Malonamide 丙二酰胺

CAS 108-13-4 MFCD00008034

化学结构图

108-13-4
SMILES: NC(=O)CC(N)=O

化学属性

Mol. FormulaC3H6N2O2
Mol. Weight102.09
Melting Point172-175°C
TSCAYes
Solubility180 G/L (20 ºC)
Density1.281
Stability对湿度敏感
Appearance 丙二酰胺(108-13-4)为白色单斜针状结晶。熔点170℃（171.5-172.5℃）。在8℃水中的溶解度为8.3g/100ml，不溶于醇、醚和苯。
Boiling Point460.9°C at 760 mmHg

别名和识别编码

Chemical NameMalonamide
CAS Number108-13-4
Synonym Malonamide {LY} Malonamide {} {LY} Malonamide {} {} {LY} Malonamide {} {} {} {LY} Malonamide {} {} {} {} {LY} Malonamide {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Malonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00008034
PubChem Substance ID87572145
Beilstein Registry Number1751401
EC Number203-553-8
Reaxys-RN1751401
Chemical Name Translation丙二酰胺
Wiswesser Line NotationZV1VZ
LabNetwork Molecule IDLN00188325
Canonical SMILESO=C(N)CC(N)=O
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分类

  • {uni_hamburg} no charge; amide; 1fragment
  • {SNA} Amides, Biochemicals and Reagents, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Derivatization agents, Luminescent Compounds/Detection, Organic Building Blocks, Wavelength Index
  • Miscellaneous Reagents
  • {SNA} Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Derivatization agents, Organic Building Blocks, Wavelength Index, 发光化合物及其检测, 生化试剂
  • Amines
  • Aliphatics

产品应用

  • 有机合成。

相关文献及参考

  • Reagent for fluorimetric determination of reducing carbohydrates: Anal. Chim. Acta, 108, 421 (1979).
  • Katagi T., et al.: Chem. Pharm. Bull., 33, 4878 (1985),
  • Short: EINECS
  • Short: III/5a
  • Short: III/10a
  • Beilstein:2,582

安全信息

RTECSON9125000
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   34,1196,1940

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 11,1383,1977

GHS Symbol

其他信息

  • 方法一:由丙二酸二乙酯与氨反应而得。将氨水加入搪瓷桶内，冷至25℃以下，在搅拌下慢慢加入丙二酸二乙酯，反应温度在20℃左右，反应完后在室温放置两天。滤出底部结晶，减压浓缩，加入脱色炭，经抽滤，冷却结晶，于80℃干燥，粉碎即为成品。
  • 上游原料:脱色炭
  • MSDS 信息:Malonamide(108-13-4).msds
  • 下游产品:2-苯基丙二酰胺 --> 4,6-二溴嘧啶
  • 海关编码:29241900
  • Sigma Aldrich:108-13-4(sigmaaldrich)
  • 水中的溶解度为8.3g/100ml，不溶于醇、醚和苯。
  • 丙二酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0027 丙二酰胺 Malonamide 25G 311元 2014/06/02 M0027 丙二酰胺 Malonamide 500G 2420元 2010/06/21 156720050 丙二酰胺 Malonamide 97% 5 GR 196元
  • Acros Organics:丙二酰胺 Malonamide, 97%(108-13-4)
  • 用途二:用于有机合成。
  • 图谱信息:丙二酰胺(108-13-4)质谱(MS) 丙二酰胺(108-13-4)红外图谱(IR2) 丙二酰胺(108-13-4)核磁图( 13 CNMR) 丙二酰胺(108-13-4)红外图谱(IR1)
  • TCI Shanghai:丙二酰胺 Malonamide,>;98.0%(N)(108-13-4)
  • 用途一:主要用作有机合成的原料
  • Alfa Aesar:丙二酰胺,98% Malonamide, 98%(108-13-4)
  • MOL 文件:108-13-4.mol
  • The malonamide derivatives are obtained by the one-pot, five-component condensation reaction of isocyanide, Meldrum′s acid, arylidene malononitrile, and two amine molecules in CH2Cl2.

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Detection - Fluorescent Probes, Labels, Particles and Stains
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Hydrazides - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Hydrazides - Carbonyl Compounds

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