Pilocarpine Hcl 盐酸毛果芸香碱

CAS 54-71-7 MFCD00012722

化学结构图

54-71-7
SMILES: Cl.CC[C@@H]1[C@@H](COC1=O)CC1=CN=CN1C |&1:3,4|

化学属性

Mol. FormulaC₁₁H₁₆N₂O₂ • HCl
Mol. Weight
Melting PointNo Data Available
TSCAYes
SolubilityDMSO 49 mg/mL Water 49 mg/mL Ethanol 49 mg/mL
Density0.1
Appearance powder
Boiling Point
Flash Point-

别名和识别编码

Chemical NamePilocarpine Hcl
Synonym (+)-PILOCARPINE HYDROCHLORIDE (+)-毛果芸香碱盐酸盐 (+)-毛果芸香碱盐酸盐,99% (3S,4R)-4,5-DIHYDRO-3-ETHYL-4-(1-METHYL-1H-IMIDAZOL-5-YLMETHYL)-2(3H)-FURANONE HYDROCHLORIDE (3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride (3S,4R)-4,5-二氢-3-乙基-4-(1-甲基-1H-咪唑-5-基甲基)-2(3H)-呋喃酮 盐酸盐 (3S,4R)-4,5-二氢-3-乙基-4-(1-甲基-1H-咪唑-5-基甲基)-2(3H)-呋喃酮盐酸盐 (3S-CIS)-3-ETHYLDIHYDRO-4-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2(3H)-FURANONE HYDROCHLORIDE (3s-cis)-ochlorid 3-ETHYL-4-[(1-METHYL-5-IMIDAZOLYL)METHYL]TETRAHYDROFURAN-2-ONE HYDROCHLORIDE 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-,monohydrochloride,(3S-cis)-2(3H)-Furanone 3-ethyldihydro-4-[(1-methyl-1h-imidazol-5-yl)methyl]-2(3h)-furanonmonohydr ALMOCARPINE HYDROCHLORIDE Almocarpine Ami-pilo Amistura P {
MDL Number-
CAS Number54-71-7
PubChem Substance ID24277862
Beilstein Registry Number4034491
EC Number200-212-5
Merck Number14,7424
Chemical Name Translation盐酸毛果芸香碱
Wiswesser Line NotationT5OVTJ C2 D1- DT5N CNJ C1 &GH
Canonical SMILES-
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分类

  • {SNA} Agonists, Alkaloids, Analytical Standards, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Chemical Structure,
  • {SNA} Analytical Standards,
  • {SNA} Pharmacopoeia,
  • {SNA} Agonists, Alkaloids, Analytical Standards, Analytical/Chromatography, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Signaling and Neuroscience, Chemical Structure, Cholinergics, Chromatography, Drugs of Abuse, Forensic and Veterinary Standards, Merck, Neuroscience, Neurotransmission, Neurotransmitters, P, 细胞生物学
  • {SNA} Additional Standards,
  • {SNA} Analytical Standards,

相关文献及参考

  • [2]. Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32.
  • [3]. Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11.
  • [4]. Wang RF, et al. Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Res. 2018 Mar 9;142:45-52.
  • [1]. Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.
  • [1]. Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.
  • [2]. Tonta MA, et al

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310+P330
  • P304+P340+P310
  • P403+P233
Hazard statements
  • H300+H330
  • H330 Fatal if inhaled 吸入致命
  • H300 Fatal if swallowed 吞食致命
  • H301 Toxic if swallowed 吞食有毒
Signal word
RTECSTK1450000
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S25 Avoid contact with eyes 避免眼睛接触；
Packing GroupIII
UN Number
Risk Statements
Storage condition -20 -20°C, Hygroscopic 2-8°C Hygroscopic 储存温度-20°C
Hazard Codes T+ T
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year: 29,39,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 200 ug/kg/7H-I
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 147,586,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 203 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Jap

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraarterial
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 353 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 130 mg/kg
SEX/DURATION            : female 7-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   85,79,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cattle
DOSE                    : 800 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 8,297,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 20 mg/kg
SEX/DURATION            : female 24-27 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
   AJANA2 American Journal of Anatomy.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.1-192, 1901-91.  Volume(issue)/page/year: 154,163,1979

其他信息

  • 盐酸毛果芸香碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 B21410 (+)-毛果芸香碱盐酸盐,99% (+)-Pilocarpine hydrochloride, 99% 5g 1084元 2010/05/25 B21410 (+)-毛果芸香碱盐酸盐,99% (+)-Pilocarpine hydrochloride, 99% 25g 3486元 2010/05/25 B21410 (+)-毛果芸香碱盐酸盐,99% (+)-Pilocarpine hydrochloride, 99% 1g 332元
  • MSDS 信息:(+)-Pilocarpine hydrochloride(54-71-7).msds
  • 匹鲁卡品 盐酸盐
  • 图谱信息:盐酸毛果芸香碱(54-71-7)红外图谱(IR1) 盐酸毛果芸香碱(54-71-7)红外图谱(IR2) 盐酸毛果芸香碱(54-71-7)Raman光谱
  • Sigma Aldrich:54-71-7(sigmaaldrich)
  • F:3-8-10
  • color:white
  • MOL 文件:54-71-7.mol
  • 敏感性:Hygroscopic
  • Alfa Aesar:(+)-毛果芸香碱盐酸盐,99% (+)-Pilocarpine hydrochloride, 99%(54-71-7)
  • 比旋光度:89 ° (C=5, H2O)

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids
  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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