Number1905114
MDL NumberMFCD00002159
Reaxys-RN1905114
Merck Number2154
Synonym 2-Chlorophenol {LY} 2-Chlorophenol 2-Chlorphenol 2-chloro-1-hydroxybenzene 2-chloro-pheno 2-chloro-phenol 2-chlorophenol(o-chlorophenol) 2-氯-1-羟基苯 2-氯苯酚,98+% 2-氯苯酚;邻氯苯酚;邻氯苯酚溶液;2-氯-1-羟基苯;2-羟基氯苯;邻羟基氯苯 2-氯酚 2-羟基氯苯 o-Chlorophenic acid o-Chlorphenol CHLOROPHENOL(O-) Phenol, o-chloro- Phenol, o-chloro- RCRA waste number U048 Rcra waste number U048 o-Chlorophenol o-chloro-pheno o-chlorophenicacid phenol, 2-chloro- pine-odisinfectant rcrawastenumberu048 {} {LY} 2-Chlorophenol {} {} {LY} 2-Chlorophenol {} {} {} {LY} 2-Chlorophenol {} {} {} {} {LY} 2-Chlorophenol {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {LY} 2-Chlorophenol {} {}
Chemical Name Translation2-氯苯酚
Wiswesser Line NotationQR BG
LabNetwork Molecule IDLN00200298
InChIInChI=1S/C6H5ClO/c7-5-3-1-2-4-6(5)8/h1-4,8H
Canonical SMILESOC1=CC=CC=C1Cl
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分类

  • {SA} Building Blocks, C6 to C8, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Phenols
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, C, CH, Chromatography, Environmental Standards,

产品应用

  • 有机合成，染料制造，杀菌剂。

相关文献及参考

  • Short: II/25D
  • Merck: 14,2154 Beilstein:6,183
  • Merck: 14,2154
  • Short: II/14a
  • Has been used as a reagent for the protection of OH-groups in oligonucleotide synthesis. A study of various cleavage methods showed that the tetramethylguanidine salts of either 4-nitrobenzaldoxime or pyridine-2-carboxaldoxime gave the best results: Tetrahedron Lett., 2727 (1978).

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302+H312+H332
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 6.1 Xn;N
RTECSSK2625000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338+P310
  • P308+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
UN Number 2021 2021/2905 UN 2021 6.1/PG 3 UN2021
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
  • R51/53
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
Packing GroupIII
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4800 mg/kg/12W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   19,413,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 13,20,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 2,76,1943

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 235 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,868,1975

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1580 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Lungs, Thorax, or Respiration - pulmonary emboli
   Liver - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Sci

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 800 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 182,135,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4550 mg/kg
SEX/DURATION            : female 70 day(s) pre-mating
                          female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 46,137,1982

Restrict 危险品

其他信息

  • 上游原料:次氯酸钠 --> 2,4-二氯酚
  • 下游产品:邻苯二酚 --> 2,4-二氯酚 --> 4-
  • 2-氯苯酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80034828 2-氯苯酚 500ml 47.3元 2010/06/21 180995000 2-氯苯酚 2-Chlorophenol 98+% 500 GR 406元 2010/06/21 180990025 2-氯苯酚 2-Chlorophenol 98+% 2.5 KG 1493元
  • 图谱信息:2-氯苯酚(95-57-8)Raman光谱 2-氯苯酚(95-57-8)核磁图( 13 CNMR) 2-氯苯酚(95-57-8)质谱(MS) 2-氯苯酚(95-57-8)红外图谱(IR1) 2-氯苯酚(95-57-8)核磁图( 1 HNMR)
  • 方法二:（1）由苯酚钠经氯化、酸化而得。搅拌苯酚钠、水及冰的混合物，于20℃以下慢慢加次氯酸钠溶液，控制温度在20℃以下，室温放置过夜，搅拌下加浓盐酸酸化至pH为2，水洗一次，再用5%碳酸钠溶液洗至洗液pH为4-5，冷却后，分出油层，进行常压分馏，再经减压蒸馏而得成品。（2）由苯酚用氯气氯化。在搅拌下将熔融的苯酚加入苯中，在26±2℃通入氯气，至氯
  • {Chemi
  • 有不愉快的刺激性气味。易溶于醇、醚、氯仿、甘油、挥发油类和苛性碱溶液，微溶于水。低毒，半数致死量（大鼠，经口）670mg/kg。有腐蚀性。
  • 方法一:邻氯苯酚是生产对氯苯酚的联产品，用苯酚氯化得到的
  • {Chemicalboo
  • 方法一:邻氯苯酚是生产对氯苯酚的联产品，用苯酚氯化得到的是邻位和对位的氯代苯酚，经分离可以得到
  • 下游产品:邻苯二酚 --> 2,4-二氯酚 --> 4-氯苯酚 --> 呋喃酚 --> 丙溴磷 --> 2,6-二氯苯酚 --> 3-氯苯酚 --> {2-[6-(2-氯苯氧基)-5-氟嘧啶-4-基氧]苯基}(5,6-二氢-1,4,2-二噁嗪-3-基)甲酮O-甲基肟 --> 2-(三甲基硅)苯基三氟甲烷磺酸盐 --> 4
  • {Che
  • 下游产品:邻苯二酚 --> 2,4-二氯酚 --> 4-氯苯酚 --> 呋喃酚 --> 丙溴磷 --> 2,6-二氯苯酚 --> 3-氯苯酚 --> {2-[6-(2-氯苯氧基)-5-氟嘧啶-4-基氧]苯基}(5,6-二氢-1,4,2-二噁嗪-3-基)甲酮O-甲基肟 --> 2-(三甲基硅)苯基三氟甲烷磺酸盐 --> 4-溴-2-氯苯酚 --> 4-溴-2,6-二氯酚 --> 氯
  • 类别:农药
  • 方法二:（1）由苯酚钠经氯化、酸化而得。搅拌
  • F:9
  • 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
  • 酚类单一化合物标准液
  • TCI Shanghai:2-氯苯酚 2-Chlorophenol,>;98.0%(GC)(95-57-8)
  • 用途五:有机合成，染料制造，杀菌剂。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。
  • 可燃性危险特性:明火可燃; 高热放出有毒氯化物气体
  • Sigma Aldrich:95-57-8(sigmaaldrich)
  • 用途三:用于有机合成。邻氯酚经光气化得到氯甲酸邻氯苯酯，是氨基甲酸酯类杀虫剂害扑威的中间体。
  • 毒性分级:高毒
  • {Chemic
  • 用途二:邻氯苯酚是杀虫剂丙溴磷的中间体。
  • 用途一:用于医药、农药和染料及其他有机合成原料
  • Alfa Aesar:2-氯苯酚,99% 2-Chlorophenol, 99%(95-57-8)
  • 急性毒性:口服- 大鼠 LD50: 670 毫克/ 公斤; 口服- 小鼠 LD50: 345 毫克/ 公斤
  • 用途四:有机合成，染料制造，杀菌剂。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  6. C6 to C8 - Phenols
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CH - C
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Method Specific - Analytical Standards
  4. European Community: ISO, DIN and DL 152 - Method Specific
  5. DL 152 (ex DM 471) - European Community: ISO, DIN and DL 152
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Aromatic alcohols 芳香醇
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers