2-Amino-4-picoline 2-氨基-4-甲基吡啶

CAS 695-34-1 MFCD00006321

化学结构图

695-34-1
SMILES: Cc1ccnc(N)c1

化学属性

Mol. FormulaC6H8N2
Mol. Weight108
Flash Point118°(244°F)
TSCAYes
Melting Point98.0 to 101.0 deg-C
Boiling Point230 °C(lit.)
Density1.068
SolubilitySoluble in water (41 mg/ml at 20 °C), lower alcohols (slightly), chloroform, ethyl acetate, and DMF.
Stability对湿度敏感

别名和识别编码

Chemical Name2-Amino-4-picoline
CAS Number695-34-1
Alfabeta NameAMINOMETHYLPYRIDINE 24---
MDL NumberMFCD00006321
Synonym Ascensil 4-Picolylamine 2-氨基-4-皮考林;4-甲基-2-吡啶胺;4-甲基-2-氨基吡啶 Aminopicoline 2-Pyridinamine, 4-methyl- alpha-Amino-gamma-picoline 2-Amino-4-methylpyridine NSC 176165 4M2AP Pyridine, 2-amino-4-methyl- 4-甲基-2-氨基吡啶 NSC 1490 2-氨基-4-甲基吡啶 NSC 6972 2-Amino-γ-picoline 4-Methyl-2-pyridylamine 4-Methyl-2-pyridinamine 4-methyl-pyridin-2-ylamine 2-Amino-4-methylpyridine; 4-Methylpyridin-2-amine Methyl-4 amino-2-pyridine 2-Amino-4-picoline 2-氨基-4-皮考林 W 45 Raschig 4-methylpyridin-2-amine 2-amino-4-methyl-pyridine 4-methyl-(2)pyridylamine RA 1226 4-Picoline, 2-amino- VMI 20-4 4-Methyl-2-aminopyridine W 45
EC Number211-780-9
Merck Number466
Beilstein Registry Number22(2)342
PubChem Substance ID87562037
Chemical Name Translation2-氨基-4-甲基吡啶
Reaxys-RN107066
Wiswesser Line NotationT6NJ BZ D1
LabNetwork Molecule IDLN00008181
InChIInChI=1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
  • {SNA} A-AM, Bioactive Small Molecules, Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines, 细胞生物学
  • Heterocycles
  • Miscellaneous Reagents
  • Amines
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • Aromatics
  • {SNA} A-AM, Bioactive Small Molecules, Building Blocks, C6, Cell Biology, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines

产品应用

  • A potent inhibitor of NOS2 (iNOS)

相关文献及参考

  • Merck: 14,466
  • Short: III/20a
  • Short: IV/18B
  • Short: EINECS
  • Merck: 14,466 Beilstein:22(2)342

安全信息

Warnings IRRITANT
RTECSTJ5150000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
UN Number 2811 UN2811
Risk Statements
  • R33 Danger of cumulative effects 有累积作用的危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R25 Toxic if swallowed 吞咽有毒
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
Storage condition 充氩保存 Hygroscopic
Signal word Danger Warning
GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P350
  • P302+P352+P312+P361+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
  • P337+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311
  • H301+H311+H331
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H331 Toxic if inhaled 吸入中毒
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Packing GroupIII
Hazard Codes T
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   53,227S,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,841,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 227,234,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 39 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 26,345,1968

TYPE OF TES

其他信息

  • 2-Amino-4-methylpyridine is a potent inhibitor of NOS2 (iNOS) in vitro.
  • 水中溶解度:41 g/L (20°C),溶于小分子醇,微溶于石油醚。

系列性分类


相关产品推荐