Chlorhexidine 氯己定

CAS 55-56-1 MFCD00009673

化学结构图

55-56-1
SMILES: N=C(NC(=N)NCCCCCCNC(=N)NC(=N)NC1C=CC(Cl)=CC=1)NC1C=CC(Cl)=CC=1

化学属性

Mol. FormulaC22Cl2H30N10
Mol. Weight505
Melting Point134-136
Solubility0.08 G/100 ML (20 ºC)

别名和识别编码

Chemical NameChlorhexidine
Synonym 1,1'-HEXAMETHYLENEBIS[5-(4-CHLOROPHENYL)BIGUANIDE] 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) 1,1'-己基双[5-(对氯苯基)双胍] 1,1-Hexamethylenebis[5-(4-chlorophenyl)biguanide] 1,1’-hexamethylenebis(5-(p-chlorophenyl)-biguanid 1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide] 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane 1,6-Bis(p-chlorophenyldiguanido)hexane 1,6-DI(N-P-CHLOROPHENYL-DIGUANIDO) HEXANE 1,6-Di(4'-chlorophenyldiguanido)hexane 1,6-bis(5-(p-chlorophenyl)biguandino)hexane 1,6-bis(p-chlorophenyldiguanido)hexane 1,6-di(4’-chlorophenyldiguanido)hexane 2,4,11,13-Tetraazatetradecanediimidamide, 2,4,11,13-tetraazatetradecanediimidamide,n,n’’-bis(4-chlorophenyl)-3,12-diim Bis(5-(p-chlorophenyl)biguanidinio)hexane; Hexamethylenebis(5-(4-chlorophenyl)biguanide); N,N'-Bis(4-chlor
MDL NumberMFCD00009673
CAS Number55-56-1
PubChem Substance ID24857031
EC Number200-238-7
Beilstein Registry Number2826432
Chemical Name Translation氯己定
Merck Number13,2108
Wiswesser Line NotationGR DMYUM&MYUM&M6MYUM&MYUM&MR DG
LabNetwork Molecule IDLN00221195
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分类

  • {SA} Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds,
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Analytical Standards, Chlorhexidine, Chromatography, EP Standards,
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Analytical Standards, Analytical/Chromatography, Chlorhexidine, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards
  • Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks
  • {SNA} Analytical Standards

相关文献及参考

  • Merck:13,2108
  • Merck:13,2108 Beilstein: 12,IV,1201

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes 9
RTECSDU1925000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P305+P351+P338
  • P342+P311
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R50/53
  • R51/53
UN Number 3077 UN 3077 9/PG 3
Packing GroupIII
Hazard Class9
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9200 uL/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 6,2599,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VTYMAC VM/SAC, Veterinary Medicine and Small Animal Clinician. (Veterinary
   Medicine Publishing Co., 690 S. 4th St., POB 13265, Edwardsville, KS 66113)
   V.59-    1964-  Volume(issue)/page/year: 72,1330,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 632 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JCPEDZ Journal of Clinical Periodontology. (Munksgaard International
   Publishers, POB 2148, DK-1016 Copenhagen K, Denmark)  V.1-   1974-
   Volume(issue)/page/year: 4(5),66,1977

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >8 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VTYMAC VM/SAC, Veterinary Medicine and Small Animal Clinician. (Veterinary
   Medicine Publishing Co., 690 S. 4th St., POB 13265, Edwardsville, KS 66113)
   V.59-    1964-  Volume(is

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 7 umol/disc
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   28,249,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 14300 pmol/plate
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   28,249,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1680 mg/kg
SEX/DURATION            : female 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   MEXPAG Medicina Experimentalis.  (Basel, Switzerland)  V.1-11, 1959-64;
   V.18-19, 1968-69.  For publisher information, see JNMDBO.
   Volume(issue)/page/year: 10,361,1964

其他信息

  • 储运特性:库房通风低温干燥
  • Sigma Aldrich:55-56-1(sigmaaldrich)
  • 急性毒性:口服-大鼠 LD50: 9200 毫克/公斤;口服-小鼠 LDL0: 2515 毫克/公斤
  • 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物,氯化物烟雾
  • 毒性分级:中毒
  • MOL 文件:55-56-1.mol
  • 刺激数据:皮肤-人1.5 毫克/72小时 轻度
  • F:10-34
  • 用途一:为表面活性剂型杀菌剂,具有相当强的广谱抑菌、杀菌作用,对革兰阳性菌及阴性菌均有效
  • MSDS 信息:Hexamethylenebis(5-(4-chlorophenyl)biguanide)(55-56-1).msds
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品

系列性分类


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