(-)-Epicatechin (-)-表儿茶素

CAS 490-46-0 MFCD00075648

化学结构图

490-46-0
SMILES: Oc1cc(O)c2c(c1)OC(c1ccc(O)c(O)c1)C(O)C2

化学属性

Mol. FormulaC15H14O6
Mol. Weight290
Melting Point234-237
Density1.593
SolubilitySoluble in acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly).

别名和识别编码

Chemical Name(-)-Epicatechin
Synonym 表兒茶酚 CIS-2-[3,4-DIHYDROXYPHENYL]-3,4-DIHYDRO-2H-1-BENZOPYRAN-3,5,7-TRIOL EPICATECHIN, (+)- EPICATECHIN 3,3',4',5,7-PENTAHYDROXY-FLAVANE L-(-)-EPICATECHIN Ι-表儿茶酸 3,3',4',5,7-PENTAHYDROXYFLAVONE (-)-3,5,7,3',4'-PENTAHYDROXYFLAVAN 3,3',4',5,7-PENTAHYDROXYFLAVAN (+)-EPICATECHIN (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL (-)-CIS-3,3',4',5,7-PENTAHYDROXYFLAVANE (-)-epicatecho l-Acacatechin (-)-顺式-3,3′,4′,5,7-五羟基黄烷 Ι-表儿茶素 表儿茶素（EC) 3,5,7,3ˊ,4ˊ-五羟基黄烷 L-EPICATECHIN (-)-顺式-3,3′,4′,5,7-五羟基黄烷 (2R,3R)-2-(3,4-二羟基苯基)-3,4-二 CIS-3,3',4',5,7-PENTAHYDROXYFLAVANE
MDL NumberMFCD00075648
Beilstein Registry Number92760
CAS Number490-46-0
EC Number207-710-1
PubChem Substance ID72276
Chemical Name Translation(-)-表儿茶素
Merck Number13,1912
Reaxys-RN92760
InChIInChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1
LabNetwork Molecule IDLN00197927
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Acacia,
  • {SNA} Acacia, Antioxidant and Free Radical Scavengers, Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioflavonoids, Cell Stress, Chemopreventive Agents, E, Ephedra sinica, Flavonoids, Flavonols, and Flavanols, Ginkgo biloba, Humulus lupulus (Hops), Hypericum perforatum (St John's wort),
  • {SNA} Antioxidant and Free Radical Scavengers, Bioactive Small Molecule Alphabetical Index, Chemopreventive Agents, E, 一氧化氮和细胞应激, 抗氧化剂和细胞保护剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞应激, 细

产品应用

  • 抗氧剂,发现于巧克力中

相关文献及参考

  • [2]. Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260.
  • [3]. Nogueira L, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589(Pt 18):4615-31.
  • Merck: 13,1912
  • Merck: 13,1912 Beilstein: 17,V,8,447
  • [1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9.
  • [1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9.
  • [2]. Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegenera

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 0-10°C 2-8°C storage temp. 2-8°C 储存温度2-8℃ 贮存温度2-8℃
RTECSK3745000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PLMEAA Planta Medica.  (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart
   1, Fed. Rep. Ger.) V.1-    1953-  Volume(issue)/page/year: 42,75,1981

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 500 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

其他信息

  • 表儿茶素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 69010380 (-)-表儿茶素 100mg 40元
  • MSDS 信息:L-Epicatechin(490-46-0).msds
  • Sigma Aldrich:490-46-0(sigmaaldrich)
  • F:10-23
  • MOL 文件:490-46-0.mol
  • 图谱信息:表儿茶素(490-46-0)质谱(MS) 表儿茶素(490-46-0)红外图谱(IR2) 表儿茶素(490-46-0)核磁图( 1 HNMR) 表儿茶素(490-46-0)红外图谱(IR1) 表儿茶素(490-46-0)核磁图( 13 CNMR)

系列性分类

  1. Life Science 生命科学
  2. Cancer Research
  3. Chemopreventive Agents - Cancer Research
  4. Antioxidant and Free Radical Scavengers - Chemopreventive Agents
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. E - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Bioflavonoids - Phytochemicals by Chemical Classification
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Ginkgo biloba - Phytochemicals by Plant (Food/Spice/Herb)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Aromatics - Chemical Class
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Heterocyclics - Chemical Class
  5. Oxygen containing - Heterocyclics
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CA - CG - C
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. E - Alphabetic
  5. EP - E
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Alphabetical - Phytopharma Standards
  7. E - H - Alphabetical
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Heterocyclic Building Blocks - Chiral Building Blocks
  5. Benzopyrans - Heterocyclic Building Blocks
  1. Functional Group 官能团索引
  2. 1,2-diphenol
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals and Reagents
  4. Stains and Dyes
  5. Natural Dyes
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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