(-)-Riboflavin (-)-核黄素
CAS 83-88-5 MFCD00005022
化学结构图
SMILES: Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@@H](O)[C@@H](O)[C@@H](O)CO)c2cc1C
化学属性
| Mol. Formula | C17H20N4O6 |
|---|---|
| Mol. Weight | 376.36 |
| Melting Point | 290°C |
| TSCA | Yes |
| Solubility | 0.07 G/L (20 ºC) |
| Density | 1.65 |
| Stability | 对光敏感 |
别名和识别编码
| Chemical Name | (-)-Riboflavin |
|---|---|
| Synonym | Riboflavin {hazard_com} 6,7-Dimethyl-9-D-ribitylisoalloxazine 7,8-Dimethyl-10-ribitylisoalloxazine; Lactoflavine; Vitamin B2 Beflavine Hyflavin Isoalloxazine, 7,8-dimethyl-10-D-ribityl- Lactoflavin {} {PubChem} Vitamin G {} {} {PubChem} Vitamin B2 {} {} {} {PubChem} Vitamin B 2 {} {} {} {} {hazard_com} Riboflavinequinone 乳黄素 维生素 B2 维生素 G |
| Beilstein Registry Number | 97825 |
| PubChem Substance ID | 493570 |
| MDL Number | MFCD00005022 |
| CAS Number | 83-88-5 |
| EC Number | 201-507-1 |
| Merck Number | 8200 |
| Chemical Name Translation | (-)-核黄素 |
| Reaxys-RN | 97825 |
| InChIKey | AUNGANRZJHBGPY-MBNYWOFBSA-N |
| Wiswesser Line Notation | T C666 BN DNVMV INJ B1YQYQYQ1Q L1 M1 |
| LabNetwork Molecule ID | LN00238945 |
| InChI | InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1 |
| Canonical SMILES | O[C@H]([C@H](O)[C@H](O)CO)CN1C(C=C(C)C(C)=C2)=C2N=C(C(N3)=O)C1=NC3=O |
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分类
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards P - R
- {SNA} Ana
- {SNA}
- {SNA} Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Armoracia rusticana (Horseradish), Artemisia vulgaris, Berberis sp., Carthamus tinctorius (Safflower oil), Cell Culture, Chamaemelum nobile (Chamomile tea), Cichorium intybus (Chicory), Cimicifuga racemosa, Citrus aurantium (Seville orange), Companion Products and Reagents, Curcuma longa (Turmeric), Elettaria Cardamomum (Cardamom), Ephedra sinica, Fucus vesiculosus,
产品应用
- 酶的辅助因子,丙烯酰胺凝胶聚合作用的黄催化剂。配制组织培养基。生化研究。细菌血清检验中制备钩端螺旋体培养基。
相关文献及参考
- [2]. Zempleni, J., J.R. Galloway, and D.B. McCormick, Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr, 1996. 63(1): p. 54-66.
- [3]. Bertollo, C.M., et al., Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models. Eur J Pharmacol, 2006. 547(1-3): p. 184-91.
- Merck: 14,8200
- Merck: 14,8200 Beilstein: 26,IV,2542
- [1]. Long, Q., et al., Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des, 2010. 75(4): p. 339-47.
- [1]. Long, Q., et al., Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des, 2010. 75(4): p. 339-47.
- [2]. Zempleni, J., J.R. Galloway, and D.B. McCormick, Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr, 1996. 63(1): p. 54-66.
- [3
安全信息
GHS Symbol
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 46A,20,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,75,1942
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 560 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,75,1942
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,75,1942
TYPE OF TEST
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 500 ug/plate
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo
Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei
Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
1949/50- Volume(issue)/page/year: 37,447,1986TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 300 mg/L REFERENCE : GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 100 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 373,1,1997
其他信息
- 稍溶于乙醇、环已醇、苯甲醇、乙酸，微溶于水，不溶于乙醚、氯仿、丙酮和苯。在酸性溶液中稳定，在碱性溶液中或受光照时者易被破坏。微臭，味微苦。
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