Benzbromarone 苯溴马隆

CAS 3562-84-3 MFCD00078962

化学结构图

3562-84-3
SMILES: CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1

化学属性

Mol. FormulaC17H12Br2O3
Mol. Weight424
Melting Point150.0 to 154.0 deg-C

别名和识别编码

Chemical NameBenzbromarone
CAS Number3562-84-3
Synonym ######## (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone (3,5-Dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)ketone (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-methanon (3,5-二溴-4-羟基苯基)(2-乙基-3-苯并呋喃基)甲酮 (3,5-二溴-4-羟基苯基)(2-乙基-3-苯并呋喃基)甲酮;3-(3,5-二溴-4-羟基苯甲酰基)-2-乙基苯并呋喃 3,5-Dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl ketone 3,5-dibromo-4-hydroxyphenyl-2-ethylbenzo[b]furan-3-yl ketone 3,5-dibromo-4-hydroxyphenyl2-ethyl-3-benzofuranylketone 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-benzofura 3-[3,5-DIBROMO-4-HYDROXYBENZOYL]-2-ETHYLBENZOFURAN AL, Benzbromaron Acifugan BENZ BENZBROMARONE BENZBROMARONE, MM(CRM STANDARD)
MDL NumberMFCD00078962
EC Number222-630-7
PubChem Substance ID2333
Chemical Name Translation苯溴马隆
Reaxys-RN273668
Merck Number1065
Wiswesser Line NotationT56 BOJ C2 DVR DQ CE EE
Beilstein Registry Number0273668
LabNetwork Molecule IDLN01264882
InChIInChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
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分类

  • {SNA} Analytical Standards, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, 分析/色谱
  • Heterocycles
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, B, BA - BH, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, 分析/色谱
  • Pharmaceuticals
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BA - BH, Bioactive Small Molecules, Cell Biology, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards,

产品应用

  • Benzbromarone is a uricosuric agent used in the treatment of gout and hyperuricemia. Studies show that use of Benzbromarone results in less complications than other uricosuric agent such as Allopurin

相关文献及参考

  • Heel, R.C. et al.: Drugs, 14, 349 (1977); Perez-Ruiz, F. et al.: Ann. Rheum. Dis., 57, 545 (1998);

安全信息

Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
UN Number UN 2811 6.1/PG 3 2811
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P203
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P310+P330
  • P301+P316
  • P308+P313
  • P318
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
WGK Germany3
Signal word Danger
RTECSOB1804200
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Packing GroupIII
Storage condition 2-8°C 储存温度:2-8°C
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,232,1979

T

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 248 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,232,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 77 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,341,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest publi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 360 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 16,1521,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 180 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 16,1521,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1320 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 16,1521,1979

其他信息

  • Sigma Aldrich:3562-84-3(sigmaaldrich)
  • MOL 文件:3562-84-3.mol
  • 用途一:用于治疗痛风、高尿酸血症

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BA - BH - B
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BA - BH - B
  1. Medical Research Areas
  2. Metabolism
  3. Xanthine Oxidase  (黄嘌呤氧化酶)

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