Salsalate 双水杨酸酯

CAS 552-94-3 MFCD00020252

化学结构图

552-94-3
SMILES: O=C(Oc1ccccc1C(=O)O)c1ccccc1O

化学属性

Mol. FormulaC14H10O5
Mol. Weight258
Density1.422
Melting Point139-151
TSCAYes
SolubilitySoluble in water (hydrolyzes slowly), DMSO (52 mg/ml at 25 °C), ethanol (52 mg/ml at 25 °C), DMF (~14 mg/ml), and methanol.
Stability对湿度敏感

别名和识别编码

Chemical NameSalsalate
CAS Number552-94-3
Synonym ######## 2-Carboxyphenyl salicylate 2-HYDROXYBENZOIC ACID 2-CARBOXYPHENYL ESTER 2-Hydroxybenzoic acid 2-carboxyphenyl ester 2-SALICYLOYLOXYBENZOIC ACID 2-Salicylsalicylic acid; 2-Hydroxybenzoic acid 2-carboxyphenyl ester; Amigesic; Diagen; Disalcid; Mono-gesic; Salflex; Salgesic; Salicylylsalicylic acid; Salsalate; Salsitab Diacesal Diplosal Disalicylic acid O-SALICYLOYLSALICYLIC ACID O-SALICYLSALICYLIC ACID SAA SALICYLIC ACID SALICYLATE SASAPYRINE Salical Salicylic Acid 2-Carboxyphenyl Ester, Salsalate Salicylic acid, bimolecular ester Salicylsalicylic acid Saloxium Sasapirin amigesic salgesic 双水杨酯,即水杨酰水杨酸 水杨基水杨酸
EC Number209-027-4
Beilstein Registry Number2590908
MDL NumberMFCD00020252
Reaxys-RN2590908
PubChem Substance ID87575737
Merck Number8339
Chemical Name Translation双水杨酸酯
Wiswesser Line NotationQVR BOVR BQ
LabNetwork Molecule IDLN00196870
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分类

  • {SNA} Arachidonic Acid Cascade, Bioactive Small Molecules, Cell Signaling and Neuroscience, Cyclooxygenase, Enzyme Inhibitors, Lipids in Cell Signaling, S, 细胞生物学
  • {SNA} Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Cyclooxygenase, Enzyme Inhibitors, Lipids in Cell Signali

产品应用

  • Usually used to study the effect on palmitate-induced insulin resistance and hepatic steatosis in obese rats.

相关文献及参考

  • [2]. Scheiman JM, et al. Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endoscopic studies in humans. Semin Arthritis Rheum. 1990;20(2):121-127.
  • [3]. González F, et al. Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2020;319(4):E744-E752.
  • Dromgoole, S.M., et al.: J. Pharm. Sci., 73, 1657 (1984),
  • Harrison, L.L., et al.: J. Pharm. Sci., 69, 1268 (1980),
  • [1]. Murthy SN, et al. Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats. Diabetes. 2010;59(12):3240-3246.
  • [1]. Murthy SN, et al. Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats. Diabetes. 2010;59(12):3240-3246.
  • [2]. Scheiman JM, et al. Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endos

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R50 Very toxic to aquatic organisms 对水生生物极毒
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
RTECSDH2080000
Storage condition Moisture Sensitive 储存温度-20°C 充氩保存
Hazard Codes 9
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
Packing GroupIII
UN Number 3077
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1020 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 22,1101,1980

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 2229 mg/kg/2Y-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   107,116,1987

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 665 mg/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   29,250,1971

其他信息

  • 用途:用作止痛消炎药
  • 双水杨酸酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 S0129 水杨酸2-羧基苯酯 2-Carboxyphenyl Salicylate 500G 1320元 2014/06/02 S0129 水杨酸2-羧基苯酯 2-Carboxyphenyl Salicylate 25G 306元 2010/06/21 133400250 双水杨酸酯 Salicylsalicylic acid 99% 25 GR 729元
  • EPA化学物质信息:Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester(552-94-3)
  • MOL 文件:552-94-3.mol
  • RTECS号:DH2080000
  • Salsalate
  • NIST化学物质信息:2-Carboxyphenyl salicylate(552-94-3)

系列性分类


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