Acetylsalicylic Acid 乙酰水杨酸

CAS 50-78-2 MFCD00002430

化学结构图

50-78-2
SMILES: CC(=O)Oc1ccccc1C(=O)O

化学属性

Mol. FormulaC9H8O4
Mol. Weight180.16
Melting Point134-136 °C
Density1.35
Flash Point250°(482°F)
TSCAYes
SolubilitySoluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml).
Stability对湿度敏感
Appearance 本品为白色结晶，m.p.138～140℃，不溶于水，溶于醇、醚等。 crystalline
Boiling Point272.96 °C at 760 mmHg

别名和识别编码

Chemical NameAcetylsalicylic Acid
Synonym Aspirin {LY} Aspirin {} {LY} Aspirin {} {} {LY} Aspirin {} {} {} {LY} Aspirin {} {} {} {} {LY} Aspirin {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number50-78-2
EC Number200-064-1
Beilstein Registry Number779271
MDL NumberMFCD00002430
Reaxys-RN779271
Merck Number851
PubChem Substance ID2244
Chemical Name Translation乙酰水杨酸
Wiswesser Line NotationQVR BOV1
LabNetwork Molecule IDLN00223310
InChIInChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
Canonical SMILESOC(C1=C(OC(C)=O)C=CC=C1)=O
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分类

  • {SNA} A to C, Application Index, Arachidonic Acid Cascade, Cell Signaling Enzymes, Chemopreventive Agents, Core Bioreagents, Cyclooxygenase, Cyclooxygenase (COX) Enzymes, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Lipids in Cell Signaling,
  • {SNA} A to C,
  • {SNA} Acetylsal

产品应用

  • 检定锰。有机合成。
  • 乙酰水杨酸靠抑制环化加氧酶（cyclooxygenase，前列腺素H合成酶)阻止前列腺索的生产，特别是针对COX-1同种型有很高的选择性。其抗血栓效果就是由于抑制了血小板中起凝血和血小板凝聚作用的COX-1。

相关文献及参考

  • Merck: 14,851 Beilstein:10(4)138
  • Merck: 14,851
  • Gilroy, D. W., et al., Differential effects of inhibitors of cyclooxygenase (COX-1 and COX-2) in acute inflammation. Eur. J. Pharmacol. 355 , 211-217, (1998)

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
RTECSVO0700000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
  • P301+P312
  • P302+P352
  • P304+P340
  • P304+P341
  • P305+P351+P338
  • P307+P311
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P342+P311
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
UN Number UN 1851 1851 2811
Packing GroupIII
Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 7,365,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 39 mg/kg/13D-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 139,453,1985

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Volume(issue)/page/year: 81,621,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   JNUDAT Journal of Nihon University School of Dentistry.  (Nihon University
   School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101, Japan)
    V.1-    1958-  Volume(issue)/page/year: 34,183,1992

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 100 mg/L
REFERENCE :
   ACYTAN Acta Cytologica.  (Science Printers and Pub., Inc., 2 Jacklynn Ct.,
   St. Louis, MO 63132) V.1-    1957-  Volume(issue)/page/year: 16,41,1972

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 36,1748,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1660 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 108 ug/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 75 mg/L
REFERENCE :
   NEZAAQ Nippon Eiseigaku Zasshi.  Japanese Journal of Hygiene.  (Nippon Eisei
   Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 17280 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Specific Developmental Abnormalities - respiratory system
   Reproductive - Effects on Newborn - Apgar score (human only)
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   92,478,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 546 mg/kg
SEX/DURATION            : female 37-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   CPEDAM Clinical Pediatrics (Philadelphia).  (Lippincott/Harper, Journal
   Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1962-
   Volume(issue)/page/year: 32,740,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 700 mg/kg
SEX/DURATION            : female 35-36 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   CPEDAM Clinical Pediatrics (Philadelphia).  (Lippincott/Harper, Journal
   Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1962-
   Volume(issue)/page/year: 34,174,1995

TYPE OF TEST            : T

其他信息

  • 用途五:是应用最早，最广和最普通解热镇痛药抗风湿药。具有解热、镇痛、抗炎、抗风温和抗血小板聚集等多方面的药理作用，发挥药效迅速，药效肯定，超剂量易于诊断和处理，很少发生过敏反应。常用于感冒发热,头痛、神经痛关节痛、肌肉痛、风湿热、急性内湿性关节炎、类风湿性关节炎及牙痛等。是《国家基本药物目录》列入的品种乙酰水杨酸也是其他药物的中间体。
  • 无气味。微带酸味。在干燥空气中稳定，在潮湿空气中逐渐水解成水杨酸和乙酸。遇沸水或溶于氢氧化钠碱溶液和碳酸碱溶液中全部分解。溶于乙醇、乙醚和氯仿。
  • 用途二:用于制造室外及有强光照射的结构件、器械部件，如汽车车身、农机部件、电表和电灯罩、道路标记等
  • 下游产品:华法林 --> 邻乙酰水杨酰氯 --> 2-乙酰氧基苯甲酸-4-乙酰氨基苯
  • 方法一:其制备方法是先将水杨酸与乙酐投入三口瓶中搅拌，反应温度不超过60℃，约1h后，反应结束，倒入冰水中，有结晶析出，过滤、干燥得产品。
  • 毒性分级:高毒
  • Alfa Aesar:O-乙酰基水杨酸,99% O-Acetylsalicylic acid, 99%(50-78-2)
  • 用途三:解热镇痛药，用于发热、疼痛及类风湿关节炎等
  • {Chemical
  • 乙酰水杨酸是什么:乙酰水杨酸又叫阿司匹林、醋柳酸、邻乙酰水杨酸，是由水杨酸与无水醋酸相作用而成的一种解热镇痛药。外观为白色结晶性粉末，纯品无臭，在干燥空气中稳定，遇潮即缓缓水解成水杨酸和醋酸，水溶液呈酸性反应。微溶于水，溶于乙醇、乙醚、氯仿、氢氧化钠溶液和碳酸钠溶液。乙酰水杨酸有解热镇痛、消炎、抗风湿作用，故常用于发热、头痛、肌肉痛、神经痛、风湿热、急性风湿性关节炎、痛风等；乙酰水杨酸也有抗血小板凝集作用，可用于预防动脉血栓、动脉粥样硬化、暂时性脑缺血、心肌梗塞；另外乙酰水杨酸还可用于治疗胆道蛔虫症、足癣等。 【药理作用】乙酰水杨酸是传统的解热镇痛药，同时有抗血小板聚集的作用。乙酰水杨酸在体内具有抗血栓的特性，能减少周围动脉内阻塞性血栓的形成。抑制血小板的释放反应以及内源性ADP、5-HT等的释放。因此，抑制血小板的第二相聚集而不抑制其第一相聚集。乙酰水杨酸的作用机制在于使血小板的环氧酶乙酰化，从而抑制了环内过氧化物的形成，TXA2的
  • 灭火剂:雾状水、泡沫、二氧化碳、砂土。
  • 下游产品:华法林 --> 邻乙酰水杨酰氯 --> 2-乙酰氧基苯甲酸-4-乙酰氨基苯酯
  • 乙酰水杨酸是什么:乙酰水杨酸又叫阿司匹林、醋柳酸、邻乙酰水杨酸，是由水杨酸与无水醋酸相作用而成的一种解热镇痛药。外观为白色结晶性粉末，纯品无臭，在干燥空气中稳定，遇潮即缓缓水解成水杨酸和醋酸，水溶液呈酸性反应。微溶于水，溶于乙醇、乙醚、氯仿、氢氧化钠溶液和碳酸钠溶液。乙酰水杨酸有解热镇痛、消炎、抗风湿作用，故常用于发热、头痛、肌肉痛、神经痛、风湿热、急性风湿性关节炎、痛风等；乙酰水杨酸也有抗血小板凝集作用，可用于预防动脉血栓、动脉粥样硬化、暂时性脑缺血、心肌梗塞；另外乙酰水杨酸还可用于治疗胆道蛔虫症、足癣等。 【药理作用】乙酰水杨酸是传统的解热镇痛药，同时有抗血小板聚集的作用。乙
  • Acros Organics:乙酰水杨酸 Acetylsalicyli
  • 邻乙酰水杨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1248801 乙酰水杨酸;2-乙酸基苯甲酸;阿司匹林;乙酰基柳酸;醋柳酸 100g 188元 2011/08/23 LA1248802 乙酰水杨酸;2-乙酸基苯甲酸;阿司匹林;乙酰基柳酸;醋柳酸 500g 383元 2011/08/23 L
  • Sigma Aldrich:50-78-2(sigmaaldrich)
  • color:white
  • 用途一:杨酸与乙酸。微溶于水，溶于乙醇、乙醚、氯仿，也溶于氢氧化碱溶液或碳酸溶液，同时分解。常用的解热镇痛药。用于解热、镇痛、抗风湿，促进痛风患者尿酸的排泄，抗血小板聚集及胆道蛔虫治疗。
  • 方法二:水杨酸乙酰化而得：在反应罐中加乙酐(加料量为水杨酸总量的0.7889倍)，再加入三分之二量的水杨酸，搅拌升温，在81-82℃反应40-60min。

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Enzyme Inhibitors - Core Bioreagents
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. A-AM - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. AN-AZ - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Culture 细胞培养
  3. Reagents and Supplements - Cell Culture
  4. Miscellaneous Reagents and Supplements - Reagents and Supplements
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C9 - Carboxylic Acids
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Lipids in Cell Signaling - Cell Signaling and Neuroscience
  5. Arachidonic Acid Cascade - Lipids in Cell Signaling
  6. Enzyme Inhibitors - Arachidonic Acid Cascade
  7. Cyclooxygenase - Enzyme Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Cyclooxygenase (COX) Enzymes - Cell Signaling Enzymes
  7. Cyclooxygenase Inhibitors - Cyclooxygenase (COX) Enzymes
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aromatic acids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids
  6. C8
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Dry Powder Media
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Cyclooxygenase (COX) Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Lipids in Cell Signaling
  5. Arachidonic Acid Cascade
  6. Arachidonic Acid
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Cyclin Dependent Kinases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Lipids
  4. Lipids in Cell Signaling
  5. Arachidonic Acid Cascade
  6. Arachidonic Acid