Butein 紫铆因
CAS 487-52-5 MFCD00017300
化学结构图
SMILES: O=C(/C=C/c1ccc(O)c(O)c1)c1ccc(O)cc1O
化学属性
| Mol. Formula | C15H12O5 |
|---|---|
| Mol. Weight | 272 |
| Appearance | solid |
| Solubility | DMSO: >;50 mg/mL |
| Melting Point | 216°C |
别名和识别编码
| Chemical Name | Butein |
|---|---|
| Synonym | 1-(2,4-DIHYDROXYPHENYL)-3-(3,4-DIHYDROXYPHENYL)-2-PROPEN-1-ONE 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one 2′,3,4,4′-Tetrahydroxychalcone 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one 2',3,4,4'-Tetrahydroxychalcone 2′,3,4,4′-Tetrahydroxychalcone 2',3,4,4'-TETRAHYDROCHALCONE 2',3,4,4'-TETRAHYDROXYCHALCONE 2',3,4,4'-Tetrahydroxychalcone 2',4',3,4-TETRAHYDROXYCHALCONE 3,4,2',4'-TETRAHYDROXYCHALCONE 40-0400 BUTANOL BUTEIN BUTEIN WITH HPLC BUTEIN(SH) MFCD00002964 紫铆因 紫铆查尔酮 |
| MDL Number | MFCD00017300 |
| PubChem Substance ID | 135727171 |
| CAS Number | 487-52-5 |
| EC Number | 207-659-5 |
| Chemical Name Translation | 紫铆因 |
| Reaxys-RN | 2056928 |
| LabNetwork Molecule ID | LN01278723 |
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分类
- {SNA} Antitumor Agents, B, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, EGFR Tyrosine Kinase Inhibitors, Enzyme Inhibitors, Epidermal Growth Factor Receptor (EGFR) and Src, Kinase/Phosphatase Biol
- {SNA} B, Bioactive Small Molecule Alphabetical Index, EGFR Ty
相关文献及参考
- [2]. Yang EB, et al. Butein, a specific protein tyrosine kinase inhibitor.Biochem Biophys Res Commun. 1998 Apr 17;245(2):435-8.
- [3]. Zhang L, et al. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.Int J Mol Med. 2015 Oct;36(4):957-66.
- Aizu, E., et al., Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects. Carcinogenesis 7 , 1809-1812, (1986) 摘要
- Iwashita, K., et al., Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci. Biotechnol. Biochem. 64 , 1813-1820, (2000) 摘要
- Kim, N.Y., et al., Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. Pharmacol. Toxicol. 88 , 261-266, (2001) 摘要
- Yang, E.
安全信息
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P312
- P330 Rinse mouth. 漱口
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
其他信息
- color:yellow
- MOL 文件:487-52-5.mol
- Sigma Aldrich:487-52-5(sigmaaldrich)
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