2-Amino-1,9-dihydro-6H-purine-6-thione 6-硫鸟嘌呤

CAS 154-42-7 MFCD00127785

化学结构图

154-42-7
SMILES: Nc1nc2[nH]cnc2c(=S)[nH]1

化学属性

Mol. FormulaC5H5N5S
Mol. Weight167.19
Appearance Solid powder
SolubilitySoluble in DMSO, not in water
Melting Point≥300 °C
Boiling Point555.4 °C at 760 mmHg

别名和识别编码

Chemical Name2-Amino-1,9-dihydro-6H-purine-6-thione
Chemical Name Translation6-硫鸟嘌呤
PubChem Substance ID2723601
InChIInChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
FormulaC5H5N5S
Synonym 6-Thioguanine {LY} 6-Thioguanine {} {LY} 6-Thioguanine {} {} {LY} 6-Thioguanine {} {} {} {LY} 6-Thioguanine {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thioguanine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-
IUPAC Name2-amino-1H-purine-6(7H)-thione
InChIKeyWYWHKKSPHMUBEB-UHFFFAOYSA-N
Canonical SMILESSC1=NC(N)=NC2=C1N=CN2
MDL NumberMFCD02730136
CAS Number154-42-7
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产品应用

  • Tioguanine (INN, BAN), or thioguanine (AAN, USAN), commonly referred to as 6-thioguanine (6-TG) is a medication used to treat a number of types of leukemia. It has been used less frequently in recent years because of safety concerns. However, it is becoming more widely used for treating ulcerative colitis and some autoimmune diseases.

相关文献及参考

  • [2]. Wang H, et al. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry. 2009 Mar 17;48(10):2290-9.
  • [3]. LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76(7):649-55.
  • [1]. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102.
  • [1]. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102.
  • [2]. Wang H, et al. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry. 2009 Mar 17;48(10):2290-9.
  • [3]. LaDuke KE, et al. Effects of azathioprine, 6-m

安全信息

Storage condition 2-8°C {LY} 2-8°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C

系列性分类


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