Vitamin B12 维生素B12

CAS 68-19-9 MFCD00151092

化学结构图

68-19-9
SMILES:

化学属性

Mol. FormulaC63H88CoN14O14P
Mol. Weight1355.37
Density0.945
TSCAYes
Stability对热、湿度敏感
Melting Point>300°C
SolubilitySoluble in water (50 mg/ml), DMSO (75 mg/ml at 25 °C), and ethanol (10 mg/ml at 25 °C). Insoluble in chloroform, and acetone.

别名和识别编码

Chemical NameVitamin B12
Synonym Anacobin Berubigen Betalin 12 crystalline Betaline-12 Cotel Crystamin Cyanocobalamin, α-(5,6-Dimethylbenzimidazolyl)cyanocobamide Dimethy Dodecabee Duodecibin Embiol Erycytol Factor II Factor II (vitamin) Normocytin Sytobex Vibalt Vitamin B12 Vitamin B12 (Impurity) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {ALD} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {hazard_co α-(5,6-Dimethylbenzimidazolyl)cyanocobamide CN-Cb α-(5,6-Dimethylbenzimidazolyl)cyanocobamide CN-Cbl α-(5,6-Dimethylbenzimidazolyl)cyanocobamide CN-Cbl Cyanocob(III)alami
MDL NumberMFCD00151092
CAS Number68-19-9
EC Number200-680-0
Beilstein Registry Number4122889
PubChem Substance ID87565570
Merck Number10014
Chemical Name Translation维生素B12
Reaxys-RN4122889
InChIKeyGOXVFFNWRIUNJM-UHFFFAOYSA-L
Wiswesser Line NotationD C5656 B-5 B6 B5 S5 J&5 B-19- Q&6 N&5/B-N/DU/J&-M&J&- O& 9ABBBBCSTT V& AN-CO-&& B-N CN TN C
LabNetwork Molecule IDLN01740971
Canonical SMILESN#[C-][Co+3]123([N]4=CN(C(OC(CO)C5OP6([O-])=O)C5O)C7=C4C=C(C)C(C)=C7)[N]8=C9C(CCC(N)=O)C(CC(N)=O)(C)C8(C)C(C(CC(N)=O)C%10(CCC(NCC(C)O6)=O)C)[N-]1C%10=C(C)C(C(CCC(N)=O)C%11(C)C)=[N]2C%11=CC%12=[N]3C(C(CC(N)=O)(C)C%12CCC(N)=O)=C9C
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分类

  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Food & Beverage Standards, Nutraceuticals, Pharmaceutical Secondary Standards, Pharmaceutical Standards, Vitamin B, Vitamins, Water-Soluble Vitamins
  • {SNA} Nutrition Research, Vitamin B, Vitamin B12,

产品应用

  • A coenzyme for synthesis of nucleic acids and metabolism carbohydrates.

相关文献及参考

  • [2]. Banerjee, R. and S.W. Ragsdale, The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annu Rev Biochem, 2003. 72: p. 209-47.
  • For a review, see: Vitamins, W. Friedrich, Ed., de Gruyter, Berlin (1988), pp 837-928.
  • For monographs, see: B 12 (2 vols), D. Dolphon, Ed., Wiley-Interscience, N.Y. (1982); B 12 and B 12 -Proteins, B. Kraeutler, T Golding, Eds., Wiley-VCH, Weinheim (1998).
  • For review of biosynthesis, see: Angew. Chem. Int. Ed., 32, 1223 (1993).
  • Merck: 14,10014
  • Merck: 14,10014 Beilstein: 26,IV,3117
  • [1]. http://en.wikipedia.org/wiki/Vitamin_B12
  • [1]. http://en.wikipedia.org/wiki/Vitamin_B12
  • [2]. Banerjee, R. and S.W. Ragsdale, The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annu Rev Biochem, 2003. 72: p. 209-47.

安全信息

Signal word Warning
GHS Symbol
WGK Germany1
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
RTECSGG3750000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 0-10 0-10°C 2-8°C 避光密封保存。 2-8°C, sealed storage, away from moisture Hygroscopic 储存温度2-8℃ 储存温度2-8℃,充氩保存 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1364 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 49,278,1950

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2727 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - other changes
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 49,278,1950

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 42,114,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 84 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 67,377,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 168 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 67,377,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 115 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 242,263,1973

其他信息

  • 300℃不溶化。有吸湿性，在空气中能吸收12%水分，其含水结晶在空气中稳定。在210-220℃时颜色变深。能溶于水和醇，不溶于丙酮、氯仿和醚。其溶液呈中性，在pH4.5-5时最稳定。在碱性或强酸性溶液中可缓缓水解。无臭，无味。
  • Vitamin B12 (Cyanocobalamin) is part of a coenzyme needed for the synthesis of proteins and nucleic acids, and for the metabolism of carbohydrates. Vitamin B12 plays a role in the synthesis of myelin. The compound is also used as an antipernicious anemia factor.

系列性分类

  1. Life Science 生命科学
  2. Cell Culture 细胞培养
  3. Reagents and Supplements - Cell Culture
  4. USP Chemicals and Reagents - Reagents and Supplements
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Panax ginseng - Phytochemicals by Plant (Food/Spice/Herb)
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Cofactors - Enzymes, Inhibitors, and Substrates
  5. Other Cofactors 其他辅助因子
  1. Life Science 生命科学
  2. Cell Culture 细胞培养
  3. Serum-free Media - Cell Culture
  4. Insect Platform - Serum-free Media
  5. Companion Products and Reagents - Insect Platform
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CO - CZ - C
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Vitamins - Nutrition Research
  4. Vitamin B - Vitamins
  5. Vitamin B12 - Vitamin B
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Metal Compounds 金属化合物
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Porphyrins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Vitamins
  4. Vitamin B1
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Reagents and Supplements
  5. Mycoplasma Detection
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cofactors
  5. Acyl Transfer Reagents
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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