N,N’-Dimethylhydrazine Dihydrochloride N,N’-二甲基肼二盐酸盐

CAS 306-37-6 MFCD00012522

化学结构图

306-37-6
SMILES: CNNC.Cl.Cl

化学属性

Mol. FormulaC2H8N2·2HCl
Mol. Weight133.02
Melting Point167-169 °C (dec.)(lit.)
Appearance 二甲基肼吡啶(306-37-6)为白色结晶。熔点170℃（分解）。易溶于水和乙醇。有潮解性。
Density0.759
Stability对湿度和空气敏感

别名和识别编码

Chemical NameN,N’-Dimethylhydrazine Dihydrochloride
Synonym 1,2-Dimethylhydraziniumdichlorid N,N'-dimethylhydrazine dihydrochloride (sym.) sym.-Dimethylhydrazindihydrochlorid 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE 1,2-二甲基肼二盐酸盐 N N,N′-二甲基肼 二盐酸盐 1,2-DimethylhydrazinediHCl N,N'-Dimethylhydrazine dihydrochloride 二甲基 1,2-二甲基肼二盐酸盐 N,N'-DIMETHYLHYDRAZINE DIHYDROCHLORIDE N,N'-Dimethylhydrazinium dichloride N,N-二甲基肼二盐酸盐 sym-Dimethylhydrazine dihydrochloride 1 2-二甲基肼二盐酸 N,N'-Dimethylhydrazindihydrochlorid 1,2-dimethylhydrazine dihydrochloride {uni_hamburg 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE, 9 9+% 1,2-二甲肼盐酸盐 N,N&# SYM-DIMETHYLHYDRAZINE DIHYDROCHLORIDE 1,2-Dimethylhydrazine dihydrochloride (sym.) N,N'-Dimethylhydrazine (sym.) dihydrochloride 1,2-Dimethylhydrazin Dihydrochlorid 1,2-DIMETHYLHYDRAZINE 2HCL N,N'-Dimethylhydraziniumdichlorid Hydrazine, 1,2-dimethyl-, dihydrochloride N,N'-dimethylhydrazine dihydrochloride 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE (SYM-, N,N''-) 98+% 1,2-dimethyl-hydrazindihydrochloride N,N′-二甲基肼（对称） 二盐酸盐 N,N'-DIMETHYLHYDRAZINE DI HCL (SYM) 1,2-Dimethylhydrazine dihydrochloride, N,Nμ-Dimethylhydrazine (sym.) dihydrochloride 二甲基肼 对称二甲基肼二盐酸盐 N,N′-二甲基肼（对称） 二盐酸盐;二甲基肼吡啶 1,2-Dimethylhydrazine dihydrochloride 1,2-dimethylhydraziniumdichloride
MDL NumberMFCD00012522
CAS Number306-37-6
PubChem Substance ID87567375
Beilstein Registry Number4,547
EC Number206-183-5
Reaxys-RN3905684
Merck Number3248
Chemical Name TranslationN,N’-二甲基肼二盐酸盐
Wiswesser Line Notation1MM1 &GH 2
LabNetwork Molecule IDLN01741398
InChIInChI=1S/C2H8N2.2ClH/c1-3-4-2;;/h3-4H,1-2H3;2*1H
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分类

  • {uni_hamburg} no charge; 3fragments; ionic
  • {SA} Building Blocks, Chemical Synthesis, Hydrazines, Nitrogen Compounds, Organic Building Blocks

产品应用

  • 诱变剂,科学实验中用于诱导结肠癌。

相关文献及参考

  • Short: III/20a Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei D ... Cl Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/20a Year: 1988 Keyword: NQR ISBN: 3-540-18161-X ISBN: 978-3-540-18161-3 Internet Resource: DOI:10.1007/b31153 RefComment: IX,677 pages. Hardcover Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310+P330
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P405 Store locked up. 上锁保管。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
Hazard statements
  • H350 May cause cancer 可能致癌
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
RTECSMV2800000
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Signal word Danger
Hazard Codes T,N T;N
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
  • R45 May cause cancer 可能致癌
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R51/53
UN Number UN 2811 6.1/PG 3 2811
Packing GroupIII
Hazard Class6.1
Storage condition 易吸潮，密封保存 充氩保存 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg/16W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Gastrointestinal - tumors
REFERENCE :
   VAPHDQ Virchows Archiv A: Pathological Anatomy and Histology.  (Berlin, Fed.
   Rep. Ger.) V.362-397, 1974-82

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2190 mg/kg/73W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   38,647,1976

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - colon tumors
REFERENCE :
   APLMAS Archives of Pathology and Laboratory Medicine.  (AMA, 535 N. Dearborn
   St., Chicago, IL 60610) V.1-5(2), 1926-28; V.100-    1976-
   Volume(issue)/p

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg/16W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Gastrointestinal - tumors
REFERENCE :
   VAPHDQ Virchows Archiv A: Pathological Anatomy and Histology.  (Berlin, Fed.
   Rep. Ger.) V.362-397, 1974-82.  Volume(issue)/page/year: 384,263,1979

{ha

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 122 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A062-138

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 32,383,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOS

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A062-138

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,3063,1978

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 15 mg/kg
REFERENCE :
   VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.1-    1968-
   Volume(issue)/page/year: 36,47,1981

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1700 ug/kg/2D (Continuous)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Multiple routes
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 395,2

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 68,31,1979

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   CALEDQ Cancer Letters (Sh

TY

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 200 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   APTOD9 Abstracts of Papers, Society of Toxicology.  Annual Meetings.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
   Volume(issue)/page/year: 19,A71,1980

其他信息

  • TCI Shanghai:1,2-二甲基肼二盐酸盐 1,2-Dimethylhydrazine Dihydrochloride,>;98.0%(T)(306-37-6)
  • 用途一:用于有机合成。
  • MOL 文件:306-37-6.mol
  • Sigma Aldrich:306-37-6(sigmaaldrich)
  • 上游原料:乙醇 --> 盐酸 --> 四氢呋喃 --> 乙酸 --> 氢化钠 --> 硫酸二甲酯 --> 碘甲烷 --> 水合肼 --> 4-甲苯磺酰氯 --> 苯甲酰氯 --> 硫酸肼 --> 1,1-二甲基肼 --> 二苯甲酰肼
  • 用途二:诱变剂,科学实验中用于诱导结肠癌。
  • 二甲基肼吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D0741 1,2-二甲基肼二盐酸盐 1,2-Dimethylhydrazine Dihydrochloride 25G 1240元 2010/06/21 116330100 二甲基肼吡啶 sym-Dimethylhydrazine dihydrochloride 99+% 10 GR 1123元
  • 方法一:由苯甲酰氯与硫酸肼反应生成对称二苯甲酰肼，再与硫酸二甲酯反应得到对称二苯甲酰二甲肼，最后将其与盐酸一起回流2小时，进行水蒸气蒸馏，将剩余物减压蒸发至干，结晶出对称二甲肼盐酸盐。
  • Acros Organics:1 2-二甲基肼二盐酸 sym-Dimethylhydrazine dihydrochloride, 99+%(306-37-6)
  • 易溶于水和乙醇。有潮解性。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Hydrazines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines

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