• 原料直供
• 试剂商城
• 直接询价

分类

• ACS and Reagent Grade Solvents, Acetals/Ketals/Ortho Esters, Amber Glass Bottles, Building Blocks, Carbon Steel Cans with NPT Threads, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Reagent, Reagent Grade Solvents, Semi-Bulk Solvents, Solvent Bottles, Solvent Packaging Options, Solvent by Application, Solvents
• {SNA} Anhydrous Solvents, Solvent Bottles, Solvent Packaging Options, Solvent by Application, Solvents, Sure/Seal Bottles
• {Chemicalbook} 农药中间体: 杀螨剂中间体
• {SNA} Acetals/Ketals/Ortho Esters, Building Blocks, Chemical Synthesis, Organic Building Blocks,

产品应用

• A reagent useful for acetylization and imidic ester formation.

相关文献及参考

• Short: III/35E
• In the presence of BF3 etherate, is a source of the diethoxycarbenium ion: Synth. Commun., 19, 2307 (1989), a selective alkylating agent and a useful intermediate for the diethoxymethylenation of ketones, to give protected ß-ketoaldehydes: J. Org. Chem., 46, 2557 (1981). For a similar reaction with enamines to give the same products, see: Chem. Lett., 1307 (1982); Bull. Chem. Soc. Jpn., 57, 1876 (1984).
• Orthoformates have also found use in the electrophilic formylation of activated aromatic species, e.g.: phenols (in the presence of AlCl3): Chem. Ber., 96, 308 (1963); pyrrole derivatives (with TFA): Austral. J. Chem., 25, 1979 (1972).
• Short: III/38B
• Acid-catalyzed reaction with an arylamine gives the N-ethoxymethylene derivative (imidic ester); see, e.g.: Org. Synth. Coll., 4, 464 (1963); reduction (NaBH4) gives the monomethyl amine: Synthesis, 55 (1974).
• For further reactions of alkyl orthoformates, see Trimethyl­ orthoformate, A13760.
• Merck: 14,6884 Beilstein:2,20
• Merck: 14,6884
• Due to their intrinsic dehydrating property, orthoformates are convenient reagents for acetalization of carbonyl compounds, under acid catalysis, e.g. tosic acid: J. Am. Chem. Soc., 60, 1905 (1938); J. Org. Chem., 20, 1695 (1955), or acidic ion-exchange resin: Synthesis, 348 (1974). Selective catalysis with NBS has been found to give high yields of acetals under almost neutral conditions: Synlett, 1456 (1999).

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >10 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 17,917,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7060 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/8H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

其他信息

• 有类
• 用途四:医药原料，是抗疟药物氯喹和喹哌等的合成原料。也用于制高聚物、照相药品、感光材料、防光晕染料、花青染料及合成农药等。
• Triethyl orthoformate is a useful organic synthesis reagent for acetylization, imidic ester formation, and activated aromatic species formation.
• 毒性分级:中毒
• Acros Organics:原甲酸三乙酯/三乙氧基甲烷 Triethyl o
• 用途三:原甲酸三乙酯是杀螨剂双甲脒和除草剂吡嘧磺隆的中间体，也可用于制抗疟药氯喹、喹哌等药品。
• 储运特性:库房通风低温干燥; 与氧化剂分开存放
• 类别:较易燃液体
• 原甲酸三乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80063427 原甲酸乙酯 250ml 56.2元 2011/04/16 O0066 原甲酸三乙酯 Triethyl Orthoformate 25ML 167元 2011/04/16 O0066 原甲酸三乙酯 Triethyl Orthoformate 500ML 354元
• 下游产品:2-(3-吡啶基)-1,3,4-恶二唑 --> 1-环己基尿嘧啶 --> 5-氨基-4-异噁唑羧酸甲酯 --> 4-乙酰基苯硼酸 --> 2-乙巯基-5-羟甲基-6-氨基嘧啶 --> 1-环己基-1,2,3,4-四氢-2,4-二氧嘧啶-5-腈 --> 5-甲醛基呋喃-2-硼酸 --> 艾司唑仑 --> 2,4-氨基嘧啶-5-羧酸 --> 4-甲基嘧啶 --> 3,5-二氰基-3-氨基吡啶 --> 4-羟基-6-三氟甲基喹啉-3-甲酸乙酯 --> 4,6-二羟基烟酸乙酯 --> 4-苯基-2-羟基嘧啶-5-羧酸乙酯 --> 2,4-二氨基嘧啶-5-腈 --> 2-乙硫基-4-氨基嘧啶-5-羧酸乙酯 --> 4-甲基-2-羟基嘧啶-5-羧酸乙酯 --> 4-氯-7-三氟甲基喹啉 --> 4-甲基-2-羟基嘧啶-5-羧酸 --> 乙酸二乙氧基甲酯 --> 3-氨基吡唑-4-甲酸 --> 2-(乙硫基)-4-羟基嘧啶-5-乙酸乙酯 --> 5-氨基-4-乙氧羰基-1-苯基吡唑 --> 4-苯基-2-羟基嘧啶-5-羧酸 --> 5-氨基-1-苯基吡唑-4-腈 --> 3-三氟甲基吡唑-4-羧酸乙酯 --> 5-尿嘧啶甲酸乙酯 --> N-FMOC-L-甘氨酸 --> 4-氨基-2-(甲基硫代)嘧啶-5-腈 --> 2-氨基-6-氯-3,5-二氰基吡啶 --> 4,5-二氰基咪唑 --> 乙氧甲叉 --> 氯甲基三乙氧基硅烷
• 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
• Sigma Aldrich:122-51-0(sigmaaldrich)
• {Ch
• 方法一:其制备方法是在反应釜内加入氯仿并搅拌，加热至55℃，滴加乙醇钠乙醇溶液，反应温度控制在60～65℃，加毕逐渐升温至70℃，保温1h，反应结束时pH<;8，滤去氯化钠，滤液分馏得粗品，再进行精馏得成品。3C 2 H 5 ONa+CHCl 3 →CH(OC 2 H 5 ) 3 +3NaCl
• 用途一
• Alfa Aesar:原甲酸三乙酯,98% Triethyl orthoformate, 98%(122-51-0)
• 用途五:医药原料，是抗疟药物氯喹和喹哌等的合成原料。也用于制高聚物；照相药品；感光材料；防光晕染料；花青染料及合成农药等。
• 可燃性危险特性:
• 图谱信
• 方法二:1.乙醇钠法以乙醇钠和氯仿为原料，在60-65℃下反应，生成原甲酸三乙酯粗制品，再经分馏精制
• 急性毒性:吸入- 大鼠 LCL0: 4000 PPM/8 小时
• 上游原料:乙醇 --> 钠 --> 三氯甲烷 --> 乙醇钠 --> 苯甲酰氯 --> 乙醇钠乙醇溶液
• MSDS 信息:原甲酸(三)乙酯(122-51-0).msds