Tetracycline Hydrochloride 四环素盐酸盐
CAS 64-75-5 MFCD00078142
化学结构图
SMILES: CN(C)C1C(=O)C(C(N)=O)=C(O)C2(O)C(=O)C3=C(O)c4c(O)cccc4C(C)(O)C3CC12.Cl
化学属性
| Mol. Formula | C22H24N2O8.HCl |
|---|---|
| Mol. Weight | 481 |
| Melting Point | 220-223 |
| TSCA | Yes |
| Solubility | 50 G/L |
| Density | 1.177 |
| Appearance | powder |
| Refractive index | -253 ° (C=0.5, 0.1mol/L HCl) |
别名和识别编码
| Chemical Name | Tetracycline Hydrochloride |
|---|---|
| CAS Number | 64-75-5 |
| Synonym | Qidtet {Chemicalbook} TETRACYCLINE HCL {Chem Chlorowodorku tetracykliny [4S-(4?,4a?,5a?,6?,12a?]- [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride Amycin, hydrochloride Piracaps Diacycine S cancycline-25 潮霉素 A 均霉素 Bristacycline 托妥霉素 diacycine Tetracompren Tetra-wedel Tetracycline hydrochloride ALA TET 10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride,[4s-(4alpha,4a 12,12a-pentahydroxy-6-methyl-1,11-dioxo-1monohydrochlori cefracyclinetablets Medamycin Teline 盐酸四环素 Tetralution 盐酸四环 dumocyclin DESCHLOROBIOMYCIN NCI-C55561 amycin,hydrochloride 潮霉素 Vetquamycin-324 四环素 盐酸盐 ACHROM alatet [4s-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenec Tetraciclina cloridrato Tetrosol Sumycin Achromycin hydrochloride 5aalpha,6beta,12aalpha)]-alph Chlorhydrate de tetracycline Telotrex TETRACYCLINE HYDROCHLORIDE Tetrabakat Tet-Cy Quatrex Triphacyclin 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,m2-Naphthacenecarboxamide 盐酸三氯噻嗪 artomycin |
| Beilstein Registry Number | 14(4)2625 |
| PubChem Substance ID | 87560362 |
| MDL Number | MFCD00078142 |
| EC Number | 200-593-8 |
| Reaxys-RN | 3844873 |
| Merck Number | 9196 |
| Chemical Name Translation | 四环素盐酸盐 |
| Wiswesser Line Notation | L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ M1RQ &GH |
| LabNetwork Molecule ID | LN00242611 |
| InChI | InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Chemical Structure Class, Core Bioreagents,
- {SNA} Antiba
- {SNA} Antibiotic powders, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Chemical Structure Class, Core Bioreagents, Genetic Marker Selection, Research Essentials, Tetracyclines, 抗生素, 生化试剂, 细胞培养, 试剂和添加剂
- {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application,
- {SNA} Antibacterial,
产品应用
- 作用模式: 靠阻止胺酰基-tRNA至核糖体30S亚单位上阻止蛋白的合成。
- 抗菌谱:革兰氏阴性和阳性细菌。
- 阻断模式: 细胞壁渗透性缺失。
相关文献及参考
- Weiss, et al.: Antibiot. Chemother., 7, 374 (1957),
- Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),
- Merck 14 ,9196
- Beil. 14 ,IV,2627
- Aldrich MSDS 1 , 1654:B / Corp MSDS 1 (2), 3252:B / FT-IR 1 (2), 421:C / FT-IR 2 (2), 3103:A / RegBook 1 (2), 2097:M / Sax 6 , 2521 / Sigma FT-IR 1 (1), 720:D / Structure Index 1 , 332:C:1
安全信息
GHS Symbol
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P405 Store locked up. 上锁保管。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
- H362 May cause harm to breast-fed children 可能对母乳喂养的婴儿造成伤害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R36 Irritating to eyes 刺激眼睛
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R64 May cause harm to breast-fed babies 可能导致伤害脯乳期婴儿
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,445,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 157 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 10,197,1955
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,55,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2759 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other tha
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 200 mg/kg/7D-I TOXIC EFFECTS : Sense Org
TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 3 gm/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 12,357,1971
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 120 mg/L REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-344,1989
TYPE OF TEST : DNA damage TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 1 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 315,33,1994
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Mammary gland DOSE/DURATION : 31600 ug/L/24H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,261,1976
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent -
TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 50 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 3 mg/L REFERENCE : SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 600 mg/kg SEX/DURATION : female 8-13 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteis
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 6 gm/kg SEX/DURATION : female 9-14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 4,516,1970
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 900 mg/kg SEX/DURATION : female 8-13 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intrauterine SPECIES OBSERVED : Rodent - rat DOSE : 100 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 29,553,1984
其他信息
- 盐酸四环素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 233105000 盐酸四环素 Tetracycline hydrochloride , 'can be used as secondary standard' 500 MG 701元 2010/06/21 233100025 盐酸四环素 Tetracycline hydrochloride , 'can be used as secondary standard' 2.5 GR 2333元 2010/05/25 B21408 四环素盐酸盐, 98% Tetracycline hydrochloride, 98% 25g 449元
- MOL 文件:64-75-5.mol
- MSDS 信息:[4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride(64-75-5).msds
- 注意事项:注意：防潮湿，储存在避光通风处，结块不影响药效避免和碱性农药、污水混合，否则易失效本药现用现配，药液不能久存。
- Alfa Aesar:四环素盐酸盐,98% Tetracycline hydrochloride, 98%(64-75-5)
- 图谱信息:盐酸四环素(64-75-5)红外图谱(IR1) 盐酸四环素(64-75-5)红外图谱(IR2)
- Sigma Aldrich:64-75-5(sigmaaldrich)
- 广谱抗生素:盐酸四环素是一种广谱抗生素，高浓度时具杀菌作用，除了常见的革兰阳性菌、革兰阴性菌以及厌氧菌外，多数立克次体属、支原体属、衣原体属、非典型分枝杆菌属、螺旋体、放线菌属、炭疽杆菌、单核细胞增多性李斯特菌、梭状芽孢杆菌、奴卡菌属对本品敏感。本品对革兰阳性菌作用优于革兰阴性菌，但肠球菌属和耐青霉素的淋球菌对其耐药。本品对弧菌、布鲁菌属、弯曲杆菌、耶尔森菌等革兰阴性菌抗菌作用良好，对铜绿假单胞菌无抗菌活性。 抗菌机理在于药物能特异性地与细菌核糖体30S亚基的A位置结合，阻止氨基酰－tRNA在该位上的联结，从而抑制肽连的增长和影响细菌蛋白质的合成而产生抑菌作用，又由于它能够改变细菌胞浆膜的通透性，使之易在菌体内积聚，起到快速抑菌的效果。 盐酸四环素是四环素碱的盐酸盐,在生产过程中，经进一步合成、精制而成，纯度高，毒副作用小，贮存期长。口服吸收百分比远远高于四环素碱，进人人体后，血药浓度、尿药浓度、生物利用度均高于四环素碱，而且安全可靠、疗效确切，目前在欧美一些国家仍在广泛使用。 盐酸四环素首选用于治疗衣原体感染、立克次体病、支原体肺炎、回归热等非细菌性感染，也用于布鲁菌病、霍乱、兔热病、鼠咬热、炭疽、破伤风、鼠疫、放线菌病、气性坏疽和敏感细菌引起的呼吸系统、胆管、尿路感染及皮肤软组织感染等的治疗。
- 比旋光度:-252 ° (c=0.5, H2O)
- 用途二:作用模式: 靠阻止胺酰基-tRNA至核糖体30S亚单位上阻止蛋白的合成。抗菌谱:革兰氏阴性和阳性细菌。阻断模式: 细胞壁渗透性缺失。
- 用途一:属广谱抗生素
- F:8-10-23
- 溶解度:20 g/L水，5 g/L乙醇，不溶于醚、烃类和丙酮。
- TCI Shanghai:盐酸四环素 Tetracycline Hydrochloride,>;98.0%(T)(64-75-5)
- Acros Organics:四环素盐酸盐 Tetracycline hydrochloride, 'can be used as secondary standard'(64-75-5)
京ICP备2020036287号