α-Methylbenzylamine α-甲基苄胺

CAS 618-36-0 MFCD00008069

化学结构图

618-36-0
SMILES: CC(N)c1ccccc1

化学属性

Mol. FormulaC8H11N
Mol. Weight121.18
Density0.94
Refractive indexn20/D 1.526(lit.)
Flash Point70°C
TSCAYes
Boiling Point185°C at 760 mmHg
Melting Point-65 °C
Solubility4.2 G/100 ML (20 ºC)
Appearance 无色液体。熔点-65℃，沸点188℃，80-81℃（2.4kPa），相对密度0.9395（15/4℃），折射率1.5253，闪点79℃，能与醇、醚混溶，溶于水。具强碱性，能吸收空气中的二氧化碳。有芳香气味。
Stability对空气敏感,易吸潮

别名和识别编码

Chemical Nameα-Methylbenzylamine
Synonym 1-Phenylethanamine {LY} 1-Phenylethanamine {} {LY} 1-Phenylethanamine {} {} {LY} 1-Phenylethanamine {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Phenylethanamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Phenylethanamine
CAS Number618-36-0
EC Number210-545-8
Beilstein Registry Number636127
MDL NumberMFCD00008069
Merck Number6026
PubChem Substance ID7408
Reaxys-RN636127
Chemical Name Translationα-甲基苄胺
LabNetwork Molecule IDLN00173406
InChIInChI=1S/C8H11N/c1-7(9)8-5-3-2-4-6-8/h2-7H,9H2,1H3
Canonical SMILESCC(N)C1=CC=CC=C1
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分类

  • {SNA} Amines, Building Blocks, C8, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; racemate; 1fragment

相关文献及参考

  • Short: IV/13A1 Title: Vapor-Liquid Equilibrium in Mixtures and Solutions. Binary Liquid Systems of Nonelectrolytes. Part 1 Author: Wichterle, I.; Linek, J.; Wagner, Z.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V. Editor: Kehiaian, H.V. Source: Landolt-Börnstein, New Series Volume: IV/13A1 Year: 2007 Keyword: Activity coefficients; Excess Gibbs energy; Mixtures; Nonelectrolytes; Solutions; Vapor-liquid equilibria ISBN: 978-3-540-49314-3 (Print) ISBN: 978-3-540-49315-0 (Online) Internet Resource: doi: 10.1007/978-3-540-49315-0 RefComment: X, 571 p. 820 illus. With CD-ROM., Hardcover RefComment: Written for: Scientists and engineers in the field of physical chemistry, organic chemistry, inorganic chemistry, biochemistry, applied chemistry Abstract: This volume is a compilation of vapor–liquid equilibrium data on subcritical binary single-phase or two-phase liquid–liquid systems. All the components are well-defined pure substances, which are organic or inorganic nonelectrolytes, including low-melting ionic liquids and water. The present database contains numerical data for 3316 systems. The book reproduces in tables and graphs the numerical values for only 802 binary mixtures, chosen to be representative of all the compound classes and property types. The full set of data is given on the CD–ROM accompanying the book. Most data files contain experimental data compiled from the original literature published from 1929 to mid 2006. The CD-ROM displays all these data in PDF format and in fully documented computer readable standard electronic files (SELF and ELDATA). The ELBT-program allows the fast search of data according to property type, chemical system, author(s), source and year of publication. It also includes the bibliographical database of ELDATA, EVLM’2006, giving 13471 references from 1888 through mid 2006 to experimental vapor–liquid equilibrium in mixtures and solution.
  • Short: IV/18B Title: Viscosity of Pure Organic Li

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P330+P331
  • P302+P352
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSDP5775000
Packing GroupII
UN Number 2735 2922
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light Air Sensitive {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from
Hazard Codes 8 C
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H318 Causes serious eye damage 严重伤害眼睛
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Class8/6.1

其他信息

  • 方法一:以苯乙酮为原料，与甲酸铵反应生成1-苯基乙基甲酰胺，经盐酸水解得到1-苯基乙胺盐酸盐，然后用氢氧化钠溶液碱化得到外消旋型1-苯基乙胺。另一种制法是苯乙酮和氨在阮内镍催化下高压加氢还原，制得DL-1-苯基乙胺。催化反应的温度为150℃，压力为34.5-24MPa。
  • 毒性分级:中毒
  • 用途一:用作医药中间体
  • TCI Shanghai:DL-1苯基乙胺 DL-1-Phenylethylamine,>;98.0%(GC)(618-36-0)
  • 灭火剂:干粉、泡沫、砂土, 二氧化碳, 雾状水
  • 下游产品:1R,3R-二溴菊酸 --> 1-(溴甲基)异喹啉 氢溴酸 --> S-烯丙醇酮 --> 1R,3R-反式菊酸 --> 1R-顺式菊酸 --> S-2-(4-氯苯基)-3-甲基丁酸
  • Sigma Aldrich:618-36-0(sigmaaldrich)
  • 上游原料:氨 --> 乙酰苯 --> 甲酸铵
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物烟雾
  • 类别:有毒物品
  • 用途一:用作医药中间体、拆分剂
  • 用途二:用作医药、染料、香料、乳化剂等的中间体。
  • Acros Organics:DL-alpha-甲基苄胺/DL-alpha-苯乙胺 DL-alpha-Methylbenzylamine, 99%(618-36-0)
  • 急性毒性:口服-大鼠LD50: 940 毫克/公斤
  • 储运特性:库房通风低温干燥
  • MOL 文件:98-84-0.mol
  • 海关编码:29214980
  • alpha-甲基苄胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0165 DL-1-苯乙胺 DL-1-Phenylethylamine 25ML 152元 2014/06/02 M0165 DL-1-苯乙胺 DL-1-Phenylethylamine 500ML 684元 2010/06/21 126395000 alpha-甲基苄胺 DL-alpha-Methylbenzylamine 99% 500 GR 973元
  • 用途二:磷霉素的中间体。是一种拆分剂、手性合成的中间体。
  • MOL 文件:618-36-0.mol
  • 下游产品:DL-氮杂环丁烷-2-羧酸 --> S-1-苯乙胺 --> 1-(1-苯基乙基)哌嗪
  • 上游原料:乙酰苯 --> 甲酸铵 --> R(+)-alpha-甲基苄胺
  • Alfa Aesar:(±)-1-苯乙胺,98+% (+/-)-1-Phenylethylamine, 98+%(618-36-0)
  • 敏感性:Air Sensitive
  • F:10-23
  • 刺激数据:皮肤-兔子10毫克/24小时 重度; 眼睛-兔子 0.25 毫克 重度
  • Sigma Aldrich:98-84-0(sigmaaldrich)
  • 方法一:用苯乙酮与甲酸铵反应或用苯乙酮在液氨中还原制取。
  • MSDS 信息:DL-alpha-Methylbenzylamine(618-36-0).msds

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. C12 - Amines
  1. C8 - Amines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amines 胺
  6. C7