Propyl chloroformate 氯甲酸丙酯

CAS 109-61-5 MFCD00000649

化学结构图

109-61-5
SMILES: CCCOC(=O)Cl

化学属性

Mol. FormulaC4H7ClO2
Mol. Weight123
Density1.09
Refractive index1.4020 to 1.4050
Boiling Point105-106
Vapor Pressure0.87 psi ( 20 °C)
Flash Point28°C(lit.)
Solubility不溶于水，溶于醇、乙醚、苯等多数有机溶剂。

别名和识别编码

Chemical NamePropyl chloroformate
CAS Number109-61-5
EC Number203-687-7
Beilstein Registry Number3(4)24
MDL NumberMFCD00000649
Synonym 1-propyl chlorocarbonate 氯甲酸(正)丙酯 propyl chloroformate chloroformic acid propylester n-propyl chloroformate Carbonochloridic acid, propyl ester CHLOROFORMIC ACID N-PROPYL ESTER CHLOROFORMIC ACID PROPYL ESTER Carbonochloridic acid, propylester N-PROPYL CHLOROFORMATE chlorocarbonic acid propyl ester Propyl chloroformate NORMAL PROPYL CHLOROFORMATE (NPCF) carbonochloridic acid propyl ester 氯碳酸丙酯 Proply chloroformate propyl chloroformate chloro-formicacipropylester Formic acid, chloro-, propyl ester Propyl chloroformate: (Propyl chlorocarbonate) n-Propyl chlorocarbonate 氯甲酸丙酯 PROPYL CHLOROFORMATE N-丙基氯甲酸酯 chlorocarbonicacidpropylester Chlorameisensäure-n-propylester 氯甲酸正丙酯 Propyl chloridocarbonate n-Propylchlorformiat n-Propyl chloroformate NPCF n-Propyl Chloroformate; Carbonochloridic acid propyl ester; Chloroformic acid propyl ester PROPYL CHLOROCARBONATE Propyl chlorocarbonate
PubChem Substance ID7998
Reaxys-RN906817
Merck Number7848
Chemical Name Translation氯甲酸丙酯
Wiswesser Line NotationGVO3
LabNetwork Molecule IDLN00224681
InChIInChI=1S/C4H7ClO2/c1-2-3-7-4(5)6/h2-3H2,1H3
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分类

  • {SNA} Acid Halides, Analytical Reagents, Analytical/Chromatography, Building Blocks, Carbonyl Chlorides, Carbonyl Compounds, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents HPLC, Fluorescence, Organic Building Blocks
  • {uni_hamburg} no charge; carbonyl chloride; 1fragment

相关文献及参考

  • Short: III/20a
  • Merck:13,7940 Beilstein:3(4)24
  • Merck:13,7940
  • Short: II/14a
  • Short: III/38B

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R10 Flammable 易燃
  • R11 Highly flammable 非常易燃
  • R23 Toxic by inhalation 吸入有毒
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H226 Flammable liquid and vapour 易燃液体和蒸气
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSLQ6830000
Hazard Codes 6.1 F,T T
UN Number 2740
Storage condition 0-10 储存温度2-8℃ 0-10°C
Packing GroupI
Hazard Class6.1/3, 8
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 4,758,1978

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 319 ppm/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 4,758,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 4,758,1978

Restrict 危险品

其他信息

  • Sigma Aldrich:109-61-5(sigmaaldrich)
  • 储运特性:库房通风低温干燥; 与氧化剂, 碱类, 食品分开储运
  • 灭火剂:干粉, 砂土, 泡沫, 二氧化碳
  • 蒸气压:0.87 psi ( 20 °C)
  • 方法一:其制备方法是在通光气釜内加入正丙醇，启动搅拌，然后通过光气流量计通入光气，通光气温度为30℃左右，继续通光气若干小时，接近终点时取样分析，达标后停止通光气，冷却，然后通氮气赶走光气和氯化氢，对光气进行破坏，取样分析为产品。反应方程式：CH 3 CH 2 CH 2 OH+COCl 2 →ClCOOCH 2 CH 2 CH 3
  • 毒性分级:高毒
  • 用途二:氯甲酸正丙酯是杀菌剂霜霉威的中间体。
  • 上游原料:盐酸 --> 流量计
  • 可燃性危险特性:可燃; 遇水, 或受热放出有毒氯化氢气体
  • TCI Shanghai:氯甲酸正丙酯 Propyl Chloroformate,>;95.0%(T)(109-61-5)
  • MSDS 信息:氯甲酸(正)丙酯(109-61-5).msds
  • 氯甲酸丙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010348 氯甲酸正丙酯 100ml 300元 2011/04/16 C0929 氯甲酸丙酯 Propyl Chloroformate 500ML 2470元 2011/04/16 C0929 氯甲酸丙酯 Propyl Chloroformate 25ML 278元
  • 外观性质:无色液体。
  • 用途一:用作浮选剂及有机合成试剂
  • MOL 文件:109-61-5.mol
  • 图谱信息:氯甲酸丙酯(109-61-5)Raman光谱 氯甲酸丙酯(109-61-5)核磁图( 1 HNMR) 氯甲酸丙酯(109-61-5)红外图谱(IR1) 氯甲酸丙酯(109-61-5)质谱(MS) 氯甲酸丙酯(109-61-5)核磁图( 13 CNMR)
  • 急性毒性:口服-小鼠 LD50: 650 毫克/公斤
  • 类别:有毒物品

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds

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