N,N'-Methylenebisacrylamide N,N'-亚甲基双丙烯酰胺

CAS 110-26-9 MFCD00008625

化学结构图

110-26-9
SMILES: C=CC(=O)NCNC(=O)C=C

化学属性

Mol. FormulaC7H10N2O2
Mol. Weight154.17
Melting Point>300 °C
Density1.235
TSCAYes
Vapor Density5.31 (vs air)
Solubility0.01-0.1 G/100 ML AT 18 ºC
Stability对光和空气敏感
Appearance powder 是一种白色晶体粉末，无味，吸湿性极小。遇高温或强光则自交联，微溶于水、乙醇。密度 1.235 ,熔点 185°C ,水溶性 0.01-0.1 g/100 mL at 18°C
Boiling Point277.52 °C at 760 mmHg

别名和识别编码

Chemical NameN,N'-Methylenebisacrylamide
Synonym N,N'-Methylenebisacrylamide {LY} N,N'-Methylenebisacrylamide {} {LY} N,N'-Methylenebisacrylamide {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {
CAS Number110-26-9
PubChem Substance ID354333741
EC Number203-750-9
Beilstein Registry Number1706297
MDL NumberMFCD00008625
Reaxys-RN1706297
Chemical Name TranslationN,N'-亚甲基双丙烯酰胺
Wiswesser Line Notation1U1VM1MV1U1
LabNetwork Molecule IDLN00194689
InChIInChI=1S/C7H10N2O2/c1-3-6(10)8-5-9-7(11)4-2/h3-4H,1-2,5H2,(H,8,10)(H,9,11)
Canonical SMILESC=CC(NCNC(C=C)=O)=O
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分类

  • {SNA} Gel Cross-Linkers, SDS-PAGE, 分子生物学, 蛋白电泳, 蛋白质组学
  • {SNA} Protein Sequencing,
  • {
  • {SNA} Acrylamide, Acrylamides,
  • {SNA} Acrylamides, Core Bioreagents, Electrophoresis of Glycans, Gel Cross-Linkers, Glycan Labeling and Analysis, Glycobiology, Life Science Reagents for DNA/RNA E

产品应用

  • 用于和丙烯酰胺混合制备聚丙烯酰胺凝胶,用在蛋白质和核酸电泳中。N,N′-Methylenebis(acrylamide)

相关文献及参考

  • Crosslinking agent for the synthesis of polyacrylamide gels.
  • Crosslinking agent for the synthesis of polyacrylamide gels.
  • 2. D. Rickwood, B.D. Hames Gel Electrophoresis of Nucleic Acids: A Practical Approach Oxford , (1983)

安全信息

GHS Symbol
WGK Germany2
Hazard Codes Xn
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H332 Harmful if inhaled 吸入有害
Personal Protective Equipment Eyeshields, Faceshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) dust mask type N95 (US), Eyeshields, Faceshields, Gloves Eyeshields, Faceshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Faceshields, Gloves
RTECSAS3678000
Signal word Warning
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number 2811 UN 2811
Packing GroupIII
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitro
Hazard Class6.1(b) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - tremor
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,111,1990

TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >41 ppm/6H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,111,1990

TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >41 ppm/6H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,1

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 600 ppm
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   23,208,1994

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 229,161,1990

TYPE OF TEST            : Heritable translocation test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 450 mg/kg/5D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 229,161,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 225 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 229,161,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3208 mg/kg
SEX/DURATION            : male 16 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   47,179,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 360 mg/kg
SEX/DURATION            : female 6-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB92-177781

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

其他信息

  • 用途三:用作分离氨基酸的重要材料及光敏尼龙或光敏塑料的重要原料
  • Acros Organics:N,N'-亚甲基双丙烯酰胺 N,N'-Methylenebisacrylamide, extra pure, 96%(110-26-9)
  • 图谱信息:N,N'-亚甲基双丙烯酰胺(110-26-9)红外图谱(IR2) N,N'-亚甲基双丙烯酰胺(110-26-9)红外图谱(IR1) N,N'-亚甲基双丙烯酰胺(110-26-9)Raman光谱 N,N'-亚甲基双丙烯酰胺(110-26-9)质谱(MS)
  • 蒸气密度:5.31 (vs air)
  • TCI Shanghai:N,N'-亚甲基双丙烯酰胺[用于电泳] N,N'-Methylenebisacrylamide [for Electrophoresis],>;98.0%(T)(110-26-9)
  • 上游原料:丙烯酰胺
  • 用途四:生物高分子化合物(蛋白质、多肽、核酸)的分离。制备聚丙烯酰胺凝胶的交联剂。聚丙烯酰胺凝胶技术和临床检验。
  • Alfa Aesar:N,N'-甲烯基双丙烯酰胺,99+% N,N'-Methylenebisacrylamide, 99+%(110-26-9)
  • 海关编码:29241900
  • MOL 文件:110-26-9.mol
  • Sigma Aldrich:110-26-9(sigmaaldrich)
  • N,N'-亚甲基双丙烯酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30117826 N，N-亚甲基双(丙烯酰胺) 100g 92元 2011/08/23 k6667001 N.N-亚甲基双（丙烯酰胺） 100g 430元 2011/08/23 S14607203 N,N’-亚甲基双丙烯酰胺 100g 472元
  • MSDS 信息:N,N'-Methylenebis(2-propenamide)(110-26-9).msds
  • F:8
  • 用途一:用作光敏尼龙和光敏塑料原料、建筑灌浆材料，也用于照相、印刷、制版等
  • 用途二:可在油田钻井作业中和建筑灌浆作业中用作堵水剂，亦可在丙烯酸树脂和粘合剂合成中用作交联剂
  • 下游产品:微波法合成的阳离子高吸水性树脂 --> 微波法合成的两性高吸水性树脂
  • 无气味，吸湿性极小。对光敏感。遇高温或强光则自交联，微溶于水，溶于乙醇。水中溶解度：3 g/L (25°C)，水溶液可因水解而形成丙烯酸和氨。中等毒，半数致死量(大鼠，经口)390mg/kg。有刺激性。

系列性分类

  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Life Science Reagents for DNA/RNA Electrophoresis - Core Bioreagents
  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Life Science Reagents for Western Blotting - Core Bioreagents
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Nucleic Acid Electrophoresis - Molecular Biology
  4. Acrylamide - Nucleic Acid Electrophoresis
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Nucleic Acid Electrophoresis - Molecular Biology
  4. Acrylamide - Nucleic Acid Electrophoresis
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Electrophoresis - Proteomics
  4. SDS-PAGE - Protein Electrophoresis
  5. Gel Cross-Linkers - SDS-PAGE
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Structural Analysis - Proteomics
  4. Protein Sequencing - Protein Structural Analysis
  5. Reagents for Protein Sequencing - Protein Sequencing
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Chelators
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Glycobiology
  4. Glycan Labeling and Analysis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Functional Group Reactive Labels
  5. Functional Group Reactive Labels for Spectroscopy
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteomics
  4. Protein Structural Analysis
  5. Protein Sequencing
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Molecular Biology
  4. Protein Electrophoresis
  5. SDS-PAGE
  6. Gel Casting Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteomics
  4. Post-Translational Modification
  5. Glycobiology
  6. Glycan Component Classes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteomics
  4. Protein Electrophoresis
  5. SDS-PAGE
  6. Gel Casting Reagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Plant Biotechnology
  4. Plant Proteomics
  5. Protein Electrophoresis
  6. SDS-PAGE
  7. Gel Casting Reagents