N,N-Dimethyl-2-chloropropylamine hydrochloride N,N-二甲氨基-2-氯丙烷盐酸盐

CAS 4584-49-0 MFCD00012534

化学结构图

4584-49-0
SMILES: CC(Cl)CN(C)C.Cl

化学属性

Mol. FormulaC5H13Cl2N
Mol. Weight158.07
Melting Point187-190 °C
TSCAYes
Solubility2000 G/L (20 º C)
Appearance 该品为白色结晶固体。熔点 191-195℃，水溶性 2000g/L (20℃) 无色结晶。

别名和识别编码

Chemical Name2-Dimethylaminoisopropyl Chloride Hydrochloride
MDL NumberMFCD00012534
CAS Number4584-49-0
Synonym 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {} {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {} {} {} {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloro-N,N-dimethylpropan-1-amine hydr
PubChem Substance ID94294
EC Number224-971-7
Beilstein Registry Number3670215
Chemical Name TranslationN,N-二甲氨基-2-氯丙烷盐酸盐
Reaxys-RN3670215
InChIKeyOCWGRWAYARCRTQ-UHFFFAOYSA-N
Wiswesser Line NotationGY1&1N1&1 &GH
LabNetwork Molecule IDLN01288683
InChIInChI=1S/C5H12ClN.ClH/c1-5(6)4-7(2)3;/h5H,4H2,1-3H3;1H
Canonical SMILESCC(Cl)CN(C)C.[H]Cl
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分类

  • {SNA} Amine Salts, Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSTY1225000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312
  • P301+P316
  • P301+P317
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Codes Xn Xn,Xi Xi
Packing GroupIII
Hazard Class6.1(b)
UN Number 2811 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 98,121,1950

其他信息

  • Acros Organics:3-二甲氨基丙基氯盐酸盐 3-Dimethylaminopropylchloride hydrochloride, 99%(5407-04-5)
  • 用途一:用于医药工业
  • N,N-二甲氨基氯丙烷盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D0663 3-二甲氨基氯丙烷盐酸盐 3-(Dimethylamino)propyl Chloride Hydrochloride 500G 1030元 2014/06/02 D0663 3-二甲氨基氯丙烷盐酸盐 3-(Dimethylamino)propyl Chloride Hydrochloride 25G 234元 2010/06/21 115911000 N,N-二甲氨基氯丙烷盐酸盐 3-Dimethylaminopropylchloride hydrochloride 99% 100 GR 435元
  • Hazard Note:Irritant
  • 用途二:药物炎痛静、泰尔登、氯丙嗪、丙咪嗪、多虑平、阿米替林等的中间体。
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • 方法一:由1-二甲氨基-2-丙醇用氯化亚砜氯化而得。
  • 海关编码:29211980
  • MOL 文件:4584-49-0.mol
  • 用途一:用于合成氯丙嗪、盐酸多虑平、泰尔登等药物
  • 方法一:将二甲胺和丙烯醇送入反应罐，在氢氧化钠存在下，在130-150℃温度和127.5-147.1kPa压力下加压合成，经回流14h制得1-二甲氨基丙-3-醇，再用亚硫酰氯进行氯化，在55-90℃温度下反应9-10h即得1-二甲氨基-3-氯丙烷盐酸盐成品。
  • 下游产品:三甲基-1,3-丙二胺 --> 1-(3-二甲氨基丙基)哌嗪
  • F:3
  • 图谱信息:N,N-二甲氨基-2-氯丙烷盐酸盐(4584-49-0)质谱(MS) N,N-二甲氨基-2-氯丙烷盐酸盐(4584-49-0)红外图谱(IR1) N,N-二甲氨基-2-氯丙烷盐酸盐(4584-49-0)红外图谱(IR2)
  • 储运特性:库房低温通风干燥; 与食品原料分开存放
  • TCI Sh
  • 敏感性:Hygroscopic
  • 可燃性危险特性:可燃； 火场释放氮氧化物， 氯化物气体
  • TCI Shanghai:N,N-二甲氨基-2-氯丙烷盐酸盐 2-Chloro-1-(dimethylamino)propane Hydrochloride,>;98.0%(T)(4584-49-0)
  • MOL 文件:5407-04-5.mol
  • 用途二:中枢抑制药美散痛、抗组织胺药非那根的中间体。
  • 类别:有毒物质
  • Acros Organics:2-二甲氨基异丙基氯盐酸盐 2-Dimethylaminoisoprop
  • N,N-二甲氨基-2-氯丙烷盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1665 2-氯-1-(二甲氨基)丙烷盐酸盐 2-Chloro-1-(dimethylamino
  • Sigma Aldrich:4584-49-0(sigmaaldrich)
  • MSDS 信息:2-Dimethylaminoisopropyl chloride hydrochloride(4584-49-0).msds
  • 急性毒性:口服- 大鼠 LD50: 417 毫克/ 公斤
  • 毒性分级:高毒
  • Alfa Aesar:2-二甲基氨异丙基氯盐酸盐,98% 2-Dimethylaminoisopropyl chloride hydrochloride, 98%(4584-49-0)
  • 上游原料:氧氯化硫 --> 二甲胺 --> 丙烯醇

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amine Salts - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amine Salts - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amidates/Imidates

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