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• 试剂商城
• 直接询价

分类

• Alphabetical, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
• {SA} Alphabetical, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Fluorescent Indicators and Probes, Fluorescent Probes, Labels, Particles and Stains, Lipophilic and Membrane Probes, Lipophilic and Membrane Probes for Flow Cytometry,

产品应用

• Useful as a laser dye and to have selective cell growth effects. Mitochondrial specific fluorescent dye and substrate for P-glycoprotein.

相关文献及参考

• 1. L. Benel et al. Bas. Appl. Histochem. 33 , 71, (1989)
• Wuchter, C., et al. Haematologica 85 , 711-721, (2000) 摘要
• Minderman, H., et al., DiOC2(3) is not a substrate for multidrug resistance protein (MRP)-mediated drug efflux. Cytometry 25 , 14-20, (1996)
• Merck 14 ,10356

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 60 mg/kg
SEX/DURATION            : female 7-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   9,29,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 60 mg/kg
SEX/DURATION            : female 7-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 40,143,1989

其他信息

• Rhodamine 123 is a cationic dye that emits a green fluorescence. Research observations indicate that Rhodamine 123 can be used to probe the electrochemical gradient in mitochondria, in flow cytometry to detect the activity of P-glycoprotein efflux, and as a compound for P-GP mediating transport. Studies report that Rhodamine 123 can decrease the clonal growth of carcinoma cells in vitro, and that it can associate with placental P-gp. Rhodamine 123 is a substrate of Mdr (P-glycoprotein). Rhodamine 123 is a substrate of MRP1.