2-Amino-2-Methylpropane 叔丁胺

CAS 75-64-9 MFCD00008050

化学结构图

75-64-9
SMILES: CC(C)(C)N

化学属性

Mol. FormulaC4H11N
Mol. Weight73.14
Density0.696
Refractive index1.3750 to 1.3790
Autoignition Point716 °F
Vapor Density2.5 (vs air)
Boiling Point46
Vapor Pressure5.7 psi ( 20 °C)
Melting Point-67
Flash Point-38 °C
TSCAYes
SolubilityMISCIBLE
Danger-Level甲类

别名和识别编码

Chemical Name2-Amino-2-Methylpropane
Synonym tert-Butylamine {LY} tert-Butylamine {} {LY} tert-Butylamine {} {} {LY} tert-Butylamine {} {} {} {LY} tert-Butylamine {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butylamine {} {} {} {} {} {
MDL NumberMFCD00008050
CAS Number75-64-9
EC Number200-888-1
Beilstein Registry Number605267
PubChem Substance ID87563710
Merck Number1545
Chemical Name Translation叔丁胺
Reaxys-RN605267
Wiswesser Line NotationZX1&1&1
LabNetwork Molecule IDLN00195780
InChIInChI=1S/C4H11N/c1-4(2,3)5/h5H2,1-3H3
Canonical SMILESCC(N)(C)C
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分类

  • {SNA} Amines, Building Blocks, C2 to C5, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
  • {Chemicalbook} 农药中间体: 杀螨剂中间体
  • {uni_hamburg} no charge; 1fragment

产品应用

  • 有机合成原料,用以合成医药、橡胶硫化促进剂、杀虫剂、杀菌剂和染料着色剂,也可用作溶剂。

相关文献及参考

  • Short: II/25C
  • Short: III/20a
  • Merck: 14,1545 Beilstein:4,173
  • Merck: 14,1545

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20 Harmful by inhalation 吸入有害
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R25 Toxic if swallowed 吞咽有毒
  • R35 Causes severe burns 会导致严重灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R52/53
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331+P310
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US)
RTECSEO3330000
Packing GroupII
UN Number 3286
Storage condition RT, stored under argon {LY} RT, stored under argon {} {LY} RT, stored under argon {} {} {LY} RT, stored under argon {} {} {} {LY} RT, stored under argon {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored u
Hazard Codes 3 F,C F;T
Hazard Class3/6.1, 8
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Lungs, Thorax, or Respiration - pulmonary emboli
   Liver - other changes
REFERENCE :
   NTIS** National Technical Information Service

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 50(12),70,1985

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Gastrointestinal - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0570521

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 378 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 50(12),70,1985

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Restrict 危险品

其他信息

  • 蒸气压:5.7 psi ( 20 °C)
  • 下游产品:4-乙酰氧基氮杂环丁酮 --> 2-氨基喹啉 --> N-叔丁基-#-苯基硝酮 --> 烟嘧磺隆 --> 2-氨基-6-溴苯酚 --> 安非他酮 --> 4-(氨基磺酰基)苯硼酸 --> N-叔丁基-2-苯并噻唑次磺酰胺 --> 硫酸叔丁宁按 --> 爱普列特 --> 利福平 --> 克仑特罗 --> 异氰酸叔丁酯 --> 特丁净 --> N-叔丁基苄胺 --> 苯甲丁氮酮 --> 布诺洛尔
  • Sigma Aldrich:75-64-9(sigmaaldrich)
  • 方法一:叔丁胺是由叔丁醇经缩合、水解而得。 (1)缩合 叔丁醇与尿素缩合得叔丁脲。 (CH 3 ) 3 COH[NH 2 CONH 2 ]→(CH 3 ) 3 —NHCONH 2 在干燥的反应锅内加入硫酸,搅拌冷却,在15~25℃缓缓加入尿素,维持20~25℃再加入叔丁醇,加毕,搅拌0.5h,放置过夜。将反应物放入冰水中,加20%氢氧化钠溶液中和至pH=3~4,冷至15~17℃过滤,用冰水洗涤,滤饼加水煮沸溶解,趁热过滤,滤液冷至0~5℃析出结晶,过滤干燥得叔丁脲。 (2)水解 (CH 3 ) 3 C—N
  • {Chem
  • {
  • 方法二:1.以叔丁醇和尿素为原料在硫酸中缩合、水解,得叔丁基脲,再用40%的氢氧化钠中和,经水洗、滤干,加液碱、乙二醇混合后加热,收集40-60℃蒸馏物,然后加固碱干燥,常压分馏,切取44-47℃馏分得叔丁胺成品。原料消耗定额:叔丁醇(98%)2400kg/t、尿素2400kg/t、浓硫酸(98%)460kg/t。2.异丁烯-氢氰酸法制叔丁胺首先将异丁烯与氢氰酸反应,生成叔丁胺硫酸盐,然后与氨中和,制得叔丁胺,同时副产硫酸氢铵3.根据有关资料报道,叔丁胺除上述制法外,还有
  • 职业标准:TWA 15 毫克/ 立方米; STEL 75 毫克/ 立方米
  • 叔丁胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80024327 叔丁胺¤ 250ml 62.8元 2011/04/16 B0709 叔丁胺 tert-Butylamine 500ML 350元 2011/04/16 B0709 叔丁胺 tert-Butylamine 25ML 155元
  • 用途一:橡胶工业用于制造橡胶促进剂,制药工业用于制造利福平。农药工业用于制造杀虫剂、杀菌剂。染料工业用于制造染料着色剂。有机工业用作有机合成中间体。分析化学中用作化学试剂。
  • 图谱信息:叔丁胺(75-64-9)质谱(MS) 叔丁胺(75-64-9)核磁图( 1 HNMR) 叔丁胺(75-64-9)核磁图( 13 CNM
  • 方法一:叔丁胺是由叔丁醇经缩合、水解而得。 (1)缩合 叔丁醇与尿素缩合得叔丁脲。 (CH 3 ) 3 COH[NH 2 CONH 2 ]→(CH 3 ) 3 —NHCONH 2 在干燥的反应锅内加入硫酸,搅拌冷却,在15~25℃缓缓加入尿素,维持20~25℃再加入叔丁醇,加毕,搅拌0.5h,放置过夜。将反应物放入冰水中,加20%氢氧化钠溶液中和至pH=3~4,冷至15~17℃过滤,用冰水洗涤,滤饼加水煮沸溶解,趁热过滤,滤液冷至0~5℃析出结晶,过滤干燥得叔丁脲。 (2)水解 (CH 3 ) 3 C—NHCONH 2 [NaOH]→[H 2 O](CH 3 ) 3 C—NH 2 将氢氧化钠溶液、叔丁脲、乙二醇加入反应锅,加热回流4h。将反应物进行蒸馏,收集40~90℃馏分,得粗叔丁胺。加少量固体氢氧化钠干燥过夜,粗馏,收集43~52℃馏分,得精制的叔丁胺。 美国罗姆-哈斯公司采用异丁烯为原料,与
  • 爆炸物危险特性:与空气混合可爆; 与2,2-二溴-1,3-二甲基环丙酸反应异常激烈
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生有毒氮氧化物烟雾
  • 急性毒性:口服- 大鼠 LD50: 78 毫克/公斤; 口服-小鼠 LD50: 900 毫克/公斤
  • 用途二:用于合成橡胶促进剂、农药、医药、表面活性剂等
  • MOL 文件:75-64-9.mol
  • 灭火剂:干粉、二氧化碳、泡沫
  • 方法一:叔丁胺是由叔

系列性分类