Boldine 波尔定碱

CAS 476-70-0 MFCD00135040

化学结构图

476-70-0
SMILES: COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C

化学属性

Mol. FormulaC19H21NO4
Mol. Weight327.41
Melting Point162-164 ºC

别名和识别编码

Chemical NameBoldine
MDL NumberMFCD00135040
CAS Number476-70-0
Synonym (+)-(S)-Boldine (+)-(s)-boldine (+)-BOLDINE (+)-Boldine (-)-6-Methyl-1,10-dimethoxy-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol (6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol (S)-Boldine (s)-boldine (s)-yl 1,10-DIMETHOXY-2,9-DIHYDROXYAPORPHINE 1,10-dimethoxy-6a-alpha-aporphine-2,9-diol 1,10-dimethoxy-6a-alpha-aporphine-9-diol 2 6-DIHYDROXY-3 5-DIMETHOXYAPORPHIN 2,9-DIHYDROXY-1,10-DIMETHOXYAPORPHINE 2,9-Dihydroxy-1,10-dimethoxyaporphine 2,9-Dihydroxy-1,10-dimethoxyaporphine, Boldine 2,9-二羟基-1,10-二甲氧基阿朴啡 4H-Dibenzo(de,g)quinoline-2,9-diol, 4h-dibenzo(de,g)quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-meth 4h-dibenzo[de,g]quinoline-2,9
Beilstein Registry Number0094036
EC Number207-509-9
PubChem Substance ID10154
Chemical Name Translation波尔定碱
Merck Number13,1316
Wiswesser Line NotationT C6666 1A Q KN&TT&J EO1 FQ K1 PQ QO1
InChIInChI=1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BI - BZ, Biochemicals and Reagents, Chromatography, Drugs & Metabolites, Enzyme Inhibitors, Enzymes, Inhibitors, and Substrates, Forensic and Veterinary Standards, Neat Compounds, Protease Inhibitor Specificity Index, Protease Inhibitors, Trypsin
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BI - BZ, Biochemicals and Reagents, Chromatography, Drugs & Metabolites, Enzyme Inhibitors, Fo

安全信息

GHS Symbol
RTECSCE0750000
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Packing GroupIII
Safety Statements
  • S1 Keep locked up 上锁；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Hazard Class6.1(b)
UN Number 1544 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4185119

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 38,537,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 38,537,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,145,1991

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,145,1991

Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P317
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • Sigma Aldrich:476-70-0(sigmaaldrich)
  • MOL 文件:476-70-0.mol

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs & Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BI - BZ - B
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BI - BZ - B
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Protease Inhibitors - Enzyme Inhibitors
  6. Protease Inhibitor Specificity Index - Protease Inhibitors
  7. Trypsin - Protease Inhibitor Specificity Index

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