3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione 3-异丁基-1-甲基-3,7-二氢-1H-嘌呤-2,6-二酮

CAS 28822-58-4 MFCD00005584

化学结构图

28822-58-4
SMILES: CC(C)Cn1c(=O)n(C)c(=O)c2[nH]cnc21

化学属性

Mol. FormulaC10H14N4O2
Mol. Weight222
Melting Point200-201
TSCANo

别名和识别编码

Chemical Name3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
Synonym 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- IBMX 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮 3-异丁基-1-甲基黄嘌呤 1-甲基-3-异丁基黄嘌呤 3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮 IBMX 1-甲基-3-异丁基黄嘌呤 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
MDL NumberMFCD00005584
Beilstein Registry Number247859
EC Number249-259-3
PubChem Substance ID3758
CAS Number28822-58-4
Chemical Name Translation3-异丁基-1-甲基-3,7-二氢-1H-嘌呤-2,6-二酮
Wiswesser Line NotationT56 BM DN FNVNVJ F1Y1&1 H1
InChIInChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
LabNetwork Molecule IDLN00193678
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分类

  • {SNA} Bioactive Small Molecules, Cell Biology, Core Bioreagents, General Reagents, I, Life Science Reagents for RNAi, Nucleosides and Nucleotides, Research Essentials
  • {SNA} Core Bioreagents, General Reagents, Life Science Reagents for RNAi, Nucleosides and Nucleotides, Research Essentials
  • {SNA} Bioactives/Supplements, Cyclic Nucleotide Metabolism, Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology, Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology Enzymes, G Proteins and Cyclic Nucleotides, General Stem Cell Biology, Phosphodiesterase Inhibitors, Stem Cell Characterization, Stem Cell Isolation, 干细胞生物学, 细胞信

相关文献及参考

  • [2]. Wei Y, et al. Angiotensin II type 2 receptor regulates ROMK-like K+ channel activity in the renal cortical collecting duct during high dietary K+ adaptation. Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F833-43
  • [3]. Hosseini A, et al. Differential metabolic effects of novel cilostamide analogs, methyl carbostiryl derivatives, on mouse and hyperglycemic rat. Iran J Basic Med Sci. 2012 Jul;15(4):916-25.
  • [4]. Crosswhite P, et al. Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension. Hypertension. 2013 Mar;61(3):585-92.
  • [1]. Wu BN, et al. KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. Br J Pharmacol. 2004 Aug;142(7
  • [1]. Wu BN, et al. KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. Br J Pharmacol. 2004 Aug;142(7):1105-14

安全信息

GHS Symbol
RTECSZD8500000
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements
Safety Statements
Precautionary statements 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 25,653,1990

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BIOJAU Biophysical Journal.  (Rockefeller Univ. Press, 1230 York Ave., New
   York, NY 10021) V.1-    1960-  Volume(issue)/page/year: 35,665,1981

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 54,121,1986

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   BIOJAU Biophysical Journal.  (Rockefeller Univ. Press, 1230 York Ave., New
   York, NY 10021) V.1-    1960-  Volume(issue)/page/year: 35,665,1981

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   41,1171,1982

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 1500 umol/L
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 31,155,1985

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleoside Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleosides - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleotide Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleotides - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. I - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Complex Molecules - Chiral Building Blocks
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Stem Cell Biology - Cell Biology
  4. General Stem Cell Biology - Stem Cell Biology
  5. Stem Cell Characterization - General Stem Cell Biology
  6. Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology - Stem Cell Characterization
  7. Enzymes - Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Phosphodiesterase Inhibitors - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nucleic Acid Electrophoresis
  4. Nucleic Acid Gel Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. G Proteins and Cyclic Nucleotides
  5. Cyclic Nucleotide Metabolism
  6. Guanylyl Cyclase Inhibitors
  1. Medical Research Areas
  2. Metabolism
  3. Phosphodiesterase (PDE)  (磷酸二酯酶)

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