Cyclamic Acid 环已烷氨基磺酸

CAS 100-88-9 MFCD00065234

化学结构图

100-88-9
SMILES: O=S(=O)(O)Nc1ccccc1

化学属性

Mol. FormulaC6H13NO3S
Mol. Weight179
Melting Point~180 °C (dec.)
SolubilityDMSO 36 mg/mL Water 36 mg/mL Ethanol 36 mg/mL
Appearance 无色结晶或白色结晶性粉末,有甜酸味。

别名和识别编码

Chemical NameCyclamic Acid
CAS Number100-88-9
Synonym Polycat 200 Cyclohexylsulfamic acid Cyclohexylsulfamic acid; N-Cyclohexylsulfamic acid Hexamic acid Cyclohexylaminesulfonic acid Cyclohexylaminesulfonic Acid cyclohexylaminesulphonicacid 环拉酸 N-CYCLOHEXYLSULFAMIC ACID 环己基氨基磺酸 Cyclohexylamidosulphuric acid Zyklamat Sucaryl hexamicacid cyclohexylamidosulfuricacid Cyclohexansulfamidsäure N-cyclohexylsulphamic acid N-Cyclohexylsulfamic acid 环己氨磺酸 Cyclohexanesulphamic acid cyclohexanesulphamicacid CYCLAMIC ACID 环己氨磺酸 环拉酸 Cyclohexylsulphamic acid cyclohexyl-sulfamicaci NSC 220327 仙客来酸 Cyclamate Sulfamic acid, N-cyclohexyl- Hexamic Acid CYCLOHEXYLSULFAMIC ACID N-Cyclohexylsulfamic Acid Cyclamic acid cyclohexylaminesulfonicacid Cyclohexanesulfamic acid N-Cyclohexylsulphamic acid Cyclohexanesulfamic Acid Cyclohexylamidosulfuric acid Cyclohexylamidosulfuric Acid cyclohexylsulfamic CYCLOHEXYL SULFAMIC ACID cyclohexylamidosulphuricacid cyclohexyl-amidosulfuric acid CYCLOHEXANESULFAMIC ACID Sulfamic acid, cyclohexyl- cyclohexylsulphamicacid Cyclohexylaminesulphonic acid Sucaryl acid 环己烷氨基磺酸
MDL NumberMFCD00065234
Beilstein Registry Number2208885
EC Number202-898-1
PubChem Substance ID7533
Reaxys-RN2208885
Merck Number2703
Chemical Name Translation环已烷氨基磺酸
LabNetwork Molecule IDLN00198139
InChIInChI=1S/C6H13NO3S/c8-11(9,10)7-6-4-2-1-3-5-6/h6-7H,1-5H2,(H,8,9,10)
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分类

  • {uni_hamburg} no charge; carbocycle; alicycle; 6RingOnly; 6ring; 1fragment
  • {Chemicalbook} 食品添加剂: 调味剂(风味增强剂): 甜味剂
  • Sulfur & Selenium Compounds
  • Amines
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonic/Sulfinic Acids, Sulfur Compounds
  • {SA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonic/Sulfinic Acids, Sulfur Compounds

产品应用

  • A non-nutritive sweetener.

相关文献及参考

  • Taylor, et al.: Food Cosmet. Toxicol., 6, 313 (1968),
  • Brantom, et al.: Food Cosmet. Toxicol., 11, 735 (1973),
  • Merck 14 ,2703
  • Beil. 12 ,IV,102
  • Short: III/5a Title: Structure Data of Organic Crystals: C ... C 13 Author: Schudt, E.; Weitz, G. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/5a Year: 1971 ISBN: 3-540-05177-5 ISBN: 978-3-540-05177-0 Internet Resource: DOI:10.1007/b19970 RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover Abstract: Volume III/5 offers a compitation as complete as possible of the space groups and lattice con-stants of all crystals which have been studied by means of X-rays, neutron and electron diffraction.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

WGK Germany2
RTECSGV6950000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
GHS Symbol
Storage condition 储存温度-20°C
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 22 gm/kg/77W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - hematuria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   JOURAA Journal of Urology.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1917-  Volume(issue)/page/year: 118,258,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 131 gm/kg/5Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   JOURAA Journal of Urology.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1917-  Volume(issue)/page/year: 118,258,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 164 gm/kg/6Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - hematuria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   JOURAA Journal of Urology.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1917-  Volume(issue)/page/year: 118,258,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#01774

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   225,551,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   225,551,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   225,551,1953

其他信息

  • 环拉酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30046280 环己胺磺酸 100g 138元 2011/04/16 C0486 N-环己基氨基磺酸 N-Cyclohexylsulfamic Acid 500G 2210元 2011/04/16 C0486 N-环己基氨基磺酸 N-Cyclohexylsulfamic Acid 25G 328元
  • 环己基氨基磺酸
  • 鉴别试验:溶解性(OT-42) 溶于水和乙醇。 沉淀试验配制2%试样液,用盐酸酸化,加氯化钡试液(TS-37)lml,如有混浊或沉淀发生则过滤。于澄清液中加10%亚硝酸钠液lml。应有白色沉淀形成。
  • 参考质量标准:FAO/WHO,1996 含量(以干基计) 98%~102% 干燥失重(105℃,1h) ≤1% 重金属(GT-16-2,试样量2g) ≤10mg/kg 环己基胺 ≤10mg/kg 二环己基胺(同“02304,环己基氨基磺酸钙”) ≤2mg/kg
  • 含量分析:准确称取试样约350mg,移入一250ml烧瓶中。加水50ml使之溶解,加酚酞试液(TS-167),用0.1mol/L氢氧化钠液滴定。每Ml0.1mol/L氢氧化钠液相当于C6H13NO3S 17.82mg。
  • 用途一:无营养甜味剂。
  • 毒性:ADI尚未规定(FAO/WHO,2001)。
  • 上游原料:氯磺酸 --> 环己胺
  • 下游产品:环己基氨基磺酸钠 --> 环己基氨基磺酸钙
  • MOL 文件:100-88-9.mol
  • 图谱信息:环拉酸(100-88-9)红外图谱(IR1) 环拉酸(100-88-9)质谱(MS) 环拉酸(100-88-9)红外图谱(IR2)
  • Sigma Aldrich:100-88-9(sigmaaldrich)
  • 方法一:由环己胺用氯磺酸或氨基磺酸盐磺化而成。
  • TCI Shanghai:环己基氨基磺酸 N-Cyclohexylsulfamic Acid,>;98.0%(T)(100-88-9)

系列性分类


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