4-Aminophenol 4-氨基苯酚
CAS 123-30-8 MFCD00007869
化学结构图
SMILES: NC1CCC(O)CC1
化学属性
| Mol. Formula | C6H7NO |
|---|---|
| Mol. Weight | 109 |
| Melting Point | 185-189 |
| Density | 1.21 |
| Flash Point | 195°(383°F) |
| TSCA | Yes |
| Boiling Point | 284 |
| Solubility | 1.5 G/100 ML (20 ºC) |
| Stability | 对光敏感 |
别名和识别编码
| Chemical Name | 4-Aminophenol |
|---|---|
| Synonym | 4-Amino-1-hydroxybenzene 4-Amino-1-hydroxybenzene; 4-Hydroxyaniline 4-Aminophenol 4-Hydroxyanliline 4-氨基-1-羟基苯 4-氨基酚 4-羟基苯胺 ACETAMINOPHEN IMPURITY K AZOL Benzofur P C.I. 76550 C.I. Oxidation Base 6A CITOL Certinal Citol Durafur Brown RB Fouramine P Fourrine 84 Nako Brown R PARA AMINO PHENOL Paranol Pelagol P Base Rodinal Ursol P Ursol P base p-Aminofenol 对氨基酚 4-AMINOPHENOL 对羟基苯胺 對氨基苯酚 羅定那 |
| CAS Number | 123-30-8 |
| PubChem Substance ID | 403 |
| EC Number | 204-616-2 |
| Beilstein Registry Number | 13(3)991 |
| MDL Number | MFCD00007869 |
| Reaxys-RN | 385836 |
| Merck Number | 462 |
| Chemical Name Translation | 4-氨基苯酚 |
| InChIKey | PLIKAWJENQZMHA-UHFFFAOYSA-N |
| Wiswesser Line Notation | ZR DQ |
| LabNetwork Molecule ID | LN00192892 |
| InChI | InChI=1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2 |
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分类
- {SA} A, A-B, AM to AQ, Alpha sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Chemical Class, Chromatography, Environmental Standards, Pesticides & Metabolites
- {SNA} A, A-B, AM to AQ, All alphabetically sorted, Alphabetical Index of Analytical Standards, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Chemical Class, Chromatography, Environmental Standards, Pesticides & Metabolites
- {SNA} Building Blocks,
产品应用
- 检定金，测定铜、铁、镁、钒、亚硝酸盐和氰酸盐，抗氧剂。
相关文献及参考
- Merck: 14,462
- Merck: 14,462 Beilstein:13(3)991
安全信息
GHS Symbol
- H332 Harmful if inhaled 吸入有害
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H302 Harmful if swallowed 吞食有害
- H302+H332
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
- P301+P312
- P301+P312+P330
- P302+P350
- P302+P352+P333+P313+P362+P364
- P304+P340
- P305+P351+P338
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R50/53
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Fr
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease REFERENCE : BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 29-4/1973
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 37 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
Blood - methemoglobinemia-carboxyhemoglobin
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 72,241,1913TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 56200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 5 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,233,1986
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 2 umol/plate REFERENCE : 45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds.,
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 50 mg/kg REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 80,761,1991
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 10 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 26,163,1995
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 100 umol/kg REFERENCE : IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Vo
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 15 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam,
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - hamster DOSE : 150 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,264,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - hamster DOSE : 150 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - body wall REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,264,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - hamster DOSE : 200 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - body wall REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,264,1982
TYPE
其他信息
- 用途四:检定金，测定铜、铁、镁、钒、亚硝酸盐和氰酸盐，抗氧剂。
- {Che
- 上游原料:盐酸 --> 硫酸 --> 发烟硫酸 --> 铁粉 --> 焦亚硫酸钠 --> 4-硝基苯酚 --> 4-硝基苯酚钠 --> 4-硝基儿茶酚 --> 硝基苯酚 --> 苯基羟胺 --> 精细化学品
- 制备方法:对硝基氯苯在氢氧化钠中水解成对硝基苯酚钠，酸化后用铁粉还原而得4-氨基苯酚。 在配碱釜中将氢氧化钠配制成浓度为137～140g/L的溶液，然后将其加入到水解釜内，加入熔融的对硝基氯苯，加热升温到152℃，釜内压力为0.4～0.42MPa(表压)，停止加热，水解反应放出的热量使温度与压力上升到165℃、0.6MPa (表压)，反应3小时，取样分析，使油状馏出物 <0.5%后，水解到终点。冷却至120℃。 将水和98%的浓硫酸加入到第一结晶釜中，然后压入水解物，冷却到50～55℃，加入浓硫酸，使刚果红试纸呈紫色，继续冷却至30℃，抽滤到离心机中进行脱水。 在还原釜内加入上批对氨基苯酚精制过滤后的母液，加热到90℃，加入铁粉和30%的盐酸，在沸腾状态下交替加入铁粉和对硝基苯酚，加料过程视反应情况(如溢锅时)，应补入冷的精制过滤母液。沸腾还原到终点(反应液滴于白色滤纸上，渗圈应无色)。补入一定量的热精制母液，加入氧化镁至反应液中无铁离子。静置30分钟，放出上层清液，下层铁泥用98℃结晶过滤母液打浆，过滤，滤液打入第二结晶釜内。 在第二结晶釜内于4小时内降温到60～65℃，放入第三结晶釜在4小时内继续降温到25℃，维持30分钟，离心过滤。 在精制釜内配成SO2含量为4%～5%的重亚硫酸氢钠溶液，加入结晶过滤的滤饼，搅拌1.5小时，离心过滤，滤饼进行负压气流干燥，得对氨基苯酚成品，精制母液于下批还原时循环使用。
- 下游产品:N-乙酰对氨基酚 --> 对乙氧基苯胺 --> 乙二醇单丁醚 --> 6-羟基喹啉 --> 硫化蓝CV --> 硫化深蓝3R --> 靛酚乙酸酯 --> 洛克沙砷 --> N-(1,3-二甲基丁基)-N'-苯基对苯二胺 --> 硫化红棕B3R --> 硫化红6 --> 弱酸性嫩黄
- Acros Organics:对氨基苯酚 4-Aminophenol, 97.50%(123-30-8)
- 方法一:有铁粉还原法、苯酚亚硝化法、偶合还原法等。1.铁粉还原法 由对硝基酚还原而得。原料消耗定额：硝基苯酚（工业品）1388kg/t、铁粉1778kg/t、30%盐酸200kg/t。2.苯酚亚硝化法 由苯酚经亚硝化、还原、酸析而得。3.偶合还原法 以苯胺为原料，经重氮化、偶合、铁粉还原而得。4.硝基苯催化氢化法 多以铂，钯或二者作催化剂，在10-20%硫酸水溶液中氢化还原为苯基羟胺，随即转位对氨基酚，收率70-80%。在反应系统中加入表面活性剂等对提高产率有一定效果。5.硝基苯电解还原法 日本三井东压精细化学品公司采用在硫酸溶液中电解还原硝基苯，经苯基羟胺转位成对氨基酚，1977年6月该公司在大牟田工厂内建成一套1000吨/年装置。
- 毒性和防护:有毒，对氨基苯酚具有苯胺和苯酚的双重毒性。可经皮肤吸收引起皮炎，能引起高铁
- Sigma Aldrich:123-30-8(sigmaaldrich)
- 图谱信息:4-氨基苯酚(123-30-8)红外图谱(IR1) 4-氨基苯酚(123-30-8)核磁图( 13 CNMR) 4-氨基苯酚(123-30-8)质谱(MS) 4-氨基苯酚(123-30-8)核磁图( 1 HNMR)
- 外观性质:白色至灰褐色结晶。
- 可燃性危险特性:明
- 4-氨基苯酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80005425 4-氨基酚;对氨基酚;4-羟基苯胺;4-氨基-1-羟基苯 50g 22元 2011/08/23 80005426 4-氨基酚;对氨基酚;4-羟基苯胺;4-氨基-1-羟基苯 100g 44.5元 2011/08/23 80005427 4-氨基酚;对氨基酚;4-羟基苯胺;4-氨基-1-羟基苯 250g 100元
- 常规方法:采用铁桶、纸桶或纤维板桶内衬塑料袋包装，每桶净重35kg、40kg或50kg。贮存时要避光，防止受热、受潮。按有毒危险品规定贮运。
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