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• {SNA} Bioactive Small Molecules, Building Blocks, Cell Biology, Chemical Synthesis, D-DIF, Hordeum vulgare (Barley), Nitrogen Compounds, Nutrition Research, Organic Building Blocks, Phytochemicals by Plant (Food/Spice/Herb), Polyamines
• {uni_hamburg} no charge; 1fragment
• Bioactive Small Molecules, Building Blocks, Cell Biology,
• {SNA} Building Blocks,
• {SNA} Building Blocks, Chemical Synthesis, Hordeum vulgare (Barley), Nitrogen Compounds, Organic Building Blocks, Phytochemicals by Plant (Food/Spice/Herb), Polyamines, 细胞生物学, 营养研究
• {SNA} Bioactive Small Molecules, Building Blocks, Chemical Synthesis,

产品应用

• 溶剂。净化剂。有机合成中间体，KAPA制备的起始材料，分子末端异构化用强碱基。

相关文献及参考

• Short: III/31a
• The potassium derivative (KAPA) is a very strong base, valuable for its ability to cause the migration of acetylenic unsaturation to the terminal positions of alkynes (known as the "zip" reaction). In the presence of excess amine, reaction occurs within seconds; the driving force is the formation of a stable acetylide anion: J. Am. Chem. Soc., 97, 891 (1975). For example, with acetylenic carbinols: J. Chem. Soc., Chem. Commun., 959 (1976); Tetrahedron Lett., 2565 (1976); Can. J. Chem., 62, 1333 (1984). For a further example (2- to 9-decynol), using a combination of Potassium tert-butoxide, A13947, and Li 3-aminopropanamide, see: Org. Synth. Coll., 8, 146 (1993). This technique avoids the use of KH. For the use of KAPA for the isomerization of ß-pinene to the thermodynamically-more stable ɑ-pinene, see: Org. Synth. Coll., 8, 553 (1993).
• For procedures for the generation of Na or K 3-amino-propylamides from the metals by ultrasound irradiation or in the presence of Fe(NO3)3, see: J. Org. Chem., 49, 2494 (1984).
• Beilstein:4,261

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 296 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 264 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 28,237,1983

其他信息

• 上游原料:乙醇溶液 --> 1,2-二溴丙烷
• 图谱信息:1,3-丙二胺(109-76-2)Raman光谱 1,3-丙二胺(109-76-2)核磁图( 13 CNMR) 1,3-丙二胺(109-76-2)质谱(MS) 1,3-丙二胺(109-76-2)核磁图( 1 HNMR) 1,3-丙二胺(109-76-2)红外图谱(IR1)
• 1,3-丙二胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 AD2360201 1,3-丙二胺;1,3-二氨基丙烷; 三亚甲二胺; 1,3-亚丙基二胺 25g 325元 2011/08/23 AD2360202 1,3-丙二胺;1,3-二氨基丙烷; 三亚甲二胺; 1,3-亚丙基二胺 500g 865元 2011/08/23 K3325001 1.3-丙二胺 100ml 290元
• 灭火剂:泡沫、干粉、二氧化碳、砂土
• 用途一:用于医药、农药的合成，是造纸、纺织、皮革工业的辅助原料，还用于环氧树脂固化剂的合成
• F:34
• 下游产品:高哌嗪 --> 环庚草醚 --> N-叔丁氧羰基-1,2-乙二胺 --> N-叔丁氧羰基-1,3-丙二胺 --> 椰油酰胺基丙基甜菜碱 --> N,N-二羟乙基,N-对十八烷基苯磺酰胺丙基铵基丙磺酸盐
• 可燃性危险特性:遇明火、高温、强氧化剂可燃; 受热分解出有毒氧化氮气体
• Acros Organics:1,3-二氨基丙烷 1,3-Diaminopropane, 99%(109-76-2)
• MSDS 信息:1,3-丙二胺(109-76-2).msds
• 有氨的气味。有吸湿性。 易吸收二氧化碳。能与水、乙醇、乙醚、氯仿、苯混溶，溶于甲醇。
• 急性毒性:口服- 大鼠 LD50: 350 毫克/ 公斤; 腹注- 小鼠 LD50: 296 毫克/ 公斤
• 类别:可燃物品
• 刺激数据:皮肤- 兔子 50 毫克 重度; 眼- 兔子 1 毫克 重度
• TCI Shanghai:1,3-丙二胺 1,3-Diaminopropane,>;98.0%(GC)(109-76-2)
• 用途三:溶剂。净化剂。有机合成中间体，KAPA制备的起始材料，分子末端异构化用强碱基。
• Alfa Aesar:1，3-二氨基丙烷,98% 1,3-Diaminopropane, 98%(109-76-2)
• MOL 文件:109-76-2.mol
• Sigma Aldrich:109-76-2(sigmaaldrich)
• 方法一:将1份二溴丙烷与8-9份在0℃饱和氨和乙醇溶液混溶，放置3-4d。蒸干，剩余物加碱液后蒸馏。馏出物用盐酸中和。蒸浓，冷却，将浓缩液干燥使盐酸盐结晶析出。用碱分解盐酸盐，蒸馏出1,3-丙二胺。
• 毒性分级:高毒
• 敏感性:Air Sensitive
• 用途二:用作净化剂、有机合成中间体。
• 外观性质:水白色液体，有氨的气味。
• 储运特性:包装完整、轻装轻卸; 库房通风、远离明火、高温、与氧化剂、酸分开存放
• 蒸气压:<;8 mm Hg ( 20 °C)
• 海关编码:29212900