• 原料直供
• 试剂商城
• 直接询价

分类

• {SA} Additional Reagents for Reductive Amination, Borohydrides, Chemical Synthesis, Glycan Labeling, Glycan Labeling and Analysis, Glycobiology, Post-Translational Modification, Proteomics, Reduction, Synthetic Reagents
• {SNA} Borohydrides, Chemical Synthesis, Reduction,

产品应用

• 有机合成用还原剂，醛、酮、肟、烯胺类还原，β-内酰胺还原成β-氨基酸。氨的甲基化。

相关文献及参考

• Tosylhydrazones are reduced to methylenes. The relatively slow reduction of carbonyl compounds enables the tosylhydrazone to be generated in situ: J. Am. Chem. Soc., 93, 1793 (1971); 95, 3662 (1973). For a detailed study of the mechanism of tosylhydrazone reduction, see: J. Org. Chem., 54, 4175 (1989).
• Unlike borohydride reduction of carbonyl compounds which proceeds readily at the natural pH of the solution, reduction by sodium cyanoborohydride is very slow unless the pH is reduced to 3-4. Selective reduction of iminium ions occurs, however, at pH 6-8, leading to the widespread application of the reagent in reductive aminations of carbonyl compounds: J. Am. Chem. Soc., 93, 2897 (1971); Org. Synth. Coll., 6, 499 (1988). For improved methods using combinations with Ti(IV) chloride or isopropoxide, see: Tetrahedron Lett., 31, 5547 (1990); J. Org. Chem., 55, 2552 (1990).
• Oximes are reduced to hydroxylamines, as are O-alkyloximes: Tetrahedron Lett., 2493 (1974). Reduction in the presence of TiCl3 gives primary amines, via the imine: Synth. Commun., 18, 777 (1988).
• Monograph: J. Seyden-Penne, Reductions by the Alumino- and Borohydrides In Organic Synthesis, 2nd ed., Wiley, N.Y. (1997).
• For reviews of the chemistry of sodium cyanoborohydride, see: Synthesis, 135 (1975); Org. Prep. Proced. Int., 11, 201 (1979).

安全信息

其他信息

• 用途一:是一种温和的还原剂，它广泛用于醛、酮的还原，特别是酮的还原胺化作用。
• Sigma Aldrich:25895-60-7(sigmaaldrich)
• TCI Shanghai:氰基硼氢化钠[还原剂] Sodium Cyanoborohydride [Reducing Agent],>;95.0%(T)(25895-60-7)
• Acros Organics:Sodium cyanoborohydride, 1M solution in THF, AcroSeal?(25895-60-7)
• 氰基硼氢化钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 XW258956071 氰基硼氢化钠;氰基三氢化硼钠 10g 135元 2011/08/23 XW258956072 氰基硼氢化钠;氰基三氢化硼钠 50g 498元 2011/08/23 XW258956073 氰基硼氢化钠;氰基三氢化硼钠 250g 1996元
• 用途二:有机合成用还原剂，醛、酮、肟、烯胺类还原，β-内酰胺还原成β-氨基酸。氨的甲基化。
• 存储注意事项:氮气保护;湿度敏感
• 海关编码:28500020
• 敏感性:Moisture Sensitive
• Alfa Aesar:Sodium cyanoborohydride, 95%(25895-60-7)
• Hazard Note:Toxic/Highly Flammable
• MSDS 信息:Sodium cyanoborohydride(25895-60-7).msds
• 下游产品:N-甲基-P-氨基苯甲醚 --> 依那普利 --> N-异丙基-2-（哌嗪-1-基）吡啶-3-胺 --> 6-羧基二氢吲哚 --> 4-氨基嘧啶 --> 2-氨基环己腈 --> 二氢吲哚-6-甲酸乙酯 --> 3-(二甲基氨基)苯硼酸 --> 4-N-叔丁氧羰基-4-N-甲基氨基哌啶 --> 赖诺普利 --> 1-(环丙甲基)哌嗪 --> 1-叔丁氧羰基-4-甲氨基哌啶 --> N-Boc-4-(环丙甲基)哌嗪 --> 4-肼基哌啶-1-羧酸叔丁酯 --> 1-胡椒基哌嗪 --> 6-溴-3,4-二氢-3-硝基-2H-苯并吡喃 --> 1-(3-吡咯烷丙基)哌嗪 --> 4-吡咯烷-1-基-哌啶 --> 4-二甲氨基哌啶 --> 奈替米星
• MOL 文件:25895-60-7.mol
• F:10-21
• 有吸湿性。水中溶解度: 2120 g/L水29°C ）(慢慢分解) ，溶于甲醇，溶于THF(372 g/L at 28°C, 410 g/L at 46°C, 422 g/L at 62°C),溶于二甘醇二甲醚（176 g/L at 25°C），微溶于乙醇，不溶于醚、苯和己烷。在pH3的酸性溶液中稳定，在12N盐酸中能快速水解。