Triammonium 3,3'-[(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis[6-hydroxybenzoic acid] 铝试剂

CAS 569-58-4 MFCD00040925

化学结构图

569-58-4
SMILES: N.N.N.O=C(O)C1=CC(=C(c2ccc(O)c(C(=O)O)c2)c2ccc(O)c(C(=O)O)c2)C=CC1=O

化学属性

Mol. FormulaC22H23N3O9
Mol. Weight473
Melting Point220-225
TSCAYes
Density0.806
Solubility800 G/L (20 ºC)
Stability对湿度敏感
Appearance powder

别名和识别编码

Chemical NameTriammonium 3,3'-[(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis[6-hydroxybenzoic acid]
Synonym 5-[(3-羧基-4-羟基苯基)(3-羧基-4-氧代-2,5-环己二烯-1-亚基)甲基]-2-羟基苯甲酸三铵盐 ALUMINONE AMMONIUM AURINTRICARBOXYLATE Aluminon Aluminon, Ammonium aurintricarboxylate Ammonium aurintricarboxylate Ammonium auritricarboxylate Aurine-tricarboxylate d'ammonium Benzoicacid,5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy-,triammoniumsalt C.I. 43810; Aurintricarboxylic acid triammonium salt; Triammonium 5,5'-(3-carboxylato-4-oxocyclohexa-2,5-dienylidenemethylene)disalicylate C.I. Mordant Violet 39, triammonium salt Triammonium aurintricarboxylate lysofon 水杨酰邻氨基酚 玫瑰红三羧酸铵 玫红三羧酸铵 铝试剂 铝试剂,ACS
CAS Number569-58-4
PubChem Substance ID13710524
EC Number209-319-1
Beilstein Registry Number3900820
MDL NumberMFCD00040925
Reaxys-RN3900820
Merck Number322
Chemical Name Translation铝试剂
Wiswesser Line NotationL6V DHJ BVQ DYR DQ CVQ&R DQ CVQ &ZH 3
LabNetwork Molecule IDLN04682658
InChIInChI=1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31);3*1H3
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分类

  • {SNA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, R to Z, Topoisomerase II
  • {SNA} Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, R to Z, Topoisomerase II, 生化试剂, 酶、抑制剂和底物
  • {SNA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, R to Z, Topoisomerase II, 酶、抑制剂和底物
  • {SA} Biochemicals and Reagents, Building Blocks, Carbonyl Compounds, Carboxylic Acid Salts, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,

产品应用

  • 络合滴定指示剂,测定水,食物及组织中的铝,包括软水,焙粉,媒染剂,浆纸,鞣革,制造颜料,镀铜,澄清剂等,色层分析用试剂。

相关文献及参考

  • Benchokroun, Y., et al., Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells. Biochem. Pharmacol. 49 , 305-313, (1995) 摘要
  • Okada, N., and Koizumi, S., A neuroprotective compound, aurintricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells. J. Biol. Chem. 270 , 16464, (1995) 摘要
  • Aronica, E.M., et al., Aurintricarboxylic acid prevents GLUR2 mRNA down-regulation and delayed neurodegeneration in hippocampal CA neurons of gerbil after global ischemia. Proc. Natl. Acad. Sci. U. S. A. 95 , 7115-7120, (1998)
  • Okada, N., and Koizumi, S., Tyrosine phosphorylation of ErbB4 is stimulated by aurintricarboxylic acid in human neuroblastoma SH-SY5Y cells. Biochem. Biophys. Res. Commun. 230 , 266-269, (1997) 摘要
  • Merck:14,322
  • Merck:14,322 Beilstein:10(2)775
  • Merck 14 ,322
  • Rui, H., et al., Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid. J. Biol. Chem. 273 , 28-32, (1998) 摘要

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
RTECSGU4800000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
Storage condition 密封保存。
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 32(3),48,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
   Blood - hemorrhage
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 19,169,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 340 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
   Blood - hemorrhage
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 19,169,1959

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 211 umol/kg
REFERENCE :
   VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.1-    1968-
   Volume(issue)/page/year: 23,137,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 mg/kg
SEX/DURATION            : male 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 156,1701,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 857 ug/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 156,1701,1962

其他信息

  • 稳定性:Stable.
  • 海关编码:29189090
  • EPA化学物质信息:Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)( 3-carboxy-4-oxo-2,5-cyclohexadien- 1-ylidene)methyl]-2-hydroxy-, triammonium salt(569-58-4)
  • 用途:用于铝、氮等化合物的比色测定和钍、镓 钪的显色反应等
  • MOL 文件:569-58-4.mol
  • RTECS号:GU4800000
  • 铝试剂价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30010860 玫瑰红三羧酸铵 25g 29元 2011/08/23 30010814 玫瑰红三羧酸铵 25g 35元 2011/08/23 30010824 玫瑰红三羧酸铵 25g 24元
  • 图谱信息:铝试剂(569-58-4)红外图谱(IR1) 铝试剂(569-58-4)红外图谱(IR2) 铝试剂(569-58-4)质谱(MS)
  • 易溶于水,微溶于乙醇,几乎不溶于乙醚、丙酮和氯仿。最大吸收波长522(450)nm。半数致死量(小鼠,静脉)4mg/kg。有刺激性。
  • 生产方法:于20ml浓硫酸中,分次加入10g(0.145mol)固体亚硝酸钠,同时控制加入速度,以便只放出少量的一氧化氮。当溶解完全后,边搅拌边分次加入20g(0.145mol)水杨酸,全部过程约15min。然后在20℃将此混合物搅拌至全部固体均溶解,此粘稠液呈亮红色至棕色。将液体入在冰浴 上,使温度降至0℃,边搅拌边慢慢滴加5ml(0.065mol)35-40%的甲醛溶液,反应温度不得超过5℃,反应完全后,加100g碎冰和500ml冰水,搅拌至形成固体小块为止。过滤,用冰水洗涤数次,抽干,再溶于1:2(体积比)氨水中,滤纸过滤。滤液在蒸汽浴上蒸干。约得19.22g棕黄色玻璃状固体物。产率83-86%。

系列性分类


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