Phloretin 根皮素

CAS 60-82-2 MFCD00002288

化学结构图

60-82-2
SMILES: O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O

化学属性

Mol. FormulaC15H14O5
Mol. Weight274
Melting Point260-262
Density1.422
TSCANo
SolubilitySoluble in ethanol, methanol, acetone, hot glacial acetic acid, alkalies, benzene (sparingly soluble), chloroform (sparingly soluble), and DMSO. Insoluble in water, and ether.
Refractive index1.573-1.575
Stability对热和光线敏感

别名和识别编码

Chemical NamePhloretin
CAS Number60-82-2
Alfabeta NameTRIHYDROXYHYDROXYPHENYLPROPIOPHENONE 24634()-----,,'''
MDL NumberMFCD00002288
Synonym 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, 2μ,4μ,6μ-Trihydroxy-3-(4-hydroxyphenyl)propiophenone 4,2',4',6'-TETRAHYDROXYDIHYDROCHALCONE 2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)-PROPIOPHENONE β-(4-hydroxyphenyl)-2,4,6-trihydroxypropiophenone Phloretin,98% 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone PHLORETIN (NATURAL)
EC Number200-488-7
Beilstein Registry Number1887240
Merck Number7326
PubChem Substance ID4788
Chemical Name Translation根皮素
Reaxys-RN1887240
InChIInChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
LabNetwork Molecule IDLN00116889
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分类

  • {SNA} Calcium Channel Modulators, Inhibitors and Activators, Ion Channels, Voltage-gated Ion Channels, 细胞信号转导和神经科学, 细胞生物学
  • Inhibitors
  • {SNA} Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Inhibitors and Activators, Ion Channels, P, Voltage-gated Ion Channels
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Aromatics
  • Protein Kinase Inhibitors and Activators

产品应用

  • A calcium channel protein inhibitor.

相关文献及参考

  • [2]. Luo H, et al. Phloretin induces apoptosis of BEL-7402 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28(7):1249-51.
  • [3]. Huang WC, et al. Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures.Mol Nutr Food Res. 2013 Oct;57(10):1803-13.
  • [4]. Wang SP, et al. Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis.Evid Based Complement Alternat Med. 2016;2016:9831263.
  • ########
  • [1]. Kasahara T, Kasahara M. Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae. Biochem J. 1996 Apr 1;315 ( Pt 1):177-82.
  • [1]. Kasahara T, Kasahara M. Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae. Biochem J. 1996 Apr 1;315 ( Pt 1):177-82.
  • [2]. Luo H, et al. Phloretin induces apoptosis of BEL-7402 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28(7):1249-51.

安全信息

Warnings IRRITANT
Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P352+P332+P313+P362+P364
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Storage condition 0-10 0-10°C 储存温度-20°C 储存温度 2-8°C 2-8°C
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

其他信息

  • Alfa Aesar:根皮素,98% Phloretin, 98%(60-82-2)
  • MOL 文件:60-82-2.mol
  • F:3-10
  • 根皮素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 307655000 根皮素 Phloretin 98% 500 MG 3054元 2010/06/21 307651000 根皮素 Phloretin 98% 100 MG 843元 2010/05/25 L10991 根皮素, 98% Phloretin, 98% 25mg 246元
  • 存储注意事项:光敏感;氮气保护
  • 用途一:用作药品，化妆品助剂，食品添加剂等
  • 检测方法:HPLC
  • Phloretin 是一种二氢查尔酮，含有多元酚。
  • Acros Organics:根皮素 Phloretin, 98%(60-82-2)
  • Sigma Aldrich:60-82-2(sigmaaldrich)
  • Phloretin

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones - Carbonyl Compounds
  6. C15 to C38 - Ketones
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones - Carbonyl Compounds
  6. C15 to C38 - Ketones
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Calcium Channel Modulators - Voltage-gated Ion Channels
  7. Inhibitors and Activators - Calcium Channel Modulators
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aromatic Ketones
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones 酮
  6. C13 to C14
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Protein Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Ion Channels
  5. Voltage-gated Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Neuroscience
  5. Ion Channels
  6. Ligand-Gated Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Immune System Proteins
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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