4-Nitroanisole 4-硝基苯甲醚

CAS 100-17-4 MFCD00007327

化学结构图

100-17-4
SMILES: COc1ccc([N+](=O)[O-])cc1

化学属性

Mol. FormulaC7H7NO3
Mol. Weight153
Density1.233 g/mL at 25 °C(lit.)
Flash Point130°(266°F)
TSCAYes
Melting Point51.0 to 55.0 deg-C
Boiling Point274°C(lit.)
Solubility不溶于水，溶于乙醇、乙醚等多数有机溶剂。

别名和识别编码

Chemical Name4-Nitroanisole
Synonym 4-Methoxynitrobenzene p-Nitroanisole 1-methoxy-4-nitro-benzene 4-NITROANISOLE 4-Nitrophenyl methyl ether 4-Nitrophenylmethylether 对硝基苯甲醚 p-Methoxynitrobenzene Methyl 4-nitrophenyl ether 4-METHOXYNITROBENZENE 4-Nitromethoxybenzene p-Nitroanisol P-NITROANISOLE Anisole, 4-nitro 1-Methoxy-4-nitrobenzene 4-硝基苯甲醚 对硝基茴香醚 Benzene,1-methoxy-4-nitro- Benzene, 1-methoxy-4-nitro- 4-Methoxy-1-nitrobenzene p-Methoxynitrobenzene Methoxy-4-nitrobenzol 4-Nitroanisole 1-Methoxy-4-nitrobenzol 4-NITROANISOL OEKANAL, 250 MG Nitroanisole 1-METHOXY-4-NITROBENZENE p-nitro-anisol p-Nitroanisole 1-甲氧基-4-硝基苯 4-nitro-anisole p-Nitrobenzene methyl ether 4-Nitroanisole, 99+% Anisole, p-nitro- Methyl p-nitrophenyl ether p-Nitro-Anisol p-Nitromethoxybenzene 1-methoxy-4-nitrobenzene 4-nitroanisole p-Nitroanisol
Beilstein Registry Number6,230
PubChem Substance ID87573513
CAS Number100-17-4
EC Number202-825-3
MDL NumberMFCD00007327
Reaxys-RN1865361
Merck Number6584
Chemical Name Translation4-硝基苯甲醚
Wiswesser Line NotationWNR DO1
LabNetwork Molecule IDLN00195138
InChIInChI=1S/C7H7NO3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3
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分类

  • {SNA} Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Aromatics, Chemical Class, Chromatography, Environmental Standards, N,
  • {SNA} Additional Standards, Alpha Sort, Analytical Standards, Aromatics, Chemical Class, Chromatography, Environmental Standards, N-O, Nitro Compounds, Organic Pollutant Standards, Volatiles & Semivolatiles, Volatiles/ Semivolatiles, 分析/色谱
  • {SNA} Building Blocks, Chemical Synthesis, Nitro Compounds, Nitrogen Compounds,

产品应用

  • 该品是染料及其他有机合成的中间体，用于制造对氨基苯甲醚、蓝色盐VB等。

相关文献及参考

  • Merck:14,6585
  • Short: II/27B
  • Merck:14,6585 Beilstein:6,230
  • Short: II/14a

安全信息

RTECSBZ8800000
WGK Germany1
Personal Protective Equipment Eyeshields, Gloves dust mask type N95 (US), Eyeshields, Gloves
UN Number 3458 UN 3458 6.1/PG 3 UN3458
Signal word
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P305+P351+P338
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
Safety Statements
Risk Statements
GHS Symbol
Packing GroupIII
Hazard Codes Xn
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : LDLo - Lo

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
   Instituta.  (Leningrad, Russia) V.1-145, 1949-82.  Discontinued.
   Volume(issue)/page/year: 128,14,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Gastrointestinal - other changes
   Liver - fatty liver degeneration
REFERENCE :
   AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.  (Berlin, Ger.)
   V.1-18, 1930-61.  For publisher information, see IAEHDW.
   Volume(issue)/page/year: 17,217,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >16 gm/kg
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.  (Berlin, Ger.)
   V.1-18, 1930-61.  For publisher information, see IAEHDW.
   Volume(issue)/page/year: 17,217,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 698 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   41,216,1977

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 170,11,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 6500 nmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2500 ug/plate
REFERENCE :
   SAIGBL Sangyo Igaku.  Japanese Journal of Industrial Health.  (Nippon Sangyo
   Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
   Japan)  V.1-    1959-  Volume(issue)/page/year: 29,34,1987

Restrict 危险品

其他信息

  • MSDS 信息:4-硝基苯甲醚(100-17-4).msds
  • 图谱信息:4-硝基苯甲醚(100-17-4)红外图谱(IR3) 4-硝基苯甲醚(100-17-4)红外图谱(IR2) 4-硝基苯甲醚(100-17-4)Raman光谱 4-硝基苯甲醚(100-17-4)质谱(MS) 4-硝基苯甲醚(100-17-4)核磁图( 13 CNMR) 4-硝基苯甲醚(100-17-4)红外图谱(IR1)
  • 灭火剂:二氧化碳、泡沫、砂土、雾状水
  • Alfa Aesar:硝基苯甲醚,97% 4-Nitroanisole, 97%(100-17-4)
  • 外观性质:无色结晶。
  • 下游产品:对甲氧基苯胺 --> 6-甲氧基喹啉 --> 6-羟基喹啉
  • TCI Shanghai:4-硝基苯甲醚 4-Nitroanisole,>;98.0%(GC)(100-17-4)
  • 毒性分级:中毒
  • 急性毒性:口服-大鼠 LD50: 2300 毫克/公斤;口服-小鼠 LDL0:300 毫克/公斤
  • 4-硝基苯甲醚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 N0126 4-硝基苯甲醚 4-Nitroanisole 500G 733元 2014/06/02 N0126 4-硝基苯甲醚 4-Nitroanisole 25G 137元 2010/06/21 147020050 4-硝基苯甲醚 4-Nitroanisole 99+% 5 GR 278元
  • 可燃性危险特性:明火可燃; 燃烧释放有毒氮氧化物烟雾
  • MOL 文件:100-17-4.mol
  • 用途二:该品是染料及其他有机合成的中间体，用于制造对氨基苯甲醚、蓝色盐VB等。
  • Sigma Aldrich:100-17-4(sigmaaldrich)
  • 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
  • 方法一:由对硝基氯苯经甲氧基化反应制得。
  • 用途一:用作染料和医药中间体，主要用于生产对氨基苯甲醚、蓝色盐、维生素B等
  • 上游原料:4-硝基氯苯
  • 易溶于醇、醚和沸石油醚，微溶于冷石油醚，不溶于水，水中溶解度:0.468 g/l (20°C)。本品有毒。
  • 类别:有毒物品
  • Acros Organics:4-硝基苯甲醚 4-Nitroanisole, 99+%(100-17-4)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Nitro Compounds 硝基化合物
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Volatiles/ Semivolatiles - Environmental Standards
  6. Alpha Sort - Volatiles/ Semivolatiles
  7. N-O - Alpha Sort
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Isocyanides

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