2-(5-(4-Bromobenzylidene)-4-Oxo-2-Thioxothiazolidin-3-Yl)-3-Methylbutanoic Acid 2-(5-(4-溴苯基亚甲基)-4-氧代-2-硫代噻唑-3-基)-3-甲基丁酸

CAS 300817-68-9 MFCD03453544

化学结构图

300817-68-9
SMILES: CC(C)C(C(O)=O)N1C(=S)S/C(=C/C2=CC=C(Br)C=C2)/C1=O

化学属性

Mol. FormulaC15H14BrNS2O3
Mol. Weight400.31

别名和识别编码

Chemical Name2-(5-(4-Bromobenzylidene)-4-Oxo-2-Thioxothiazolidin-3-Yl)-3-Methylbutanoic Acid
Synonym 5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid BH3I-1
MDL NumberMFCD03453544
Chemical Name Translation2-(5-(4-溴苯基亚甲基)-4-氧代-2-硫代噻唑-3-基)-3-甲基丁酸
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分类

  • {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, B, Bioactive Small Molecule Alphabetical Index, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience

相关文献及参考

  • [2]. Degterev A, et al. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol. 2001 Feb;3(2):173-82.
  • [3]. Porter JR, et al. Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.
  • [1]. Wang L, et al. Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
  • [1]. Wang L, et al. Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
  • [2]. Degterev A, et al. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol. 2001 Feb;3(2):173-82.
  • [3]. Porter JR, et al. Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. Chem

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xn
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. B - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Inducers - Apoptosis and Cell Cycle
  1. Medical Research Areas
  2. Metabolism
  3. E1/E2/E3 Enzyme  (E1/E2/E3泛素酶)

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