2-Bromoethanol 2-溴乙醇

CAS 540-51-2 MFCD00002827

化学结构图

540-51-2
SMILES: OCCBr

化学属性

Mol. FormulaC2
Mol. Weight125
Refractive index1.4880 to 1.4920
Density1.763
Flash Point>110°(230°F)
TSCAYes
Boiling Point56-57
Melting Point-80°C
Vapor Density4.3 (vs air)
Vapor Pressure2.4 mmHg ( 20 °C)
SolubilitySoluble in water
Stability对热、湿度及光敏感
pH:A

别名和识别编码

Chemical Name2-Bromoethanol
CAS Number540-51-2
EC Number208-748-1
Reaxys-RN878140
Merck Number3792
Beilstein Registry Number878140
PubChem Substance ID10898
MDL NumberMFCD00002827
Synonym -Bromoethylalcohol 1-Bromo-2-ethanol 1-Bromo-2-hydroxyethane 2-BROMOETHANOL, 1000MG, NEAT 2-Bromethanol 2-Bromo Ethenol 2-Bromoethanol 2-Bromoethyl alcohol 2-bromo-1-ethanol 2-bromoetanol 2-hydroxyethylbromide 2-溴乙醇 Bromoethanol CH2BrCH2OH(trans) ETHYLENE BROMOHYDRIN Ethanol, 2-bromo- Ethylenbromhydrin Ethylene bromohydrin Ethylene bromohydrin2-Hydroxyethyl bromide ethylene bromohydrine glycolbromohydrin Β-溴乙醇 亚乙基溴醇 亚乙基溴醇; 溴乙醇; 2-溴代乙醇 溴乙醇
Chemical Name Translation2-溴乙醇
Wiswesser Line NotationQ2E
LabNetwork Molecule IDLN00195719
InChIInChI=1S/C2H5BrO/c3-1-2-4/h4H,1-2H2
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分类

  • {SNA} Alcohols,
  • {SNA} A-B, Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BI - BZ, Bromo, Chemical Class,
  • {uni_hamburg} no charge; alcohol; 1fragment
  • A-B, ASTM 5578: Analysis of Ethylene Oxide in Air, ASTM Air Monitoring, Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, B, BI - BZ, Bromo, Chemical Class, Chromatography, Environmental Standards, Halogenated, Method Specific, Volatiles/ Semivolatiles
  • {SNA} Alcohols,

产品应用

  • 可用于硝基芳烃（PcFe(II)/NaBH4/2-溴乙醇催化体系）的选择还原反应。

相关文献及参考

  • Carboxylic acids protected as their 2-bromoethyl esters are readily deprotected by cleavage with sodium trithiocarbonate: Synthesis, 715 (1974). 2-Bromoethyl esters of amino acids have been cleaved by conversion with NaI (Finkelstein) to the corresponding iodo esters, followed by reductive cleavage with Zn in DMF: Chem. Ber., 112, 2145 (1979); Angew. Chem. Int. Ed., 20, 894 (1981). See also Appendix 6.
  • Short: II/6
  • Merck:14,3792
  • Short: II/25B
  • Merck:14,3792 Beilstein:1,338

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H301+H311+H331
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 8 T T,T+
RTECSKJ8225000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P330+P331+P310
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2922
Storage condition Light Sensitive & Hygroscopic <;0 储存温度2-8℃ Light Sensitive <0°C 2-8°C 避光保存
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R34 Causes burns 会导致灼伤
Safety Statements
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S4 Keep away from living quarters 远离生活区；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
Packing GroupII
Hazard Class8/6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,391,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 43 gm/kg/80W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 2(2),246,1983

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,288,1972

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 15 mmol/L
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 25,85,1969

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,367,1974

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 20 uL/disc
REFERENCE :
   AEMIDF Applied and Environmental Microbiology.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.31-    1976-
   Volume(issue)/page/year: 43,177,1982

Restrict 危险品

其他信息

  • 灭火剂:泡沫、二氧化碳、砂土、雾状水
  • 不溶于水，能和乙醇、醚混溶，溶于除石油醚外的大多数有机溶剂。 C/20 mmHg
  • 下游产品:DL-氮杂环丁烷-2-羧酸 --> (S)-(-)-2-羧基环丁胺 --> 2-氨基乙基膦酸 --> 苯基乙烯基砜 --> 溴化乙酰胆碱 --> 甲基丙烯酸 2-(4-苯甲酰基-3-羟基苯氧基)乙酯 --> 2-丙烯酸 2-(4-苯甲酰-3-羟基苯氧基)乙基酯 --> HIDA --> 氯丙那林
  • 不溶于水，能和乙醇、醚混溶，溶于除石油醚外的大多数有机溶剂。
  • 类别:有毒物品
  • 2-溴乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B0590 2-溴乙醇 2-Bromoethanol 25G 213元 2014/06/02 B0590 2-溴乙醇 2-Bromoethanol 500G 1540元 2010/06/21 106921000 2-溴乙醇 2-Bromoethanol 97% 100 ML 1880元
  • MSDS 信息:2-溴乙醇(540-51-2).msds
  • Sigma Aldrich:540-51-2(sigmaaldrich)
  • 蒸气密度:4.3 (vs air)
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类、食品添加剂分开存放
  • 敏感性:Light Sensitive
  • 蒸气压:2.4 mm Hg ( 20 °C)
  • 用途一:用作溶剂、有机化工原料、分析试剂。
  • Alfa Aesar:2-溴乙醇,97% 2-Bromoethanol, 97%(540-51-2)
  • TCI Shanghai:2-溴乙醇 2-Bromoethanol,>;95.0%(GC)(540-51-2)
  • 方法一:由环氧乙烷与溴化氢反应而得：在0-20℃将环氧乙烷通入46%-48%的氢溴酸溶液中，通完后，反应1-2h。在10℃左右用碳酸钠中和氢溴酸，用乙醚提取2-溴乙醇，乙醚溶液用无水硫酸镁干燥过夜，过滤出干燥剂，回收乙醚后得粗品。经减压分馏而得成品。
  • 毒性分级:高毒
  • MOL 文件:540-51-2.mol
  • 外观性质:无色或浅黄色液体，其水溶液具有甜的焦灼味。
  • 可燃性危险特性:明火可燃; 高热放出有毒溴化物气体
  • 图谱信息:2-溴乙醇(540-51-2)红外图谱(IR1) 2-溴乙醇(540-51-2)红外图谱(IR2) 2-溴乙醇(540-51-2)核磁图( 1 HNMR) 2-溴乙醇(540-51-2)质谱(MS) 2-溴乙醇(540-51-2)核磁图( 13 CNMR)
  • Acros Organics:2-溴乙醇 2-Bromoethanol, 97%(540-51-2)
  • 上游原料:干燥剂
  • 急性毒性:腹腔- 小鼠 LDL0: 80 毫克/ 公斤

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Alcohols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Alcohols - Oxygen Compounds
  6. C2 to C6 - Alcohols
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Bromo 溴化物
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BI - BZ - B
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Method Specific - Analytical Standards
  4. ASTM Air Monitoring - Method Specific
  5. ASTM 5578: Analysis of Ethylene Oxide in Air - ASTM Air Monitoring
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Alcohols
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. &#969;-Functional Alkanols, Carboxylic Acids, Amines & Halides