Cysteamine 巯基乙胺

CAS 60-23-1 MFCD00008196

化学结构图

60-23-1
SMILES: NCCS

化学属性

Mol. FormulaC2H7NS
Mol. Weight77.15 g/mol
Density1.422
Melting Point94.0 to 99.0 deg-C
Stability易吸潮,二氧化碳敏感
Solubility易溶于水，易溶于醇。

别名和识别编码

Chemical NameCysteamine
Synonym 2-Aminoethanethiol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00008196
CAS Number60-23-1
PubChem Substance ID87562212
Beilstein Registry Number635649
EC Number200-463-0
Reaxys-RN635649
Merck Number2779
Chemical Name Translation巯基乙胺
Wiswesser Line NotationZ2SH
LabNetwork Molecule IDLN00193207
InChIInChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2
Canonical SMILESNCCS
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {uni_hamburg} no charge; thiol; 1fragment
  • {SNA} Amino Acid Library, Building Blocks, Cell Biology, Chemical Synthesis, Metabolic Libraries, Metabolomics, Organic Building Blocks, Sulfur Compounds,
  • {SNA} Amino Acid Librar
  • {SNA} Amino Acid Library, Building Blocks, Chemical Synthesis, Metabolic Libraries, Metabolomics, Organic Building Blocks, Sulfur Compounds, Thiols/Mercaptans
  • {SNA} Amino Acid Library Collection, Building Blocks, Chemical Synthesis, Metabolite Libraries and Collections, Organic Building Blocks, Sulfur Compounds, Thiols/Mercaptans, 代谢组学, 细胞生物学

产品应用

  • 具有解除金属对体内酶系统的损伤作用和具有抗氧化性质，可防止X线和放射性物质的损害。医药、农药、化妆品的中间体。

相关文献及参考

  • [2]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.
  • Merck: 14,2779
  • Merck: 14,2779 Beilstein: 4,IV,1570
  • Short: II/19b
  • Short: II/19c
  • [1]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.
  • [1]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.
  • [2]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P302+P352+P332+P313+P362+P364
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P332+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P405 Store locked up. 上锁保管。
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P308+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSKJ0175000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word
Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
UN Number 3335 3259
Storage condition 0-10 0-10°C 2-8°C 2-8°C, stored under nitrogen 储存温度 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Skin and Appendages - hair
REFERENCE :
   OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi.  Journal of the Osaka City
   Medical Center.  (Osaka, Japan)  V.4-23, 1955-74.  For publisher
   information, see OIGZDE.  Volume(issue)/page/year: 5,128,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 232 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Skin and Appendages - hair
REFERENCE :
   OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi.  Journal of the Osaka City
   Medical Center.  (Osaka, Japan)  V.4-23, 1955-74.  For publisher
   information, see OIGZDE.  Volume(issue)/page/year: 5,128,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulend

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 mg/L
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 12,234,1964

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 68,351,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,199,1978

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,199,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 42 gm/kg
SEX/DURATION            : female 70 day(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,523,1967

其他信息

  • 外观性质:白色结晶, 有不适气味。
  • 图谱信息:巯基乙胺(60-23-1)质谱(MS) 巯基乙胺(60-23-1)核磁图( 1 HNMR) 巯基乙胺(60-23-1)红外图谱(IR1) 巯基乙胺(60-23-1)红外图谱(IR2)
  • 储运特性:库房通风低温干燥
  • 用途一:医药、农药、化妆品的中间体。
  • 毒性分级:中毒
  • MOL 文件:60-23-1.mol
  • 巯基乙胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 TA064802 2-氨基乙硫醇 25g 698元 2011/08/23 62006980 半胱胺;巯乙胺; 2-巯基乙胺; 硫代乙醇胺; 2-氨基乙硫醇 5g 660元 2011/04/16 A0648 2-氨基乙硫醇 2-Aminoethanethiol 500G 5130元
  • 上游原料:氢硫酸 --> 氮丙啶
  • 易溶于水及醇，呈碱性反应，在空气中易氧化成为二硫化物。游离碱极不稳定，一般制成盐酸盐[156-57-0]。
  • TCI Shanghai:2-氨基乙硫醇 2-Aminoethanethiol,>;95.0%(T)(60-23-1)
  • F:1-3-10-13-34
  • MSDS 信息:巯乙胺(60-23-1).msds
  • 下游产品:噻唑磷 --> 辅酶 A --> (3-((6-氯-3-吡啶基)甲基)-1,3-噻唑啉-2-亚基)氰胺
  • Sigma Aldrich:60-23-1(sigmaaldrich)
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 用途二:具有解除金属对体内酶系统的损伤作用和具有抗氧化性质，可防止X线和放射性物质的损害。医药、农药、化妆品的中间体。
  • 方法一:由乙醇胺与溴化氢加成得β-溴化乙胺，再于硫酸存在下与二硫化碳环合，最后水解而得。此法反应容易控制，对设备要求不高，适于工业采用。另外，由环乙胺与硫化氢加成，亦可制得。
  • 急性毒性:腹腔-大鼠LD50: 232 毫克/公斤; 口服-小鼠LD50: 625 毫克/公斤
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
  • 类别:有毒物品

系列性分类

  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Amino Acid Library - Metabolic Libraries
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Amino Acid Library - Metabolic Libraries
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Thiols/Mercaptans - Sulfur Compounds
  1. Life Science 生命科学
  2. Antioxidants
  1. Functional Group 官能团索引
  2. alkylthiol
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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