(E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide (E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺
CAS 133550-30-8 MFCD00209833
化学结构图
SMILES: N#C/C(=C\c1ccc(O)c(O)c1)C(=O)NCc1ccccc1
化学属性
| Mol. Formula | C17H14N2O3 |
|---|---|
| Mol. Weight | 294.3 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide |
|---|---|
| Synonym | AG 490; AG490; AG-490; Tyrphostin AG 490 |
| Chemical Name Translation | (E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺 |
| Formula | C17H14N2O3 |
| IUPAC Name | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide |
| InChIKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| InChI | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| Canonical SMILES | O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2 |
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产品应用
- Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death.
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