Aldosterone 醛固酮

CAS 52-39-1 MFCD00051136

化学结构图

52-39-1
SMILES: CC12CCC(=O)C=C1CCC1C2C(O)CC2(C=O)C(C(=O)CO)CCC12

化学属性

Mol. FormulaC21H28O5
Mol. Weight360
Melting Point170-172°C

别名和识别编码

Chemical NameAldosterone
Synonym (+)-Aldosterone (11BETA)-11,21-DIHYDROXY-3,20-DIOXO-PREGN-4-EN-18-AL 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al 11β,21-Dihydroxypregn-4-ene-3,18,20-trione 18-Aldocorticosterone Reichstein X 11β,21-Dihydroxypregn-4-ene-3,18,20-trione 11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al 11-BETA,18-EPOXY-18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE 11B-21-DIHYDROXY-3,20-DIOXO-4-PREGNAN-18-AL 11BETA,21-DIHYDROXY-3,20-DIOXO-4-PREGNEN-18-AL 11BETA,21-DIHYDROXYPREGN-4-ENE-3,18,20-TRIONE 11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al 11β,21-Dihydroxypregn-4-ene-3,18,20-trione 18-Aldocorticosterone Reichstein X 18-ALDOCORTICOSTERONE 18-Aldocorticosterone 18-KETOCORTICOSTERONE 18-Oxocorticosterone 21-dihydroxy-3,20-dioxo-1(11-beta)-pregn-4-en-18-a 21-dihydroxy-3,20-dioxo-1(11beta)-pregn-4-en-18-a 4-PREGNEN-11-BETA, 21-DIOL-3,18,20-TRIONE 4-PREGNEN-11-BETA,21-DIOL-3,20-DIONE 18-AL 4-PREGNEN-18-AL-11-BETA,21-DIOL-3,20-DIONE 4-PREGNEN-18-AL-11B,21-DIOL-3,20-DIONE ALDOSTERONE Aldocorten Aldocortene Aldocortin Aldosterone ELECTROCORTIN Electrocortin Elektrocortin LECTROCORTIN REICHSTEIN X Reichstein X d-Aldosterone 醛固酮 醛固醇酮 醛甾酮
MDL NumberMFCD00051136
CAS Number52-39-1
PubChem Substance ID5839
Beilstein Registry Number3224996
EC Number200-139-9
Chemical Name Translation醛固酮
Merck Number13,224
Wiswesser Line NotationL E5 B666 OV CU MUTJ A1 E1 FV1
LabNetwork Molecule IDLN01266326
InChIInChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
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分类

  • {SNA} A-AM, Aldehydes, Bioactive Small Molecules, Building Blocks, C13-C60, Carbonyl Compounds, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Corticosteroid, Cytokines, Growth Factors and Hormones, H
  • {SNA} A-AM, Aldehydes, Bioactive Small Molecule Alphabetical Index, Building Blocks, C13-C60, Carbonyl Compounds, Chemical Synthesis, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Organic Building Blocks, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学,

相关文献及参考

  • [2]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598.
  • [3]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73.
  • [4]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104.
  • [5]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.
  • Beil. 8 ,IV,3491
  • Merck 14 ,225
  • [1]. Nanba K, et al. Aging and Adrenal Aldoste
  • [1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223.

安全信息

WGK Germany3
RTECSTU4523000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
Storage condition 2-8°C 
TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 23 mg/kg
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 141,14,1972

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 70 nmol/L
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 1,363,1970

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 23 mg/kg
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 141,14,1972

其他信息

  • Sigma Aldrich:52-39-1(sigmaaldrich)
  • 灭火剂:泡沫,沙土,二氧化碳,干粉, 雾状水
  • MOL 文件:52-39-1.mol
  • 储运特性:库房通风低温干燥; 与食品添加剂分开存放
  • Acros Organics:醛固酮 Aldosterone, 98%(52-39-1)
  • F:22-24-25
  • 用途一:诱导尿排泄钾离子K+，同时使肾脏吸收钠离子Na+。
  • 醛固酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 66000780 醛固酮(+4℃) 10mg 166.1元 2010/06/21 215360050 醛固酮 Aldosterone 98% 5 MG 829元 2010/06/21 215360250 醛固酮 Aldosterone 98% 25 MG 2868元
  • 外观性质:醛甾酮属一种类固醇(steroid)激素，为人体盐水平衡调节剂(一种矿物类皮质激素，主要由肾上腺皮质球状带分泌。此外，心脏、脑、血管壁也能合成和分泌醛甾酮。微溶于水，溶于乙醇、醚和氯仿。[a]20/D:155° (c=0.1, CHCl3)
  • 可燃性危险特性:易燃; 燃烧排放刺激烟雾
  • 类别:有毒物品

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Alcohols - Oxygen Compounds
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Corticosteroid - Steroid Hormones
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Aldosterone
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Cytokines, Growth Factors and Hormones
  5. Hormones
  6. Steroid Hormones
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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