N1-Benzyl-N2,N2-Dimethyl-N1-(Pyridin-2-Yl)Ethane-1,2-Diamine Hydrochloride N1-苄基-N2,N2-二甲基-N1-(吡啶-2-基)乙烷-1,2-二胺盐酸盐
CAS 154-69-8 MFCD00012815
化学结构图
SMILES: CN(C)CCN(Cc1ccccc1)c1ccccn1.Cl
化学属性
| Mol. Formula | C16H22ClN3 |
|---|---|
| Mol. Weight | 292 |
| Melting Point | 192-193 ºC |
| Density | 1.20 |
别名和识别编码
| Chemical Name | N1-Benzyl-N2,N2-Dimethyl-N1-(Pyridin-2-Yl)Ethane-1,2-Diamine Hydrochloride |
|---|---|
| CAS Number | 154-69-8 |
| Synonym | N-Benzyl-N',N'-dimethyl-N-2-pyridyl-ethylenediamine hydrochloride N,N-dimethyl-N'-(phenylmethyl)-N'-pyridinyl-1,2-ethanediamine hydrochloride 2-(Benzyl(2-(dimethylamino)ethyl)amino)pyridine hydrochloride 2-(Benzyl(2-(dimethylamino)ethyl)amino)pyridine monohydrochloride N-Benzyl-N-dimethylaminoethyl alpha-aminopyridine hydrochloride N-Benzyl-N-alpha-pyridyl-N',N'-dimethyl-aethylendiamin-hydrochlorid 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, ######## 2-(苄基[2-二甲基氨乙基]氨基)吡啶 N-苄基-N′,N′-二甲基-N-(2-吡啶基)乙二胺 盐酸盐 Pyrinamine; ReCovr; Stanzamine; N1,N1-Dimethyl-N2-(phenylmethyl)-N2-(2-pyridinyl)-1,2-ethanediamine hydrochloride tripelennamine hydrochloride 苄吡二胺 盐酸盐 |
| MDL Number | MFCD00012815 |
| EC Number | 205-833-5 |
| PubChem Substance ID | 9066 |
| Chemical Name Translation | N1-苄基-N2,N2-二甲基-N1-(吡啶-2-基)乙烷-1,2-二胺盐酸盐 |
| Wiswesser Line Notation | T6NJ BN1R&2N1&1 &GH |
| LabNetwork Molecule ID | LN00337400 |
| InChI | InChI=1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H |
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分类
- {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; 6RingOnly; 6ring; 2fragments; ionic
- Heterocycles
- Pharmaceuticals
- Amines
- Intermediates & Fine Chemicals
- Aromatics
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Synthesis, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, Organic Bases, Synthetic Reagents, T, TP - TZ
- {SNA} Acids & Bases, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bases, Chemical Synthesis, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds,
产品应用
- Tripelennamine is a first-generation antihistamine, used in the treatment of asthma, hay fever, and urticaria.
相关文献及参考
- [2]. Wasfi IA, Abdel Hadi AA, Elghazali M, Comparative disposition of tripelennamine in horses and camels after intravenous administration. J Vet Pharmacol Ther. 2000 Jun;23(3):145-52.
- [3]. Yeh SY, Todd GD, Johnson RE, The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39(6):669-76.
- He, N., et al.: Eur. J. Clin. Pharmacol., 57, 847 (2002),
- Serafimova, R., et al.: Chemi. Res. Toxicol., 20, 1225 (2007),
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
- Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea REFERENCE : JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX. Volume(issue)/page/year: 81,55,1947
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 41 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,72,1955
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 97 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(is
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/yea
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 100 umol/L REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
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